AGNP BOARD EXAM: Dermatology Prescription (100 Questions
with Answers and Explanations)
Question:
Systemic ivermectin (Stromectol), classified as an antiparasitic,:
is primarily excreted in the urine.
crosses the blood-brain barrier.
has a high concentration in the liver. Correct
is not well absorbed.
Explanation:
Systemic ivermectin (Stromectol) is well absorbed and is primarily excreted in the feces. It is
distributed and highly concentrated in the liver and adipose tissue. It is primarily bound to
albumin, with a half-life elimination of 18 hours. Time to peak serum is about 4 hours.
Question:
Topical permethrin (Elimite) in the treatment of scabies should be left in place for a minimum of:
30 minutes.
2 hours.
6 hours.
8 hours. Correct
Explanation:
Patients should massage permethrin cream (Elimite) thoroughly into the skin from the neck to
the soles of the feet, including areas under the fingernails and toenails. Thirty grams is usually
sufficient for an average adult. The hairline, neck, temples, and forehead may be infested in
infants and geriatric patients. In these populations, permethrin should also be applied to the scalp
and face, sparing the eyes and mouth. The cream should be removed by washing (shower or
bath) after 8 to 14 hours.
Question:
The mechanism of action of clindamycin (Cleocin), used in the treatment of cellulitis, is to:
, block synthesis of folic acid by bacteria and inhibit replication.
uncouple mitochondrial oxidative metabolism and inhibit cell growth.
block the dissociation of peptidyl tRNA from ribosomes.
inhibit protein synthesis by preventing ribosomal translocation. Correct
Explanation:
Sulfa agents block synthesis of folic acid by bacteria and thus inhibit bacterial replication. First-
generation cephalosporins inhibit cell wall synthesis of bacteria. Antifungals uncouple
mitochondrial oxidative metabolism and inhibit cell growth. Macrolides inhibit bacterial growth,
possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent
protein synthesis to arrest. Other antibacterials are bacteriostatic or bactericidal and inhibit
protein synthesis by preventing ribosomal translocation.
Question:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris and:
acne rosacea.
dermatomyositis.
inflammatory keratosis pilaris.
mottled hyperpigmentation. Correct
Explanation:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris, palliation of fine
wrinkles, mottled hyperpigmentation and facial skin roughness.
Question:
The brand name of oral isotretinoin is:
Duac.
Absorica. Correct
Accolate.
Accupril.
Explanation:
The brand names of oral isotretinoin include Absorica, Amnesteem, Claravis, and Zenatane. The
generic name for Duac is clindamycin/benzoyl peroxide, used in the treatment of acne. The
,generic name for Accolate is zafirlukast. It is a leukotriene inhibitor used in the treatment of
asthma. The generic name for Accupril is quinapril; it is an ACE inhibitor.
Question:
Benzoyl peroxide (Benzac wash) is classified as a topical:
antibiotic.
astringent.
antimicrobial. Correct
acetic acid-based cleanser.
Explanation:
Benzoyl peroxide is a topical antimicrobial used in the treatment of acne. When applied to the
skin, benzoyl peroxide works by reducing the amount of acne-causing bacteria and by causing
the skin to dry and peel.
Question:
The generic name for Elidel is:
permethrin.
pimecrolimus. Correct
tacrolimus.
urea topical.
Explanation:
The generic name for Elidel is pimecrolimus. Elidel is a dermatologic agent used in the treatment
of atopic dermatitis. The brand name of permethrin is Nix or Elimite. It is an antiparasitic used in
the treatment of lice. The brand name for tacrolimus is Prograf. It is an immunosuppressive drug
used after transplant. The brand name of urea topical is Keralac and it is used in the treatment of
hyperkeratosis.
Question:
Which of the following conditions is NOT a side effect of long-term use of topical steroids?
Cutaneous atrophy
Glaucoma
Hypotrichosis Correct
, Telangiectasia
Explanation:
Cutaneous and systemic side effects can occur, particularly with super potent and potent drugs,
or extensive use of lower potency agents with or without occlusion. Treatment with topical
corticosteroids should be restricted to the lowest and shortest duration of therapy required to
achieve the desired effect. Cutaneous atrophy, telangiectasia, hypertrichosis, striae, purpura,
hypopigmentation, glaucoma, and suppression of the hypothalamic-pituitary axis are side effects
that may occur with topical corticosteroid use.
Question:
Patients using fluorouracil (Carac) for the treatment of actinic keratosis should be advised to
expect:
hypopigmentation.
eczema.
pustular formation.
vesiculation. Correct
Explanation:
When fluorouracil (Carac) is applied to a lesion, erythema followed by vesiculation,
desquamation, erosion and re-epithelialization occurs. Local reactions and alterations in skin
appearance may persist for several weeks after discontinuation.
Question:
Tetracycline (Sumycin) is used in the treatment of skin and skin structure infections caused by:
Bartonella bacilliformis.
Klebsiella species.
Escherichia coli.
