CORONA VIRUS
, Coronaviruses
(CoVs) are a major group of viruses known to be responsible for wide
spectrum of diseases in multiple species. The CoVs affecting human
population are referred to as human coronaviruses (HCoVs). They
lead to multiple respiratory diseases, such as common cold,
pneumonia, bronchitis, severe acute respiratory syndrome, and
Middle East respiratory syndrome. CoVs are RNA viruses that require
RNA-dependent RNA polymerases (RdRPs) for various steps in their
life cycle.
Action of RdRP is needed in several steps in the life cycle of CoVs and
thus RdRPs constitute potential targets for drugs and other
therapeutic interventions for the treatment of diseases caused by
CoVs. The chapter therefore presents a detailed discussion on the
structure and functions of CoV polymerases and the development of
their potential inhibitors.
, Coronaviruses
(CoVs) are a major group of viruses known to be responsible for wide
spectrum of diseases in multiple species. The CoVs affecting human
population are referred to as human coronaviruses (HCoVs). They
lead to multiple respiratory diseases, such as common cold,
pneumonia, bronchitis, severe acute respiratory syndrome, and
Middle East respiratory syndrome. CoVs are RNA viruses that require
RNA-dependent RNA polymerases (RdRPs) for various steps in their
life cycle.
Action of RdRP is needed in several steps in the life cycle of CoVs and
thus RdRPs constitute potential targets for drugs and other
therapeutic interventions for the treatment of diseases caused by
CoVs. The chapter therefore presents a detailed discussion on the
structure and functions of CoV polymerases and the development of
their potential inhibitors.
