Exam 1: Cardiovascular
Pharmacotherapy
What is the MOA of amiodarone (Cordarone)? - Answer Converts back to sinus rhythm
What are the toxicities associated with amiodarone (Cordarone)? - Answer Pulmonary
-fibrosis long-term
Cardiotoxicity
-heart damage
Visual
-impairment
-most people get blurry vision
How is amiodarone (Cordarone) eliminated from the body? - Answer This is a substrate
of the CYP3A4 system, so watch for drug interactions.
What is the MOA of dofeltilide (Tikosyn)? - Answer Delays repolarization by slowing the
return of ions to their normal place
AE of dofetilide (Tikosyn) - Answer -prolonged QT interval
**Torsades de pointes
What are the possible drug interaction considerations for dofetilide (Tikosyn)? - Answer
Avoid drugs that prolong the QT interval.
Safety considerations for Amiodaronde (Cordarone) - Answer §Pulmonary toxicity and
liver injury
§Make dysrhythmia worse
§Continuous ECG monitoring when initiating
What are the safety considerations or Dofetilide (Tikosyn)? - Answer -Keep hospitalized
for 3 days with continuous ECG
-Calculate creatinine clearance (make sure kidneys are working)
-Prolonged QT interval, torsades de pointes (ventricular dysrhythmias)
Atropine - Answer For symptomatic bradycardia
Adenosine - Answer For PSVT to stop the heart/interrupt the abnormal activity, so it can
restart normally.
Pharmacotherapy
What is the MOA of amiodarone (Cordarone)? - Answer Converts back to sinus rhythm
What are the toxicities associated with amiodarone (Cordarone)? - Answer Pulmonary
-fibrosis long-term
Cardiotoxicity
-heart damage
Visual
-impairment
-most people get blurry vision
How is amiodarone (Cordarone) eliminated from the body? - Answer This is a substrate
of the CYP3A4 system, so watch for drug interactions.
What is the MOA of dofeltilide (Tikosyn)? - Answer Delays repolarization by slowing the
return of ions to their normal place
AE of dofetilide (Tikosyn) - Answer -prolonged QT interval
**Torsades de pointes
What are the possible drug interaction considerations for dofetilide (Tikosyn)? - Answer
Avoid drugs that prolong the QT interval.
Safety considerations for Amiodaronde (Cordarone) - Answer §Pulmonary toxicity and
liver injury
§Make dysrhythmia worse
§Continuous ECG monitoring when initiating
What are the safety considerations or Dofetilide (Tikosyn)? - Answer -Keep hospitalized
for 3 days with continuous ECG
-Calculate creatinine clearance (make sure kidneys are working)
-Prolonged QT interval, torsades de pointes (ventricular dysrhythmias)
Atropine - Answer For symptomatic bradycardia
Adenosine - Answer For PSVT to stop the heart/interrupt the abnormal activity, so it can
restart normally.