Staphylococcus aureus. Correct
Explanation:
Tetracycline (Sumycin) is indicated for the treatment of skin and skin structure infections caused
by Staphylococcus aureus or Staphylococcus pyogenes (commonly found in post burn
infections).
with Answers and Explanations)
Question:
Systemic ivermectin (Stromectol), classified as an antiparasitic,:
is primarily excreted in the urine.
crosses the blood-brain barrier.
has a high concentration in the liver. Correct
is not well absorbed.
Explanation:
Systemic ivermectin (Stromectol) is well absorbed and is primarily excreted in the feces. It is
distributed and highly concentrated in the liver and adipose tissue. It is primarily bound to
albumin, with a half-life elimination of 18 hours. Time to peak serum is about 4 hours.
Question:
Topical permethrin (Elimite) in the treatment of scabies should be left in place for a minimum of:
30 minutes.
2 hours.
6 hours.
8 hours. Correct
Explanation:
Patients should massage permethrin cream (Elimite) thoroughly into the skin from the neck to
the soles of the feet, including areas under the fingernails and toenails. Thirty grams is usually
sufficient for an average adult. The hairline, neck, temples, and forehead may be infested in
infants and geriatric patients. In these populations, permethrin should also be applied to the scalp
and face, sparing the eyes and mouth. The cream should be removed by washing (shower or
bath) after 8 to 14 hours.
Question:
The mechanism of action of clindamycin (Cleocin), used in the treatment of cellulitis, is to:
, block synthesis of folic acid by bacteria and inhibit replication.
uncouple mitochondrial oxidative metabolism and inhibit cell growth.
block the dissociation of peptidyl tRNA from ribosomes.
inhibit protein synthesis by preventing ribosomal translocation. Correct
Explanation:
Sulfa agents block synthesis of folic acid by bacteria and thus inhibit bacterial replication. First-
generation cephalosporins inhibit cell wall synthesis of bacteria. Antifungals uncouple
mitochondrial oxidative metabolism and inhibit cell growth. Macrolides inhibit bacterial growth,
possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent
protein synthesis to arrest. Other antibacterials are bacteriostatic or bactericidal and inhibit
protein synthesis by preventing ribosomal translocation.
Question:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris and:
acne rosacea.
dermatomyositis.
inflammatory keratosis pilaris.
mottled hyperpigmentation. Correct
Explanation:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris, palliation of fine
wrinkles, mottled hyperpigmentation and facial skin roughness.
Question:
The brand name of oral isotretinoin is:
Duac.
Absorica. Correct
Accolate.
Accupril.
Explanation:
The brand names of oral isotretinoin include Absorica, Amnesteem, Claravis, and Zenatane. The
generic name for Duac is clindamycin/benzoyl peroxide, used in the treatment of acne. The
,generic name for Accolate is zafirlukast. It is a leukotriene inhibitor used in the treatment of
asthma. The generic name for Accupril is quinapril; it is an ACE inhibitor.
Question:
Benzoyl peroxide (Benzac wash) is classified as a topical:
antibiotic.
astringent.
antimicrobial. Correct
acetic acid-based cleanser.
Explanation:
Benzoyl peroxide is a topical antimicrobial used in the treatment of acne. When applied to the
skin, benzoyl peroxide works by reducing the amount of acne-causing bacteria and by causing
the skin to dry and peel.
Question:
The generic name for Elidel is:
permethrin.
pimecrolimus. Correct
tacrolimus.
urea topical.
Explanation:
The generic name for Elidel is pimecrolimus. Elidel is a dermatologic agent used in the treatment
of atopic dermatitis. The brand name of permethrin is Nix or Elimite. It is an antiparasitic used in
the treatment of lice. The brand name for tacrolimus is Prograf. It is an immunosuppressive drug
used after transplant. The brand name of urea topical is Keralac and it is used in the treatment of
hyperkeratosis.
Question:
Which of the following conditions is NOT a side effect of long-term use of topical steroids?
Cutaneous atrophy
Glaucoma
Hypotrichosis Correct
, Telangiectasia
Explanation:
Cutaneous and systemic side effects can occur, particularly with super potent and potent drugs,
or extensive use of lower potency agents with or without occlusion. Treatment with topical
corticosteroids should be restricted to the lowest and shortest duration of therapy required to
achieve the desired effect. Cutaneous atrophy, telangiectasia, hypertrichosis, striae, purpura,
hypopigmentation, glaucoma, and suppression of the hypothalamic-pituitary axis are side effects
that may occur with topical corticosteroid use.
Question:
Patients using fluorouracil (Carac) for the treatment of actinic keratosis should be advised to
expect:
hypopigmentation.
eczema.
pustular formation.
vesiculation. Correct
Explanation:
When fluorouracil (Carac) is applied to a lesion, erythema followed by vesiculation,
desquamation, erosion and re-epithelialization occurs. Local reactions and alterations in skin
appearance may persist for several weeks after discontinuation.
Question:
Tetracycline (Sumycin) is used in the treatment of skin and skin structure infections caused by:
Bartonella bacilliformis.
Klebsiella species.
Escherichia coli.
Staphylococcus aureus. Correct
Explanation:
Tetracycline (Sumycin) is indicated for the treatment of skin and skin structure infections caused
by Staphylococcus aureus or Staphylococcus pyogenes (commonly found in post burn
infections).
