to accompany
Psychopharmacology, Third Edition
Meyer • Quenzer
Chapter 4: Methods of Research in Psychopharmacology
Multiple Choice
1. Which statement about methods of research in neurobehavioral pharmacology is false?
a. Use of scientific method and critical reading of literature are necessary skills.
b. Methods focus only on the molecular level, not the whole organism.
c. Researchers must be able to quantify changes in behavior, mood, and thinking.
d. Many studies require images of neurotransmitters and receptors in the living brain.
Answer: b
Textbook Reference: Research Methods for Evaluating the Brain and Behavior
2. Which statement about the importance of behavioral measures in psychopharmacology
is false?
a. Behavioral measures use observational measures, which are the most reliable and
valid approaches.
b. Behavioral measures are used for developing animal models of psychiatric disorders.
c. Behavioral measures are used for screening newly-developed drug molecules in
preclinical trials.
d. Behavioral measures aid in understanding the neurochemical basis of behavior.
Answer: a
Textbook Reference: Evaluating Animal Behavior
3. Which of the following is not an advantage of animal studies in psychopharmacology?
a. They allow for precise control of living conditions not possible with humans.
b. Assessing emotional and psychological changes in response to
experimental manipulations is relatively straightforward in nonhuman
subjects.
c. The past histories of animal subjects are known to the investigator.
d. Invasive procedures that would be unethical on humans can be used.
Answer: b
Textbook Reference: Evaluating Animal Behavior
4. What are the limitations to studying fetal alcohol syndrome (FAS) in human subjects?
a. There are not enough cases to study.
b. The studies are correlational only; one cannot assert that alcohol causes any particular
effect.
c. There is very little evidence for FAS in children born to women in the United States.
d. It is impossible to obtain permission to conduct this type of research.
Answer: b
Textbook Reference: Evaluating Animal Behavior
, 5. Which of the following is not a guideline of the Health Extension Act of 1985?
a. Researchers should be trained in basic veterinary care.
b. Alternative methods, such as computer simulation, should be considered.
c. Procedures must avoid or minimize distress or pain.
d. Research must benefit society or advance knowledge.
Answer: a
Textbook Reference: Evaluating Animal Behavior
6. Good behavioral tests for drug effects should meet a variety of criteria. Which of
the following is not one of these criteria?
a. They should be specific for the drug class being screened.
b. They should have face validity.
c. They should be reliable.
d. They should be sensitive, and show the same rank order of potency as seen
in therapeutic action.
Answer: b
Textbook Reference: Evaluating Animal Behavior
7. The is a test of analgesia.
a. open field test
b. catalepsy test
c. tail-flick test
d. multiple T-maze
Answer: c
Textbook Reference: Evaluating Animal Behavior
8. Which of the following is not a test for learning and memory?
a. Morris water maze
b. T-maze
c. Light–dark crossing task
d. Delayed-response test
Answer: c
Textbook Reference: Evaluating Animal Behavior
9. Which pair of behavioral test and what it is designed to measure is incorrectly
matched?
a. Delayed-response test: fear
b. Conditioned place preference: reward
c. Elevated plus-maze: anxiety
d. Conditioned emotional response: fear
Answer: a
Textbook Reference: Evaluating Animal Behavior
10. Animals will not self-administer
a. cocaine.