Anti-Inflammatory, Antiarthritis, and Antigout Drugs
Assignment 5
1. Define the following terms:
a. Antigout Drug:
Is a uric acid synthesis inhibitor that prevents gout and shorten gout attacks.
Most common drugs used to reduce the uric acid levels associated with gout. For gout
prevention, they must be taken daily.
b. Anti-inflammatory Drug:
The primary purpose of these drugs is to reduce pain and prevent or limit the tissue and
blood vessels responses to injury or invasion.
c. Corticosteroids:
Also known as glucocorticoids, prevent or limit inflammation by slowing or stopping all
known pathways of inflammatory cytokine production. They are similar to the natural
cortisol hormones secreted by the adrenal gland that are necessary for life.
d. Disease-modifying Antirheumatic Drug (DMARD):
These drugs reduce the progression and tissue destruction of the inflammatory disease
process, especially rheumatoid arthritis by inhibiting TNF.
Inflammation Cause and Action
1. Describe inflammation:
Is a predictable set of tissue and blood vessel actions caused by WBCs; leukocytes and their
products as a response to injury or infection.
K Rowe LVN Page 1 of 14 Rev: Jan. 2019
, Anti-Inflammatory, Antiarthritis, and Antigout Drugs
Assignment 5
2. List the five major symptoms of inflammation:
a. Pain
b. Redness
c. Warmth
d. Swelling
e. Loss of function
3. What are the names of the mediators and what are they important in starting and continuing?
a. Kinins
b. Prostaglandin (PGs)
c. Histamine
d. Tumor necrosis factor (TNF)
4. Histamine act on blood vessels in the injured area causing them to do what?
Histamine causes the blood vessels to dilate and lose fluid from the capillaries. Results in redness
and warmth of the tissues.
5. What do release Kinins trigger?
Kinins trigger pain receptors in the nerve endings which make the area painful.
K Rowe LVN Page 2 of 14 Rev: Jan. 2019
Assignment 5
1. Define the following terms:
a. Antigout Drug:
Is a uric acid synthesis inhibitor that prevents gout and shorten gout attacks.
Most common drugs used to reduce the uric acid levels associated with gout. For gout
prevention, they must be taken daily.
b. Anti-inflammatory Drug:
The primary purpose of these drugs is to reduce pain and prevent or limit the tissue and
blood vessels responses to injury or invasion.
c. Corticosteroids:
Also known as glucocorticoids, prevent or limit inflammation by slowing or stopping all
known pathways of inflammatory cytokine production. They are similar to the natural
cortisol hormones secreted by the adrenal gland that are necessary for life.
d. Disease-modifying Antirheumatic Drug (DMARD):
These drugs reduce the progression and tissue destruction of the inflammatory disease
process, especially rheumatoid arthritis by inhibiting TNF.
Inflammation Cause and Action
1. Describe inflammation:
Is a predictable set of tissue and blood vessel actions caused by WBCs; leukocytes and their
products as a response to injury or infection.
K Rowe LVN Page 1 of 14 Rev: Jan. 2019
, Anti-Inflammatory, Antiarthritis, and Antigout Drugs
Assignment 5
2. List the five major symptoms of inflammation:
a. Pain
b. Redness
c. Warmth
d. Swelling
e. Loss of function
3. What are the names of the mediators and what are they important in starting and continuing?
a. Kinins
b. Prostaglandin (PGs)
c. Histamine
d. Tumor necrosis factor (TNF)
4. Histamine act on blood vessels in the injured area causing them to do what?
Histamine causes the blood vessels to dilate and lose fluid from the capillaries. Results in redness
and warmth of the tissues.
5. What do release Kinins trigger?
Kinins trigger pain receptors in the nerve endings which make the area painful.
K Rowe LVN Page 2 of 14 Rev: Jan. 2019
