IMMUNOLOGY AND SEROLOGY SAMPLEX
12. Where do lymphocytes mainly come in contact with
1. Which of the following can be attributed to Pasteur? antigens?
A. Discovery of opsonins A. Secondary lymphoid organs
B. Observation of phagocytosis B. Bloodstream
C. First attenuated vaccines C. Bone marrow
D. Theory of humoral immunity D. Thymus
2. Which RBC is capable of further differentiation in tissues? 13. Which of the following is found on the T cell subset known as
A. Neutrophil helpers?
B. Eosinophil A. CD19
C. Basophil B. CD4
D. Monocyte C. CD8
D. CD56
3. The cells what Metchnikoff first observed are associated with
which phenomenon? 14. Which of the following statements best characterizes
A. Innate immunity adaptive immunity?
B. Adaptive immunity A. Relies on normally present body functions
C. Humoral immunity B. Response is similar for each exposure
D. Specific immunity C. Specificity for each individual pathogen
D. Involves only cellular immunity
4. Where are all undifferentiated lymphocytes made?
A. Bone marrow 15. The main function of T cells in the immune response is to
B. Spleen A. Produce cytokines that regulate both innate and
C. Thymus adaptive immunity
D. Lymph nodes B. Produce antibodies
C. Participate actively in phagocytosis
5. Which of the following statements is true of NK cells? D. Respond to target cells without prior exposure
A. They rely upon memory for antigen recognition
B. They have the same CD groups as B cells 16. Which of the following is a part of humoral immunity?
C. They are found manly in lymph nodes A. Cells involved in phagocytosis
D. They kill target cells without prior exposure to them B. Neutralization of toxins by serum
C. Macrophages and mast cells in the tissue
6. Which cell is the most potent phagocytic cell in the tissue? D. T and B cells in lymph nodes
A. Neutrophil
B. Dendritic cell 17. Immunity can be defined as
C. Eosinophil A. The study of medicines used to treat diseases
D. Basophil B. A specific population at risk for a disease
C. The condition of being resistant to disease
7. The ability of an individual to resist infection by means of D. The study of the noncellular portion of the blood
normally present body functions is called
A. Innate immunity 18. A blood cell that has reddish staining granules and is able tokill
B. Humoral immunity large parasites describes
C. Adaptive immunity A. Basophils
D. Cross-immunity B. Monocytes
C. Neutrophils
8. A cell characterized by a nucleus with two to five lobes, a D. Eosinophils
diameter of 10 to 15 micrometer, and a large number of
neutral staining granules is identified as a (n) 19. Which of the following statements best describes a lymph
A. Eosinophil node?
B. Monocyte A. It is considered a primary lymphoid organ
C. Basophil B. It removes old RBCs
D. Neutrophil C. It collects fluid from the tissues
D. It is where B cells mature
9. Which of the following is a primary lymphoid organ?
A. Lymph node 20. Antigenic groups identified by different sets of antibodies
B. Spleen reacting in a similar manner to certain standard cell lines best
C. Thymus describes
D. MALT A. Cytokines
B. Clusters of differentiation (CD)
10. What type of cells would be found in a primary follicle? C. Neutrophilic granules
A. Unstimulated B cells D. Opsonins
B. Germinal centers
C. Plasma cells 21. The term for enhancement of phagocytosis by coating of
D. Memory cells foreign particles with serum proteins is
A. Opsonization
11. Which of the following is distinguishing feature of B cells? B. Agglutination
A. Act as helper cells C. Solubilization
B. Presence of surface antibody D. Chemotaxis
C. Able to kill target cells without prior exposure
D. Active in phagocytosis
, 22. Which of the following plays an important role as an external
defense mechanism? 32. Which statement best describes Toll-like receptors (TLRs)
A. Phagocytosis A. They protect adult flies from infection
B. C-reactive protein B. They are found on all host cells
C. Lysozyme C. They only play a role in adaptive immunity
D. Complement D. They enhance phagocytosis
23. The process of inflammation is characterized by all of the 33. The action of CRP can be distinguished from that of an
following except: antibody because
A. Increased blood supply to the area A. CRP acts before the antibody appears
B. Migration of WBCs B. Only the antibody triggers the complement cascade
C. Decreased capillary permeability C. Binding of the antibody is calcium-dependent
D. Appearance of acute-phase reactants D. Only CRP acts as an opsonin
24. Skin, lactic acid secretions, stomach acidity, and the motionof 34. How does innate immunity differ from adaptive immunity?
cilia represent which type of immunity? A. Innate immunity requires prior exposure to a pathogen
A. Innate B. Innate immunity depends upon normally present body
B. Cross functions
C. Adaptive C. Innate immunity develops later than adaptive immunity
D. Auto D. Innate immunity is more specific than adaptive
immunity
25. The structure formed by the fusion of engulfed material and
enzymatic granules within the phagocytic cell is called a 35. A 40-year-old male who is a smoker develops symptoms of
A. Phagosome premature emphysema. The symptoms may be caused by a
B. Lysosome deficiency of which of the following acute-phase reactants?
C. Vacuole A. Haptoglobin
D. Phagolysosome B. Alpha 1 – antitrypsin
C. Fibrinogen
26. The presence of human microbiota (normal flora) acts as a D. Ceruloplasmin
defense mechanism by which of the following methods?
