NR 566 Final Exam Review 2022 Advanced Pharmacology

NR 566 Final Exam Review 2022 Advanced Pharmacology 1. macrolide drugs - erythromycin - clarithromycin - dirithromycin - azithromycin - telithromycin 2. Pharmacodynamics of macrolides - Interferes with steps involves in protein synthesis thereby rendering cell division non-functional 3. macrolides are active against - gram (+) organisms & gram (-) organisms 4. Macrolide indications - CAP (DOC) - legionella PNA (DOC) - pertussis - chronic bronchitis - chlamydia - H. pylori - Group A Strep - mycobacterium avium complex - endocarditis prophylaxis 5. Macrolide drug interactions - CYP450 & 3A4 inhibitors - statins - theophylline - colchicine - carbamazepine 6. sulfonamide drugs - sulfasalazine - mafenide - silver sulfasalazine - combinations: - trimethoprim/sulamethoxazole (Bactrim) 7. sulfonamide drugs active against - Grams (+) & Gram (-) 8. sulfonamide indications - Ulcerative colitis - ocular infections - burn infections - toxoplasmosis - chronic bacterial proctitis - prevention of UTIs in women 9. Pharmacodynamics of sulfonamides - Inhibits invading organisms from using substances essential to their growth and development; block folic acid synthesis 10. Trimethoprim mechanism of action - inhibits DNA synthesis 11. Trimethoprim active against - gram (-) & gram (+) organisms 12. Nitrofurantoin mechanism of action - inhibits acetyl co-enzymes 13. Nitrofurantoin active against - gram (-) & gram (+) organisms 14. sulfonamide drug interactions - sulfonylureas - methotrexate - cyclosporine - hydantoins - probenecid - thiazide diuretics - warfarin 15. nitrofurantoin drug interactions - probenecid