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C785 Biochemistry Study Guide
Which mRNA sequence results in a polypeptide that contains three amino
acids?
5' - CUU GAU ACU UAG - 3'
Which RNA sequence would end in the following polypeptide?
Phe-Thr-Val-Stop
5' - UUC ACA GUA UAA - 3'
In which situation would altering a protein structure lead to a disease state?
A mutation in aconitase blocks an essential step in aerobic metabolism
BIOCHEMIST C785 Biochemistry Study Guide
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Reference the amino acid chart below to answer the question.
BIOCHEMIST C785 Biochemistry Study Guide
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,BIOCHEMIST C785 Biochemistry Study Guide
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How can an alteration in protein structure lead to a disease state?
A mutation replaces an isoleucine with an aspartic acid in a transcription factor protein,
which blocks the normal folding of the protein and its function in the expression of
certain genes.
Which structural level is impacted by denaturing a protein containing a single
polypeptide?
Tertiary
Frying an egg changes the egg white from a clear liquid to an opaque solid.
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Which molecular change in the albumin protein causes this change in
appearance?
Hydrophobic interactions form between denatured egg white proteins.
What is the driving mechanism of plaque formation in prion diseases?
Propagation of misfolding from one protein to another
Which feature of a protein made of a single polypeptide chain is most directly
responsible for its function?
Three-dimensional structure
How does the Bohr effect describe the relationship between carbon dioxide
levels, blood pH and the amount of oxygen bound to hemoglobin?
An increase in carbon dioxide production leads to a decrease in blood pH, causing
hemoglobin to release oxygen more readily.
Which statement describes the binding of oxygen gas to a heme group?
The binding of oxygen gas to heme changes the structure of the heme group.
Which characteristic of myoglobin makes it an effective oxygen storage
molecule?
It has a high affinity for oxygen.
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