Minor: Mystery of creation
Inhoud
HC1.1 Introductie ................................................................................................................................... 5
HC2.1 Intro verloskunde – Suzanne Peeters .......................................................................................... 5
Hormonen .......................................................................................................................................... 6
Geen bevruchting ............................................................................................................................... 8
Wel bevruchting ................................................................................................................................. 8
Voorwaarden voor bevruchting ......................................................................................................... 8
Zwangerschap .................................................................................................................................... 8
Gezond zwanger ................................................................................................................................. 9
Controles ............................................................................................................................................ 9
HC1.3a Intro voortplantingsgeneeskunde – Jits Schipper .................................................................... 10
Voorwaarden voor conceptie ........................................................................................................... 10
Behandelopties afwegen .................................................................................................................. 11
Behandelopties bij probleem zaadcel .............................................................................................. 11
Behandelopties bij probleem eicel ................................................................................................... 11
Behandelopties bij probleem toegang tot elkaar ............................................................................. 11
Behandelopties bij onbegrepen infertiliteit ..................................................................................... 11
HC1.3b Intro IVF – Jits Schipper............................................................................................................ 11
Feiten over IVF ................................................................................................................................. 11
Indicaties voor IVF ............................................................................................................................ 11
4 fasen van IVF ................................................................................................................................. 12
Aanvullende technieken ................................................................................................................... 12
Beperkingen/nadelen IVF ................................................................................................................. 12
HC 1.4a Intro neonatologie – Nikk Conneman ..................................................................................... 13
Prematuriteit .................................................................................................................................... 13
Beademen neonaat .......................................................................................................................... 14
Family-centered care ........................................................................................................................ 14
HC 1.4b Inleiding neonatologie – René Kornelisse ............................................................................... 14
Aandoeningen bij neonaten ............................................................................................................. 16
Mortaliteit kinderen <5 jaar ............................................................................................................. 17
HC 1.6 Intro epigenetica – Joost Gribnau ............................................................................................. 17
HC 1.9 The magical hour – N. Conneman & E. Fitzpatrick .................................................................... 19
9 stadia in het eerste uur na de geboorte ........................................................................................ 19
HC 2.1 Belang en werkingsmechanismen van voeding – A. Verhoeven ............................................... 20
, Verhoogde nutriëntbehoefte ........................................................................................................... 20
Kritische fase .................................................................................................................................... 21
Metabole veranderingen tijdens zwangerschap .............................................................................. 21
Nutriëntentransport door de placenta ............................................................................................. 22
Borstvoeding .................................................................................................................................... 23
HC 2.2 Praktische voedingsadviezen – dr. Ir. L. van Rossem ................................................................ 24
Te beperken producten .................................................................................................................... 24
Te vermijden producten ................................................................................................................... 25
Vegetariërs/veganisten .................................................................................................................... 25
Veranderde behoefte ....................................................................................................................... 25
HC 2.3 Basisprincipes gezonde voeding – M. van Kemenade ............................................................... 25
Mediterraan dieet ............................................................................................................................ 26
HC 2.4 Periconceptional and embryonic health – ................................................................................ 26
HC 2.5 Nutritional assessment – Elmi Wopereis .................................................................................. 27
HC 2.8 Roken, zwangerschap en het kind – Jasper Been ...................................................................... 28
Feiten over roken ............................................................................................................................. 28
Risico’s van roken tijdens zwangerschap .......................................................................................... 29
Risico’s van roken na geboorte ........................................................................................................ 29
Maatregelen WHO ........................................................................................................................... 29
Alcohol ............................................................................................................................................. 29
HC 2.10 Mindfulness – Rianne vd Kleij ................................................................................................. 31
HC 2.11 Zwangerschap: overgewicht, leefstijl en bariatrie – dr. S. Schoenmakers .............................. 32
HC2.11 Borstvoeding – M.J. Vermeulen ............................................................................................... 33
Voedingsmethoden .......................................................................................................................... 33
Moedermelk vs. Kunstvoeding ......................................................................................................... 33
Voordelen voor moeder ................................................................................................................... 34
HC3.1 Periconceptionele periode en embryonale gezondheid – Melek Rousian ................................. 34
PREDICT STUDY: ............................................................................................................................... 34
HC 3.2 Circadiaanse klok – Inês Chaves ................................................................................................ 35
Consequenties verstoring circadiaan ritme ...................................................................................... 36
Slaapstoornissen .............................................................................................................................. 36
Muizenstudie.................................................................................................................................... 36
