BIO 1200 BIOCHEMISTRYBLUE-PACOP
BIOCHEMISTRY BLUE-PACOP
__ 1. What two enzymes are used to bypass the pyruvate kinase reaction of glycolysis?
I. pyruvate carboxylase
II. PEP carboxykinase
III. Fructose biphosphatase
IV. Glucose-6-phosphate
A. I & II D. II & IV
B. III & IV E. II & III
C. I &III
__ 2. Which of the following includes the main goals of Pentose Phosphate Pathway?
I. produce ribose-5-phosphate for nucleotide synthesis
II. produce NADPH and NADP for oxidoreductive biochemical synthesis
III. to interconvert pentoses and hexoses
A. I & II D. I, II & III
B. II & III
C. I & III
__ 3. Which of the following statements is/are true regarding the secondary structure of
nucleic acids?
I. Guanine forms base pairs with cytosine via 2 hydrogen bonds
II. The B form of the DNA is the most common in biological systems
III. The breaking of H-bonds caused by high temperature is called melting
A. I,II & III D. I & II
B. I & II E. II only
C. II & III
__ 4. The phospholipid, phosphatidylinositol 4,5-biphosphate forms the potent secondary
messengers inositol triphosphate & diacylglycerol via what enzyme?
A. Phospholipase A D. Phospholipase B
B. Phospholipase C
C. Phospholipase D
__ 5. Which of the following is not true regarding the four enzyme complexes of the electron
transport chain?
A. Complex I is known as the NADH-CoQ Oxidoreductases
B. Complex II is known as Succinate-CoQ Oxidoreductases
C. Complex III is known as Cytochrome Oxidase
D. Complex IV is known as Cytochrome Oxidase
__ 6. Glucose and mannose are epimers at:
A. Carbon 4 C. Carbon 3
B. Carbon 2 D. Carbon 5
__ 7. One important endogenous molecule for synthetic biotransformation of xenobiotics is
glucoronic acid. It is actually the most dominant conjugative biotransformation pathway due to the
readily available source of glucose. It is produce from glucose via:
A. Oxidation at carbon 1 C. Oxidation at carbon 6
B. Oxidation at carbon 2 D. Oxidation at carbon 1 & 6
__ 8. Which of the following is not true about protein structure determination?
A. NMR is the primary means of determining protein structure
B. Protein are difficult to crystallize, a disadvantage of x-ray crystallography
C. An advantage of the use of the NMR is that proteins analyzed are in their natural state
, D. Large and very complex proteins can only be analyzed by x-ray crystallography
__ 9. Tertiary structures of proteins are primarily stabilized by
I. H-bonds
II. Hydrophobic interactions
III. Ionic bonds
IV. Disulfide bonds
A. I & III D. I, II& IV
B. II & IV E. II, III & IV
C. I,III & IV
__ 10. In an uncompetitive inhibition of enzymatic action :
A. Inhibitor binds either to the free enzyme or the enzyme substrate complex
B. Lineweaver-Burk plots of the enzyme alone (control) & the enzyme + inhibitor are
parallel to each other
C. The apparent Km is raised
D. The Vmax is unaffected
__ 11. Which biomolecule is not considered a biopolymer?
A. Proteins D. Nucleic acids
B. Lipids E. Fat
C. Carbohydrates
__ 12. It is regarded as the universal biological energy currency
A. Adenosine triphosphate C. Uncouplers
B. Guanosine triphosphate D. Calories
__ 13. This is the final electron receptor of the electron transport chain
A. Complex I C. Complex V
B. Complex II D. Complex IV
__ 14. The most accepted hypothesis regarding oxidative phosphorylation is
A. Chemical coupling D. Lock and Key Theory
B. Conformational coupling E. Diffusion
C. Chemiostatic hypothesis
__ 15. This is a quantitative study of the energy transformationsin the living cell
A. Bioenergetics C. Proteonomics
B. Thermodynamics D. Metabolomics
__ 16. Which of the following hormones promotes rapid glycogenolysis in both liver and muscle
A. ACTH C. Epinephrine
B. Glutemine D. Prolactin
__ 17. Which vitamin can be used in the management of hyperlipidemia?
A. Thiamine C. Niacin
B. Riboflavin D. Panthotenic acid
__ 18. Bond between 2 amino acids
A. Glycosidic bond C. Peptide Bond
B. N-glycosyl linkage D. Hydrogen bond
__ 19. Beta oxidation of fatty acids occurs in the
A. Cytosol C. Endoplasmic reticulum
B. Mitochondria D. Ribosomes
,__ 20. The pentose phosphate pathway occur in the ________ of the liver, muscle and kidney.
