Portage Pathophysiology Module 2
Problem Set
Define Neoplasia - Answer means new growth
Define Neoplasm - Answer means the new growth itself
Define Proliferation - Answer process of cell division where new cell growth replaces old
cells or when additional cells are needed
Define Differentiation - Answer the process by which cells become more specialized
with each mitotice division
Describe the cell cycle - Answer G1 to S phase to G2 to M phase
What are the 3 main groups of cells that proliferate? - Answer 1. well differentiated
neurons and cells of skeletal and cardiac muscles that rarely divide and reproduce
2. progenitor or parent cells that continue to divide and reproduce, such as blood, skin,
and liver cells
3. undifferentiated stem cells that can enter the cell cycle and produce large numbers of
progenitor cells if needed
What are progenitor cells? - Answer biological cell that has a tendency to differentiate
into a specific type of cell, but is already more specific than a stem cell and is pushed to
differentiate into its "target" cell
What are the benefits of the stem cell? - Answer self-renewal and potency meaning they
can undergo numerous mitotic divisions while maintaining an undifferentiated state and
they vary in differentiation potential
What is the difference between malignant and benign tumors? - Answer Malignant
tumors invade and destory tissue, growing rapidly and spreading to other parts of the
body
Benign tumors grow by expansion and remain localized to their site of origin, not
capable of metastising
What is polyp? - Answer growth that projects from a mucosal surface (like the intestine);
malignant or benign
Metastasis - Answer The spread of cancer cells beyond their point of tissue origin
What are the 2 broad categories of malignant neoplasms? - Answer 1. solid tumors
2. hematologic cancers
Problem Set
Define Neoplasia - Answer means new growth
Define Neoplasm - Answer means the new growth itself
Define Proliferation - Answer process of cell division where new cell growth replaces old
cells or when additional cells are needed
Define Differentiation - Answer the process by which cells become more specialized
with each mitotice division
Describe the cell cycle - Answer G1 to S phase to G2 to M phase
What are the 3 main groups of cells that proliferate? - Answer 1. well differentiated
neurons and cells of skeletal and cardiac muscles that rarely divide and reproduce
2. progenitor or parent cells that continue to divide and reproduce, such as blood, skin,
and liver cells
3. undifferentiated stem cells that can enter the cell cycle and produce large numbers of
progenitor cells if needed
What are progenitor cells? - Answer biological cell that has a tendency to differentiate
into a specific type of cell, but is already more specific than a stem cell and is pushed to
differentiate into its "target" cell
What are the benefits of the stem cell? - Answer self-renewal and potency meaning they
can undergo numerous mitotic divisions while maintaining an undifferentiated state and
they vary in differentiation potential
What is the difference between malignant and benign tumors? - Answer Malignant
tumors invade and destory tissue, growing rapidly and spreading to other parts of the
body
Benign tumors grow by expansion and remain localized to their site of origin, not
capable of metastising
What is polyp? - Answer growth that projects from a mucosal surface (like the intestine);
malignant or benign
Metastasis - Answer The spread of cancer cells beyond their point of tissue origin
What are the 2 broad categories of malignant neoplasms? - Answer 1. solid tumors
2. hematologic cancers