HC 3.3 Inleiding IVF – Esther Baart ....................................................................................................... 37
Semenkwaliteit beoordelen ............................................................................................................. 37
Eicelrijping ........................................................................................................................................ 37
Bevruchting ...................................................................................................................................... 38
, Embryo kweek .................................................................................................................................. 38
Embryo selectie ................................................................................................................................ 38
HC3.4 VR voor biomedische visualisatie – dr. A.H.J. Koning ................................................................. 38
Echo 8-10 weken .............................................................................................................................. 38
20 weken echo ................................................................................................................................. 39
13 weken echo ................................................................................................................................. 39
HC 3.5 Cardiovasculaire gezondheid en zwangerschap – R. Bijl ........................................................... 39
Hemodynamische veranderingen tijdens de zwangerschap ............................................................ 39
Hemodynamische veranderingen tijdens de partus ......................................................................... 39
Placenta ............................................................................................................................................ 39
HC 3.6 Placenta – B. van Rijn ................................................................................................................ 40
HC 3.9 Geneesmiddelen in de zwangerschap – dr. Robert Flint ........................................................... 43
HC 3.10 Jonge zwangerschap – Lisa Lashley & A. Mulders ................................................................... 46
Miskraam ......................................................................................................................................... 48
Mola zwangerschap.......................................................................................................................... 48
Ectopische zwangerschap ................................................................................................................. 48
HC 3.11 Ovariële veroudering – dr. Y. Louwers .................................................................................... 48
HC 3.12 (Borst)kanker en zwangerschap – J. Duvekot.......................................................................... 49
HC 3.13 Genetica – Marieke Joosten .................................................................................................... 50
Genetische diagnostiek .................................................................................................................... 50
Hemofilie .......................................................................................................................................... 50
Beleid ............................................................................................................................................... 50
Myotone dystrofie/M. Steinert ........................................................................................................ 51
NIPT .................................................................................................................................................. 51
Noonan syndroom............................................................................................................................ 51
HC 3.14 Afvallen bij obesitas – G. Jiskoot ............................................................................................. 51
HC 3.15 Lifecourse medicine – prof. dr. A. Franx ................................................................................. 52
HC 4.1&4.2 Prenatale diagnostiek – Nina Peters.................................................................................. 52
Invasieve diagnostiek ....................................................................................................................... 52
Non-invasieve testen ........................................................................................................................ 53
HC4.5 Foetale therapie – Alex Eggink & Philip Dekoninck .................................................................... 53
Spina bifida ....................................................................................................................................... 54
Congenitale hernia diafragmatica (CHD) .......................................................................................... 55
Tweelingtransfusie syndroom (TTTS) ............................................................................................... 55
HC 4.6 Foetale en neonatale hersenontwikkeling – Fieke Husen ......................................................... 56
Normale hersenontwikkeling ........................................................................................................... 56
, Abnormale hersenontwikkeling ....................................................................................................... 56
HC 4.7 Foetale en neonatale hersenontwikkeling – Gerbrich v/d Bosch .............................................. 57
Vroege hersenontwikkeling .............................................................................................................. 57
Hersenstoornissen bij neonaten....................................................................................................... 57
HC 4.8 Asfyxie – R. Swarte .................................................................................................................... 58
HC 4.9 Dreigende vroeggeboorte – J. Duvekot ..................................................................................... 58
Uterus myometrium (spier) .............................................................................................................. 59
Vroeggeboorte ................................................................................................................................. 59
HC 4.10 Follow-up – R. Swarte ............................................................................................................. 59
HC 4.11 Neonatale neuroimaging – Gerbrich vd Bosch ........................................................................ 60
Echo.................................................................................................................................................. 60
HC 4.13 Ondervoeding bij kinderen – dr. K. Joosten ............................................................................ 60
HC 5.1 Anesthesie in de zwangerschap – dr. C. vd Marel ..................................................................... 61
HC 5.3a MOET – Jerome Cornette ........................................................................................................ 62
A ....................................................................................................................................................... 62
B ....................................................................................................................................................... 62
C ....................................................................................................................................................... 62
D ....................................................................................................................................................... 63
E ....................................................................................................................................................... 63
F........................................................................................................................................................ 63
HC 5.3b Newborn life support – Nanda van Paassen ........................................................................... 63
HC 5.4 Dakloze gezinnen – Liesbeth van Luijn ...................................................................................... 63
HC5.5 Hemodynamica van de neonaat – I. Reiss.................................................................................. 64
HC 6.3 ................................................................................................................................................... 64