A. cytosol C. endoplasmic reticulum
B. mitochondria D. ribosomes
__ 21. The isoelctric point is the
A. pH where the alpha amino acid exist in its negatively charged form
B. pH wherein the amino acid exist in zwitterionic form
C. Temperature at which the amino acid denatures
D. Pressure at which the amino acid hydrolyzes
__ 22. This is the only optically inactive amino acid
A. methionine C. Citrulline
B. Lysine D. glycine
__ 23. This level of protein structure is applicable only to those have several subunits
A. Primary C. Tertiary
B. Secondary D. Quaternary
__ 24. Arginine is the only metabolite of the urea cycle that does not accumulate because
A. It is readily excreted
B. It is used up by the body for protein synthesis
C. There is no known deficiency in the enzyme that catabolizes it
D. It can ve acquired from food
__ 25. This is the genetic condition characterized by deficiency of the enzyme branched chain
alpha-keto acid dehydrogenase
A. Maple syrup disease C. Kwashiorkor
B. Hartnup disease D. Marasmus
__ 26. These are compounds related to cerebrosides that contain sphingsine, long chain fatty
acids, hexoses (usually galactose or glucose) and neuramic acid
A. cephalins C. cytolipins
B. gangliosides D. lecithins
__ 27. This enzyme catalyzes the conversion fructose-6-P to fructose-1,6-bis-P
A. hexokinase C. PFK
B. pyruvate kinase D. glyceraldehyde phosphate dehydrogenase
__ 28. Which of the following is called transamination?
A. Conversion of amino acids to hydroxyl groups
B. Conversion of amino acids to keto acids
C. Loss of ammonia from amino acids
D. Formation of ammonium salts from ammonia
E.
__ 29. The sugar involved in the DNA
A. ribose C. deoxyribose
B. pentose D. xylose
__ 30. Thisis the reason why blood AB is considered as the universal recipient.
A. It is the most common among the ABO blood types
B. Blood type AB has neither A nor B substances
C. Blood type AB has either anti-A nor anti-B antibodies
D. All of the above
__ 31. Which one is true regarding the structures of lipids?
, A.Eicosanopentanoic acid is a saturated fatty acid
B. They may exist as esters of cholesterol when they are enclosed in very low density
C. Linoleic acid is an omega-3 fatty acid
D. Capric acid contains 12 carbons
__ 32. This is the product of basic hydrolysis of fats and oils
A. fatty acid C. soap
B. triacylglycerol D. detergent
__ 33. The group of lipids is considered amphipathic
A. sterols C. trans-fatty acids
B. fatty acids D. phospholipids
__ 34. Which properly describes a liposome?
A. It is a hollow sphere-like structure composed of a lipid bilayer enclosing an
aqueous cavity
B. It is a lipid structure wherein the hydrophobic chains of the fatty acids are
sequestered at the core of the sphere with virtually no water in the hydrophobic interior
C. It is a lipoprotein integrated in the phosphopolipid bilayer of the cell membranes
D. It is a hollow sphere-like structure composed of a lipid monolayer enclosing a
hrdrophobic cavity
__ 35. It is the building block of essential fatty acids
A. Malonyl CoA C. Acetyl CoA
B.phosphoribosyl pyrophosphate D. HMG CoA
__ 36. The digestion of carbohydrates begins in the________.
A. mouth C. small intestine
B. stomach D. duodenum
__ 37. Cellular elements of the blood devoid of nucleus
A. RBC C. thrombocytes
B. WBC D. all of the above
__ 38. Conjugated proteins which are a combination of amino acids and carbohydrates
A. nucleoproteins C. phosphoproteins
B. glycoproteins D. chromoproteins
__ 39. Glucose is normally absent in the urine because kidneys normally completely reabsorb all
glucose. Which of the following is true?
A. Glucosuria confirms diabetes mellitus
B. Glucosuria necessarily means hyperglycemia
C. Glucosuria is solely attributed to insulin problem
D. Glucosuria may occur in other disease states
__ 40. Wernicke-Korsakoff syndrome which can cause acute confusion, ataxia and
opthalmoplegia, can be treated with which of the following?
