ANTI-HYPERLIPIDEMIC DRUGS
DRUG PROPERTIES MOA ADVERSE TREATMENT/ INDICATIONS LIPO-
EFFECTS PREVENTION PROTIEN
TYPE
Evening or
HMG CoA RI Taken OD, low a) Inhibit HMG CoA Most: bedtime.
also known bioavailability, reductase → In GIT (cramps, 1)Atorva/Rosuva
statins 1ST pass ↓CHO→↓VLDL diarrhea, Statins ↓ 1. IIa
metabolism formation &↓LDL Constipation, withdraw; Long ½ life
(Atorvastatin, takes place. synthesis. Heartburn.) 2)Lova/Simva 2. IIb
Rosuvastatin, Fluid ↓
lovastatin, Metabolized by b)↑LDL receptor→ Less: administration Cross BBB, sleep 3. III
simvastatin, CYTP450 (CYP3A ↓serum LDL, ↓ TG & ↑hepatic for renal disorder.
Fluvastatin, & CYP2C) ↑HDL enzyme level, function 3)Fluvastatin
pravastatin) Rhabdomyolysis ↓
(Myalgia→ Less myopathy.
Myositis→ Combined with
Myoglobinuria) Niacin.
Homozygous
After absorption covert
familial hyper
to→ Ez.glucrunide→
CHO
enter circulation
Inhibit → in intestine→ localize Well tolerated 1. IIa
½ life of 22 hrs
absorption of in brush border &
EZETIMIBE dietary CHO inhibit absorption of Some complain 2. IIb
Fix dose
biliary & dietary CHO→ of headache &
Eliminated in by disruption of myalgia 3. III
↓LDL 19-20%
feces Annexin-2 & Caveolin-1
Ezetimibe+ Statin
↓LDL same as
statin highest
dose.
DRUG PROPERTIES MOA ADVERSE TREATMENT/ INDICATIONS LIPO-
EFFECTS PREVENTION PROTIEN
TYPE
Evening or
HMG CoA RI Taken OD, low a) Inhibit HMG CoA Most: bedtime.
also known bioavailability, reductase → In GIT (cramps, 1)Atorva/Rosuva
statins 1ST pass ↓CHO→↓VLDL diarrhea, Statins ↓ 1. IIa
metabolism formation &↓LDL Constipation, withdraw; Long ½ life
(Atorvastatin, takes place. synthesis. Heartburn.) 2)Lova/Simva 2. IIb
Rosuvastatin, Fluid ↓
lovastatin, Metabolized by b)↑LDL receptor→ Less: administration Cross BBB, sleep 3. III
simvastatin, CYTP450 (CYP3A ↓serum LDL, ↓ TG & ↑hepatic for renal disorder.
Fluvastatin, & CYP2C) ↑HDL enzyme level, function 3)Fluvastatin
pravastatin) Rhabdomyolysis ↓
(Myalgia→ Less myopathy.
Myositis→ Combined with
Myoglobinuria) Niacin.
Homozygous
After absorption covert
familial hyper
to→ Ez.glucrunide→
CHO
enter circulation
Inhibit → in intestine→ localize Well tolerated 1. IIa
½ life of 22 hrs
absorption of in brush border &
EZETIMIBE dietary CHO inhibit absorption of Some complain 2. IIb
Fix dose
biliary & dietary CHO→ of headache &
Eliminated in by disruption of myalgia 3. III
↓LDL 19-20%
feces Annexin-2 & Caveolin-1
Ezetimibe+ Statin
↓LDL same as
statin highest
dose.