Inhoud
HC1.1 Introductie ................................................................................................................................... 5
HC2.1 Intro verloskunde – Suzanne Peeters .......................................................................................... 5
Hormonen .......................................................................................................................................... 6
Geen bevruchting ............................................................................................................................... 8
Wel bevruchting ................................................................................................................................. 8
Voorwaarden voor bevruchting ......................................................................................................... 8
Zwangerschap .................................................................................................................................... 8
Gezond zwanger ................................................................................................................................. 9
Controles ............................................................................................................................................ 9
HC1.3a Intro voortplantingsgeneeskunde – Jits Schipper .................................................................... 10
Voorwaarden voor conceptie ........................................................................................................... 10
Behandelopties afwegen .................................................................................................................. 11
Behandelopties bij probleem zaadcel .............................................................................................. 11
Behandelopties bij probleem eicel ................................................................................................... 11
Behandelopties bij probleem toegang tot elkaar ............................................................................. 11
Behandelopties bij onbegrepen infertiliteit ..................................................................................... 11
HC1.3b Intro IVF – Jits Schipper............................................................................................................ 11
Feiten over IVF ................................................................................................................................. 11
Indicaties voor IVF ............................................................................................................................ 11
4 fasen van IVF ................................................................................................................................. 12
Aanvullende technieken ................................................................................................................... 12
Beperkingen/nadelen IVF ................................................................................................................. 12
HC 1.4a Intro neonatologie – Nikk Conneman ..................................................................................... 13
Prematuriteit .................................................................................................................................... 13
Beademen neonaat .......................................................................................................................... 14
Family-centered care ........................................................................................................................ 14
HC 1.4b Inleiding neonatologie – René Kornelisse ............................................................................... 14
Aandoeningen bij neonaten ............................................................................................................. 16
Mortaliteit kinderen <5 jaar ............................................................................................................. 17
HC 1.6 Intro epigenetica – Joost Gribnau ............................................................................................. 17
HC 1.9 The magical hour – N. Conneman & E. Fitzpatrick .................................................................... 19
9 stadia in het eerste uur na de geboorte ........................................................................................ 19
HC 2.1 Belang en werkingsmechanismen van voeding – A. Verhoeven ............................................... 20
, Verhoogde nutriëntbehoefte ........................................................................................................... 20
Kritische fase .................................................................................................................................... 21
Metabole veranderingen tijdens zwangerschap .............................................................................. 21
Nutriëntentransport door de placenta ............................................................................................. 22
Borstvoeding .................................................................................................................................... 23
HC 2.2 Praktische voedingsadviezen – dr. Ir. L. van Rossem ................................................................ 24
Te beperken producten .................................................................................................................... 24
Te vermijden producten ................................................................................................................... 25
Vegetariërs/veganisten .................................................................................................................... 25
Veranderde behoefte ....................................................................................................................... 25
HC 2.3 Basisprincipes gezonde voeding – M. van Kemenade ............................................................... 25
Mediterraan dieet ............................................................................................................................ 26
HC 2.4 Periconceptional and embryonic health – ................................................................................ 26
HC 2.5 Nutritional assessment – Elmi Wopereis .................................................................................. 27
HC 2.8 Roken, zwangerschap en het kind – Jasper Been ...................................................................... 28
Feiten over roken ............................................................................................................................. 28
Risico’s van roken tijdens zwangerschap .......................................................................................... 29
Risico’s van roken na geboorte ........................................................................................................ 29
Maatregelen WHO ........................................................................................................................... 29
Alcohol ............................................................................................................................................. 29
HC 2.10 Mindfulness – Rianne vd Kleij ................................................................................................. 31
HC 2.11 Zwangerschap: overgewicht, leefstijl en bariatrie – dr. S. Schoenmakers .............................. 32
HC2.11 Borstvoeding – M.J. Vermeulen ............................................................................................... 33
Voedingsmethoden .......................................................................................................................... 33
Moedermelk vs. Kunstvoeding ......................................................................................................... 33
Voordelen voor moeder ................................................................................................................... 34
HC3.1 Periconceptionele periode en embryonale gezondheid – Melek Rousian ................................. 34
PREDICT STUDY: ............................................................................................................................... 34
HC 3.2 Circadiaanse klok – Inês Chaves ................................................................................................ 35
Consequenties verstoring circadiaan ritme ...................................................................................... 36
Slaapstoornissen .............................................................................................................................. 36
Muizenstudie.................................................................................................................................... 36