A. Maintaining an acid environment 36. Which statement best describes NK cells?
B. Competing with potential pathogens A. Their response against pathogens is very specific
C. Keeping phagocytes in the area B. They only react when an abundance of MHC antigensis
D. Coating mucosal surfaces present
C. They react when both an inhibitory and activating signalis
27. Measurement of CRP levels can be used for all of the triggered
following except: D. They are able to kill target cells without previous
A. Monitoring drug therapy with anti-inflammatory agents exposure to them
B. Tracking the progress of an organ transplant
C. Diagnosis of a specific bacterial infection 37. Which MHC molecule is necessary for antigen recognition by
D. Determining active phases of rheumatoid arthritis CD4+ T cells?
A. Class I
28. Pathogen recognition receptors act by B. Class II
A. Recognizing molecules common to both host cells and C. Class III
pathogens D. No MHC molecule is necessary
B. Recognizing molecules that are unique to pathogens
C. Helping to spread infection because they are found on 38. Which would be characteristic of a T-independent antigen?
pathogens A. The IgG antibody is produced exclusively
D. All recognizing the same pathogens B. A large number of memory cell are produced
C. Antigens bind only one receptor on B cells
29. Which of the following are characteristics of acute-phase D. It consists of a limited number of repeating
reactants? determinants
A. Rapid increases following infection
B. Enhancement of phagocytosis 39. Humoral immunity refers to which of the following?
C. Nonspecific indicators of inflammation A. Production of antibody by plasma cells
D. All of the above B. Production of cytokines by T cells
C. Eliminations of virally infected cells by cytotoxic cells
30. Which is the most significant agent formed in the D. Downregulation of the immune response
phagolysosome for the elimination of microorganisms?
A. Proteolytic enzymes 40. Where does antigen-independent maturation of B
B. Hydrogen ions lymphocytes take place?
C. Hypochlorite ions A. Bone marrow
D. Superoxides B. Thymus
C. Spleen
31. Which acute-phase reactant helps to prevent formation of D. Lymph nodes
peroxides and free radicals that may damage tissues?
A. Haptoglobin 41. In the thymus, positive selection of immature T cells is basedupon
B. Fibrinogen recognition of which of the following?
C. Ceruloplasmin A. Self-antigens
D. Serum Amyloid A B. Stress proteins
12. Where do lymphocytes mainly come in contact with
1. Which of the following can be attributed to Pasteur? antigens?
A. Discovery of opsonins A. Secondary lymphoid organs
B. Observation of phagocytosis B. Bloodstream
C. First attenuated vaccines C. Bone marrow
D. Theory of humoral immunity D. Thymus
2. Which RBC is capable of further differentiation in tissues? 13. Which of the following is found on the T cell subset known as
A. Neutrophil helpers?
B. Eosinophil A. CD19
C. Basophil B. CD4
D. Monocyte C. CD8
D. CD56
3. The cells what Metchnikoff first observed are associated with
which phenomenon? 14. Which of the following statements best characterizes
A. Innate immunity adaptive immunity?
B. Adaptive immunity A. Relies on normally present body functions
C. Humoral immunity B. Response is similar for each exposure
D. Specific immunity C. Specificity for each individual pathogen
D. Involves only cellular immunity
4. Where are all undifferentiated lymphocytes made?
A. Bone marrow 15. The main function of T cells in the immune response is to
B. Spleen A. Produce cytokines that regulate both innate and
C. Thymus adaptive immunity
D. Lymph nodes B. Produce antibodies
C. Participate actively in phagocytosis
5. Which of the following statements is true of NK cells? D. Respond to target cells without prior exposure
A. They rely upon memory for antigen recognition
B. They have the same CD groups as B cells 16. Which of the following is a part of humoral immunity?
C. They are found manly in lymph nodes A. Cells involved in phagocytosis
D. They kill target cells without prior exposure to them B. Neutralization of toxins by serum
C. Macrophages and mast cells in the tissue
6. Which cell is the most potent phagocytic cell in the tissue? D. T and B cells in lymph nodes
A. Neutrophil
B. Dendritic cell 17. Immunity can be defined as
C. Eosinophil A. The study of medicines used to treat diseases
D. Basophil B. A specific population at risk for a disease
C. The condition of being resistant to disease
7. The ability of an individual to resist infection by means of D. The study of the noncellular portion of the blood
normally present body functions is called
A. Innate immunity 18. A blood cell that has reddish staining granules and is able tokill
B. Humoral immunity large parasites describes
C. Adaptive immunity A. Basophils
D. Cross-immunity B. Monocytes
C. Neutrophils
8. A cell characterized by a nucleus with two to five lobes, a D. Eosinophils
diameter of 10 to 15 micrometer, and a large number of
neutral staining granules is identified as a (n) 19. Which of the following statements best describes a lymph
