NSG124 Pharmacology Drug Card Template
Who takes this? How does it work? Pharmacokinetics/How is it given?
Hypertension, diabetic Blocks production of angiotensin II
nephropathy, heart failure,
MI
PO
Excreted in the urine
Peak 1 hr; duration 2-6 hr; half-life <2
hr, increased in renal disease
Contraindications Drug & Class How does the nurse know it is working?
Pregnancy and Breastfeeding, 1. Captopril [Capten] 9.1 + 9.4 + 9.5
children, potassium-sparing
diuretics Angiotensin-Converting Enzyme (ACE)
Inhibitor
Decrease in B/P, decreased diabetic
nephropathy symptoms, Improve
hemodynamics in patients with heart
failure
Nursing Considerations: Adverse Effects
What is the nurse going to do/teach/assess?
Should be administered 1 hour before meals or 2 hr after meals
Do not discontinue product abruptly – adhere to dosage schedule, even if
feeling better.
Warn patients about the possibility of persistent cough - avoid OTC
Hyperkalemia may occur – avoid potassium supplement and potassium-
containing salt substitutes
Signs and symptoms of
angioedema Signs and symptoms
of neutropenia
, Cough – persistent dry, irritating,
nonproductive, Neutropenia,
Angioedema
NSG124 Pharmacology Drug Card Template
Who takes this? How does it work? Pharmacokinetics/How is it given?
Patients with hypertension, Blocks the actions of angiotensin II
diabetic nephropathy,
Oral – may be taken with or without food
Peak 1 hr; half-life 2 hr;
, prevention, diabetic
retinopathy
Excreted in urine/feces
Contraindications Drug & Class How does the nurse know it is working?
Pregnancy-during the 2nd and 1. Losartan [Cozaar]9.1 + 9.4 + 9.5
3rd trimesters, Bilateral renal
artery stenosis, a history of Antihypertensive
hypersensitivity reactions Angiotensin II receptor antagonist
Decreased B/P
Decrease diabetic
nephropathy
Nursing Considerations: Adverse Effects
What is the nurse going to do/teach/assess?
Photosensitivity may occur- avoid sunlight, wear sunscreen if in sunlight
Do not discontinue abruptly- comply with dosage schedule
Dizziness, fainting, light-headedness may occur-avoid hazardous
activities until reaction is known
To rise slowing to sitting or standing position to minimize orthostatic
hypotension
, Fetal Injury, Angioedema, renal failure,
NSG124 Pharmacology Drug Card Template
Who takes this? How does it work? Pharmacokinetics/How is it given?
Binds to mineralocorticoid receptor and
Hypertension, alone or in blocks the binding of aldosterone, a
combination with thiazide component of the rennin-angiotensin-
diuretics, HF, post-MI aldosterone system (RAAS)
Peak 1½ hr; serum protein binding
50%; half-life 4-6 hr; metabolized in
liver by CYP3A4; excreted in urine
<5%, feces
Who takes this? How does it work? Pharmacokinetics/How is it given?
Hypertension, diabetic Blocks production of angiotensin II
nephropathy, heart failure,
MI
PO
Excreted in the urine
Peak 1 hr; duration 2-6 hr; half-life <2
hr, increased in renal disease
Contraindications Drug & Class How does the nurse know it is working?
Pregnancy and Breastfeeding, 1. Captopril [Capten] 9.1 + 9.4 + 9.5
children, potassium-sparing
diuretics Angiotensin-Converting Enzyme (ACE)
Inhibitor
Decrease in B/P, decreased diabetic
nephropathy symptoms, Improve
hemodynamics in patients with heart
failure
Nursing Considerations: Adverse Effects
What is the nurse going to do/teach/assess?
Should be administered 1 hour before meals or 2 hr after meals
Do not discontinue product abruptly – adhere to dosage schedule, even if
feeling better.
Warn patients about the possibility of persistent cough - avoid OTC
Hyperkalemia may occur – avoid potassium supplement and potassium-
containing salt substitutes
Signs and symptoms of
angioedema Signs and symptoms
of neutropenia
, Cough – persistent dry, irritating,
nonproductive, Neutropenia,
Angioedema
NSG124 Pharmacology Drug Card Template
Who takes this? How does it work? Pharmacokinetics/How is it given?
Patients with hypertension, Blocks the actions of angiotensin II
diabetic nephropathy,
Oral – may be taken with or without food
Peak 1 hr; half-life 2 hr;
, prevention, diabetic
retinopathy
Excreted in urine/feces
Contraindications Drug & Class How does the nurse know it is working?
Pregnancy-during the 2nd and 1. Losartan [Cozaar]9.1 + 9.4 + 9.5
3rd trimesters, Bilateral renal
artery stenosis, a history of Antihypertensive
hypersensitivity reactions Angiotensin II receptor antagonist
Decreased B/P
Decrease diabetic
nephropathy
Nursing Considerations: Adverse Effects
What is the nurse going to do/teach/assess?
Photosensitivity may occur- avoid sunlight, wear sunscreen if in sunlight
Do not discontinue abruptly- comply with dosage schedule
Dizziness, fainting, light-headedness may occur-avoid hazardous
activities until reaction is known
To rise slowing to sitting or standing position to minimize orthostatic
hypotension
, Fetal Injury, Angioedema, renal failure,
NSG124 Pharmacology Drug Card Template
Who takes this? How does it work? Pharmacokinetics/How is it given?
Binds to mineralocorticoid receptor and
Hypertension, alone or in blocks the binding of aldosterone, a
combination with thiazide component of the rennin-angiotensin-
diuretics, HF, post-MI aldosterone system (RAAS)
Peak 1½ hr; serum protein binding
50%; half-life 4-6 hr; metabolized in
liver by CYP3A4; excreted in urine
<5%, feces