A. riboflavin C. thiamine
B. ascorbic acid D. pantothenic acid
__ 41. This is the major excretory product of purine nucleotides
A. inosine monophosphate C. methylmalonyl CoA
B. uric acid D. tetrahydrofolate
__ 42. This is the phenomena of renaturation of nucleic acid after it has been subjected to high
then to room temperature
BIOCHEMISTRY BLUE-PACOP
__ 1. What two enzymes are used to bypass the pyruvate kinase reaction of glycolysis?
I. pyruvate carboxylase
II. PEP carboxykinase
III. Fructose biphosphatase
IV. Glucose-6-phosphate
A. I & II D. II & IV
B. III & IV E. II & III
C. I &III
__ 2. Which of the following includes the main goals of Pentose Phosphate Pathway?
I. produce ribose-5-phosphate for nucleotide synthesis
II. produce NADPH and NADP for oxidoreductive biochemical synthesis
III. to interconvert pentoses and hexoses
A. I & II D. I, II & III
B. II & III
C. I & III
__ 3. Which of the following statements is/are true regarding the secondary structure of
nucleic acids?
I. Guanine forms base pairs with cytosine via 2 hydrogen bonds
II. The B form of the DNA is the most common in biological systems
III. The breaking of H-bonds caused by high temperature is called melting
A. I,II & III D. I & II
B. I & II E. II only
C. II & III
__ 4. The phospholipid, phosphatidylinositol 4,5-biphosphate forms the potent secondary
messengers inositol triphosphate & diacylglycerol via what enzyme?
A. Phospholipase A D. Phospholipase B
B. Phospholipase C
C. Phospholipase D
__ 5. Which of the following is not true regarding the four enzyme complexes of the electron
transport chain?
A. Complex I is known as the NADH-CoQ Oxidoreductases
B. Complex II is known as Succinate-CoQ Oxidoreductases
C. Complex III is known as Cytochrome Oxidase
D. Complex IV is known as Cytochrome Oxidase
__ 6. Glucose and mannose are epimers at:
A. Carbon 4 C. Carbon 3
B. Carbon 2 D. Carbon 5
__ 7. One important endogenous molecule for synthetic biotransformation of xenobiotics is
glucoronic acid. It is actually the most dominant conjugative biotransformation pathway due to the
readily available source of glucose. It is produce from glucose via:
A. Oxidation at carbon 1 C. Oxidation at carbon 6
B. Oxidation at carbon 2 D. Oxidation at carbon 1 & 6
__ 8. Which of the following is not true about protein structure determination?
A. NMR is the primary means of determining protein structure
B. Protein are difficult to crystallize, a disadvantage of x-ray crystallography
C. An advantage of the use of the NMR is that proteins analyzed are in their natural state
, D. Large and very complex proteins can only be analyzed by x-ray crystallography
__ 9. Tertiary structures of proteins are primarily stabilized by
I. H-bonds
II. Hydrophobic interactions
III. Ionic bonds
IV. Disulfide bonds
A. I & III D. I, II& IV
B. II & IV E. II, III & IV
C. I,III & IV
__ 10. In an uncompetitive inhibition of enzymatic action :
A. Inhibitor binds either to the free enzyme or the enzyme substrate complex
B. Lineweaver-Burk plots of the enzyme alone (control) & the enzyme + inhibitor are
parallel to each other
C. The apparent Km is raised
D. The Vmax is unaffected
__ 11. Which biomolecule is not considered a biopolymer?
A. Proteins D. Nucleic acids
B. Lipids E. Fat
C. Carbohydrates
__ 12. It is regarded as the universal biological energy currency
A. Adenosine triphosphate C. Uncouplers
B. Guanosine triphosphate D. Calories
__ 13. This is the final electron receptor of the electron transport chain
A. Complex I C. Complex V
B. Complex II D. Complex IV
__ 14. The most accepted hypothesis regarding oxidative phosphorylation is
A. Chemical coupling D. Lock and Key Theory
B. Conformational coupling E. Diffusion
C. Chemiostatic hypothesis
__ 15. This is a quantitative study of the energy transformationsin the living cell
A. Bioenergetics C. Proteonomics
B. Thermodynamics D. Metabolomics
__ 16. Which of the following hormones promotes rapid glycogenolysis in both liver and muscle
A. ACTH C. Epinephrine
B. Glutemine D. Prolactin
__ 17. Which vitamin can be used in the management of hyperlipidemia?
A. Thiamine C. Niacin
B. Riboflavin D. Panthotenic acid
__ 18. Bond between 2 amino acids
A. Glycosidic bond C. Peptide Bond
B. N-glycosyl linkage D. Hydrogen bond
__ 19. Beta oxidation of fatty acids occurs in the
A. Cytosol C. Endoplasmic reticulum
B. Mitochondria D. Ribosomes
,__ 20. The pentose phosphate pathway occur in the ________ of the liver, muscle and kidney.
