USMLE Step 1 Rapid Review Questions And Answers
Graded A 2022
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) Correct Answer: Budd-
Chiari syndrome
Achilles tendon xanthoma Correct Answer: Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC Correct Answer: Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints Correct Answer: Marfan's
(fibrillin defect)
Athlete with polycythemia Correct Answer: Erythropoietin injection
Back pain, fever, night sweats, weight loss Correct Answer: Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis Correct Answer: Sarcoid
Blue sclera Correct Answer: Osteogenesis imperfecta
Bluish line on gingiva Correct Answer: Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) Correct
Answer: Paget's
Bounding pulses, diastolic hear murmur, head bobbing Correct Answer: Aortic regurg
Café-au-lait spots, Lisch nodules Correct Answer: NF (1 = optic glimoas and pheo, 2 = acoustic
Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty Correct Answer: McCune-Albright
syndome (G protein problem)
Calf pseudohypertrophy Correct Answer: Duchenne's muscular dystrophy
Cherry-red spot on macula Correct Answer: Tay-Sachs, Niemann-Pick, central retinal artery occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI Correct Answer: Dressler's
(autoimmune post-MI)
Child uses arms to stand up from squat Correct Answer: Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body Correct Answer: Slapped cheek - B19
Chorea, dementia, caudate degeneration Correct Answer: Huntington's
, Chronic exercise intolerance with myalgia, fatigue, painful cramps Correct Answer: McArdle's (muscle
phosphorylase deficiency)
Cold intolerance Correct Answer: Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia Correct Answer: Internuclear ophthalmoplegia (MS or
stroke)
Continuous machinery heart murmur Correct Answer: PDA
Cutaneous/dermal edema due to CT expansion Correct Answer: Myxedema
Dark purple skin / mouth nodules Correct Answer: Kaposi's sarcoma
Deep, labored breathing / hyperventilation Correct Answer: Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea Correct Answer: Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy Correct Answer: Wet beriberi (B1 / thiamine
deficiency)
Dog or cat bite resulting in infection Correct Answer: Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis Correct Answer: Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia Correct Answer:
Plummer-Vinson syndrome
Elastic skin, hypermobility of joints Correct Answer: Ehler-Danlos (type III collagen)
Enlarged. hard left supraclavicular node Correct Answer: VIrchow's node (abdominal met)
Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells Correct Answer: Sezary
syndrome (cutaneous T cell lymphoma)
Facial muscle spasm upon tapping Correct Answer: Chvostek's sign (hypocalcemia)
Fat, female, fertile, forty Correct Answer: Gallstones
Fever, chills, headache, myalgia following antibiotic treatment for syphillis Correct Answer: Jarisch-
Herxheimer reaction (lysis of spirochetes results in toxin release)
Fever, cough, conjunctivitis, coryza, diffuse rash, Koplick spots Correct Answer: Measles
Fever, night sweats, weight loss Correct Answer: B symptoms or TB
Fibrous plaques in soft tissue of penis Correct Answer: Peyronie's disease
Graded A 2022
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) Correct Answer: Budd-
Chiari syndrome
Achilles tendon xanthoma Correct Answer: Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC Correct Answer: Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints Correct Answer: Marfan's
(fibrillin defect)
Athlete with polycythemia Correct Answer: Erythropoietin injection
Back pain, fever, night sweats, weight loss Correct Answer: Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis Correct Answer: Sarcoid
Blue sclera Correct Answer: Osteogenesis imperfecta
Bluish line on gingiva Correct Answer: Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) Correct
Answer: Paget's
Bounding pulses, diastolic hear murmur, head bobbing Correct Answer: Aortic regurg
Café-au-lait spots, Lisch nodules Correct Answer: NF (1 = optic glimoas and pheo, 2 = acoustic
Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty Correct Answer: McCune-Albright
syndome (G protein problem)
Calf pseudohypertrophy Correct Answer: Duchenne's muscular dystrophy
Cherry-red spot on macula Correct Answer: Tay-Sachs, Niemann-Pick, central retinal artery occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI Correct Answer: Dressler's
(autoimmune post-MI)
Child uses arms to stand up from squat Correct Answer: Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body Correct Answer: Slapped cheek - B19
Chorea, dementia, caudate degeneration Correct Answer: Huntington's
, Chronic exercise intolerance with myalgia, fatigue, painful cramps Correct Answer: McArdle's (muscle
phosphorylase deficiency)
Cold intolerance Correct Answer: Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia Correct Answer: Internuclear ophthalmoplegia (MS or
stroke)
Continuous machinery heart murmur Correct Answer: PDA
Cutaneous/dermal edema due to CT expansion Correct Answer: Myxedema
Dark purple skin / mouth nodules Correct Answer: Kaposi's sarcoma
Deep, labored breathing / hyperventilation Correct Answer: Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea Correct Answer: Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy Correct Answer: Wet beriberi (B1 / thiamine
deficiency)
Dog or cat bite resulting in infection Correct Answer: Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis Correct Answer: Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia Correct Answer:
Plummer-Vinson syndrome
Elastic skin, hypermobility of joints Correct Answer: Ehler-Danlos (type III collagen)
Enlarged. hard left supraclavicular node Correct Answer: VIrchow's node (abdominal met)
Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells Correct Answer: Sezary
syndrome (cutaneous T cell lymphoma)
Facial muscle spasm upon tapping Correct Answer: Chvostek's sign (hypocalcemia)
Fat, female, fertile, forty Correct Answer: Gallstones
Fever, chills, headache, myalgia following antibiotic treatment for syphillis Correct Answer: Jarisch-
Herxheimer reaction (lysis of spirochetes results in toxin release)
Fever, cough, conjunctivitis, coryza, diffuse rash, Koplick spots Correct Answer: Measles
Fever, night sweats, weight loss Correct Answer: B symptoms or TB
Fibrous plaques in soft tissue of penis Correct Answer: Peyronie's disease