A. Eosinophil node?
B. Monocyte A. It is considered a primary lymphoid organ
C. Basophil B. It removes old RBCs
D. Neutrophil C. It collects fluid from the tissues
D. It is where B cells mature
9. Which of the following is a primary lymphoid organ?
A. Lymph node 20. Antigenic groups identified by different sets of antibodies
B. Spleen reacting in a similar manner to certain standard cell lines best
C. Thymus describes
D. MALT A. Cytokines
B. Clusters of differentiation (CD)
10. What type of cells would be found in a primary follicle? C. Neutrophilic granules
A. Unstimulated B cells D. Opsonins
B. Germinal centers
C. Plasma cells 21. The term for enhancement of phagocytosis by coating of
D. Memory cells foreign particles with serum proteins is
A. Opsonization
11. Which of the following is distinguishing feature of B cells? B. Agglutination
A. Act as helper cells C. Solubilization
B. Presence of surface antibody D. Chemotaxis
C. Able to kill target cells without prior exposure
D. Active in phagocytosis
, 22. Which of the following plays an important role as an external
defense mechanism? 32. Which statement best describes Toll-like receptors (TLRs)
A. Phagocytosis A. They protect adult flies from infection
B. C-reactive protein B. They are found on all host cells
C. Lysozyme C. They only play a role in adaptive immunity
D. Complement D. They enhance phagocytosis
23. The process of inflammation is characterized by all of the 33. The action of CRP can be distinguished from that of an
following except: antibody because
A. Increased blood supply to the area A. CRP acts before the antibody appears
B. Migration of WBCs B. Only the antibody triggers the complement cascade
C. Decreased capillary permeability C. Binding of the antibody is calcium-dependent
D. Appearance of acute-phase reactants D. Only CRP acts as an opsonin
24. Skin, lactic acid secretions, stomach acidity, and the motionof 34. How does innate immunity differ from adaptive immunity?
cilia represent which type of immunity? A. Innate immunity requires prior exposure to a pathogen
A. Innate B. Innate immunity depends upon normally present body
B. Cross functions
C. Adaptive C. Innate immunity develops later than adaptive immunity
D. Auto D. Innate immunity is more specific than adaptive
immunity
25. The structure formed by the fusion of engulfed material and
enzymatic granules within the phagocytic cell is called a 35. A 40-year-old male who is a smoker develops symptoms of
A. Phagosome premature emphysema. The symptoms may be caused by a
B. Lysosome deficiency of which of the following acute-phase reactants?
C. Vacuole A. Haptoglobin
D. Phagolysosome B. Alpha 1 – antitrypsin
C. Fibrinogen
26. The presence of human microbiota (normal flora) acts as a D. Ceruloplasmin
defense mechanism by which of the following methods?
A. Maintaining an acid environment 36. Which statement best describes NK cells?
B. Competing with potential pathogens A. Their response against pathogens is very specific
C. Keeping phagocytes in the area B. They only react when an abundance of MHC antigensis
D. Coating mucosal surfaces present
C. They react when both an inhibitory and activating signalis
27. Measurement of CRP levels can be used for all of the triggered
following except: D. They are able to kill target cells without previous
A. Monitoring drug therapy with anti-inflammatory agents exposure to them
B. Tracking the progress of an organ transplant
C. Diagnosis of a specific bacterial infection 37. Which MHC molecule is necessary for antigen recognition by
D. Determining active phases of rheumatoid arthritis CD4+ T cells?
A. Class I
28. Pathogen recognition receptors act by B. Class II
A. Recognizing molecules common to both host cells and C. Class III
pathogens D. No MHC molecule is necessary
B. Recognizing molecules that are unique to pathogens
C. Helping to spread infection because they are found on 38. Which would be characteristic of a T-independent antigen?
pathogens A. The IgG antibody is produced exclusively
D. All recognizing the same pathogens B. A large number of memory cell are produced
C. Antigens bind only one receptor on B cells
29. Which of the following are characteristics of acute-phase D. It consists of a limited number of repeating
reactants? determinants
A. Rapid increases following infection
B. Enhancement of phagocytosis 39. Humoral immunity refers to which of the following?
C. Nonspecific indicators of inflammation A. Production of antibody by plasma cells
D. All of the above B. Production of cytokines by T cells
C. Eliminations of virally infected cells by cytotoxic cells
30. Which is the most significant agent formed in the D. Downregulation of the immune response
phagolysosome for the elimination of microorganisms?
A. Proteolytic enzymes 40. Where does antigen-independent maturation of B
B. Hydrogen ions lymphocytes take place?
C. Hypochlorite ions A. Bone marrow
D. Superoxides B. Thymus
C. Spleen
31. Which acute-phase reactant helps to prevent formation of D. Lymph nodes
peroxides and free radicals that may damage tissues?
A. Haptoglobin 41. In the thymus, positive selection of immature T cells is basedupon
B. Fibrinogen recognition of which of the following?
C. Ceruloplasmin A. Self-antigens
D. Serum Amyloid A B. Stress proteins