A. cytosol C. endoplasmic reticulum
B. mitochondria D. ribosomes
__ 21. The isoelctric point is the
A. pH where the alpha amino acid exist in its negatively charged form
B. pH wherein the amino acid exist in zwitterionic form
C. Temperature at which the amino acid denatures
D. Pressure at which the amino acid hydrolyzes
__ 22. This is the only optically inactive amino acid
A. methionine C. Citrulline
B. Lysine D. glycine
__ 23. This level of protein structure is applicable only to those have several subunits
A. Primary C. Tertiary
B. Secondary D. Quaternary
__ 24. Arginine is the only metabolite of the urea cycle that does not accumulate because
A. It is readily excreted
B. It is used up by the body for protein synthesis
C. There is no known deficiency in the enzyme that catabolizes it
D. It can ve acquired from food
__ 25. This is the genetic condition characterized by deficiency of the enzyme branched chain
alpha-keto acid dehydrogenase
A. Maple syrup disease C. Kwashiorkor
B. Hartnup disease D. Marasmus
__ 26. These are compounds related to cerebrosides that contain sphingsine, long chain fatty
acids, hexoses (usually galactose or glucose) and neuramic acid
A. cephalins C. cytolipins
B. gangliosides D. lecithins
__ 27. This enzyme catalyzes the conversion fructose-6-P to fructose-1,6-bis-P
A. hexokinase C. PFK
B. pyruvate kinase D. glyceraldehyde phosphate dehydrogenase
__ 28. Which of the following is called transamination?
A. Conversion of amino acids to hydroxyl groups
B. Conversion of amino acids to keto acids
C. Loss of ammonia from amino acids
D. Formation of ammonium salts from ammonia
E.
__ 29. The sugar involved in the DNA
A. ribose C. deoxyribose
B. pentose D. xylose
__ 30. Thisis the reason why blood AB is considered as the universal recipient.
A. It is the most common among the ABO blood types
B. Blood type AB has neither A nor B substances
C. Blood type AB has either anti-A nor anti-B antibodies
D. All of the above
__ 31. Which one is true regarding the structures of lipids?
, A.Eicosanopentanoic acid is a saturated fatty acid
B. They may exist as esters of cholesterol when they are enclosed in very low density
C. Linoleic acid is an omega-3 fatty acid
D. Capric acid contains 12 carbons
__ 32. This is the product of basic hydrolysis of fats and oils
A. fatty acid C. soap
B. triacylglycerol D. detergent
__ 33. The group of lipids is considered amphipathic
A. sterols C. trans-fatty acids
B. fatty acids D. phospholipids
__ 34. Which properly describes a liposome?
A. It is a hollow sphere-like structure composed of a lipid bilayer enclosing an
aqueous cavity
B. It is a lipid structure wherein the hydrophobic chains of the fatty acids are
sequestered at the core of the sphere with virtually no water in the hydrophobic interior
C. It is a lipoprotein integrated in the phosphopolipid bilayer of the cell membranes
D. It is a hollow sphere-like structure composed of a lipid monolayer enclosing a
hrdrophobic cavity
__ 35. It is the building block of essential fatty acids
A. Malonyl CoA C. Acetyl CoA
B.phosphoribosyl pyrophosphate D. HMG CoA
__ 36. The digestion of carbohydrates begins in the________.
A. mouth C. small intestine
B. stomach D. duodenum
__ 37. Cellular elements of the blood devoid of nucleus
A. RBC C. thrombocytes
B. WBC D. all of the above
__ 38. Conjugated proteins which are a combination of amino acids and carbohydrates
A. nucleoproteins C. phosphoproteins
B. glycoproteins D. chromoproteins
__ 39. Glucose is normally absent in the urine because kidneys normally completely reabsorb all
glucose. Which of the following is true?
A. Glucosuria confirms diabetes mellitus
B. Glucosuria necessarily means hyperglycemia
C. Glucosuria is solely attributed to insulin problem
D. Glucosuria may occur in other disease states
__ 40. Wernicke-Korsakoff syndrome which can cause acute confusion, ataxia and
opthalmoplegia, can be treated with which of the following?
A. riboflavin C. thiamine
B. ascorbic acid D. pantothenic acid
__ 41. This is the major excretory product of purine nucleotides
A. inosine monophosphate C. methylmalonyl CoA
B. uric acid D. tetrahydrofolate
__ 42. This is the phenomena of renaturation of nucleic acid after it has been subjected to high
then to room temperature