HC 3.3 Inleiding IVF – Esther Baart ....................................................................................................... 37
Semenkwaliteit beoordelen ............................................................................................................. 37
Eicelrijping ........................................................................................................................................ 37
Bevruchting ...................................................................................................................................... 38
, Embryo kweek .................................................................................................................................. 38
Embryo selectie ................................................................................................................................ 38
HC3.4 VR voor biomedische visualisatie – dr. A.H.J. Koning ................................................................. 38
Echo 8-10 weken .............................................................................................................................. 38
20 weken echo ................................................................................................................................. 39
13 weken echo ................................................................................................................................. 39
HC 3.5 Cardiovasculaire gezondheid en zwangerschap – R. Bijl ........................................................... 39
Hemodynamische veranderingen tijdens de zwangerschap ............................................................ 39
Hemodynamische veranderingen tijdens de partus ......................................................................... 39
Placenta ............................................................................................................................................ 39
HC 3.6 Placenta – B. van Rijn ................................................................................................................ 40
HC 3.9 Geneesmiddelen in de zwangerschap – dr. Robert Flint ........................................................... 43
HC 3.10 Jonge zwangerschap – Lisa Lashley & A. Mulders ................................................................... 46
Miskraam ......................................................................................................................................... 48
Mola zwangerschap.......................................................................................................................... 48
Ectopische zwangerschap ................................................................................................................. 48
HC 3.11 Ovariële veroudering – dr. Y. Louwers .................................................................................... 48
HC 3.12 (Borst)kanker en zwangerschap – J. Duvekot.......................................................................... 49
HC 3.13 Genetica – Marieke Joosten .................................................................................................... 50
Genetische diagnostiek .................................................................................................................... 50
Hemofilie .......................................................................................................................................... 50
Beleid ............................................................................................................................................... 50
Myotone dystrofie/M. Steinert ........................................................................................................ 51
NIPT .................................................................................................................................................. 51
Noonan syndroom............................................................................................................................ 51
HC 3.14 Afvallen bij obesitas – G. Jiskoot ............................................................................................. 51
HC 3.15 Lifecourse medicine – prof. dr. A. Franx ................................................................................. 52
HC 4.1&4.2 Prenatale diagnostiek – Nina Peters.................................................................................. 52
Invasieve diagnostiek ....................................................................................................................... 52
Non-invasieve testen ........................................................................................................................ 53
HC4.5 Foetale therapie – Alex Eggink & Philip Dekoninck .................................................................... 53
Spina bifida ....................................................................................................................................... 54
Congenitale hernia diafragmatica (CHD) .......................................................................................... 55
Tweelingtransfusie syndroom (TTTS) ............................................................................................... 55
HC 4.6 Foetale en neonatale hersenontwikkeling – Fieke Husen ......................................................... 56
Normale hersenontwikkeling ........................................................................................................... 56
, Abnormale hersenontwikkeling ....................................................................................................... 56
HC 4.7 Foetale en neonatale hersenontwikkeling – Gerbrich v/d Bosch .............................................. 57
Vroege hersenontwikkeling .............................................................................................................. 57
Hersenstoornissen bij neonaten....................................................................................................... 57
HC 4.8 Asfyxie – R. Swarte .................................................................................................................... 58
HC 4.9 Dreigende vroeggeboorte – J. Duvekot ..................................................................................... 58
Uterus myometrium (spier) .............................................................................................................. 59
Vroeggeboorte ................................................................................................................................. 59
HC 4.10 Follow-up – R. Swarte ............................................................................................................. 59
HC 4.11 Neonatale neuroimaging – Gerbrich vd Bosch ........................................................................ 60
Echo.................................................................................................................................................. 60
HC 4.13 Ondervoeding bij kinderen – dr. K. Joosten ............................................................................ 60
HC 5.1 Anesthesie in de zwangerschap – dr. C. vd Marel ..................................................................... 61
HC 5.3a MOET – Jerome Cornette ........................................................................................................ 62
A ....................................................................................................................................................... 62
B ....................................................................................................................................................... 62
C ....................................................................................................................................................... 62
D ....................................................................................................................................................... 63
E ....................................................................................................................................................... 63
F........................................................................................................................................................ 63
HC 5.3b Newborn life support – Nanda van Paassen ........................................................................... 63
HC 5.4 Dakloze gezinnen – Liesbeth van Luijn ...................................................................................... 63
HC5.5 Hemodynamica van de neonaat – I. Reiss.................................................................................. 64
HC 6.3 ................................................................................................................................................... 64
