OVERVIEW
This worksheet complements the Central Dogma and Genetic Medicine Click & Learn from HHMI
BioInteractive. This worksheet comes directly from HHMI BioInteractive.
PROCEDURE
As you proceed through the Click & Learn, follow the instructions below and answer the questions in the
spaces provided.
1. Let’s review! The central dogma of molecular biology refers to the process of gene expression. Write
the definition of gene expression in your own words.
A surfacing of a phenotype of a characteristic or effect assigned to a certain gene.
2. Click on the “Central Dogma” menu tab at the top of the screen.
The table below outlines the steps in eukaryotic gene expression. Click on each tab in the tutorial
and briefly summarize each step below. There are little arrows next to each molecule involved. Click
on these to get more information on each molecule.
Gene expression steps Molecules involved Summary
What molecules and proteins are What happens during this step?
involved in this step?
RNA Polymerase converts
Transcription RNA polymerase, DNA, RNA, information from a section of
Exon, and Intron. the DNA into a complementary
sequence with the tRNA.
The spliceosome cuts up
RNA Splicing Spliceosome, Inron, and Exon. introns and splices together
exons to create mRNA.
The mRNA is sent out the
mRNA Transport mRNA nucleus and into the
cytoplasm.
Amino acids are put together
Translation mRNA, tRNA, Ribosome, and in a chain by the ribosome
Polypeptide. once it reads the code from
the tRNA that it received from
the mRNA.
When the chain is complete
Protein Processing Polypeptide the polypeptide will fold into a
3D protein and do a specific
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, kind of function. This is done in
the golgi or in cytoplasm.
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