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ENZYMES Biochemistry Biotechnology and Clinical Chemistry

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ENZYMES Biochemistry Biotechnology and Clinical Chemistry Second Edition .Senior Lecturer in Biochemistry Trevor Palmer, BA, PhD, CBiol, FIBiol, FIBMS, FHEA Nottingham Trent University. 1 An introduction to enzymes/ 2 The structure of proteins/ 3 The biosynthesis and properties of proteins/ 4 Specificity of enzyme action/ 5 Monomeric and oligomeric enzymes/ 6 An introduction to bioenergetics, catalysis and kinetics

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,ENZYMES:
Biochemistry, Biotechnology and Clinical Chemistry
Second Edition




"Talking of education, people have now a-days" (said he) "got a
strange opinion that every thing should be taught by lectures. Now, I
cannot see that lectures can do so much good as reading the books
from which the lectures are taken. I know nothing that can be best
taught by lectures, except where experiments are to be shewn. You
may teach chymestry by lectures - You might teach making of shoes
by lectures!"
James Boswell: Life ofSamuel Johnson, 1766

, ABOUT THE AUTHORS
Trevor Palmer was born in South Yorkshire and graduated from Cambridge
University in 1966 with an honours degree in biochemistry, being influenced
by (amongst others) Peter Sykes in organic chemistry and Malcolm Dixon in
enzymology. He then worked as a clinical biochemist at the Queen Elizabeth
Hospital for Children, linked to the Institute of Child Health, University of
London, obtaining a PhD for research into inherited disorders. From this
emerged the two main interests of his subsequent career, enzymology and
evolution, the latter stimulating a further interest in the long-term effects of
natural catastrophes. He moved to Nottingham Trent University (then Trent
Polytechnic) in 1974, initially as a lecturer in biochemistry, before becoming
Head of Department of Life Sciences (1987), Dean of the Faculty of Science
and Mathematics (1992), Senior Dean of the University (1998) and Pro
Vice-Chancellor for Academic Development (2002), returning to
predominantly academic activity as Emeritus Professor in 2006. His books
include Understanding Enzymes (1981), Principles of Enzymology for
Technological Applications (1993), Controversy - Catastrophism and
Evolution (1999) and Perilous Planet Earth (2003). His wife, Jan, teaches
psychology and sociology (and is currently a part-time PhD student at
Leicester University). Their son, James, is carrying out postdoctoral studies
as a Leverhulme Fellow at Nottingham University and their daughter,
Caroline, is researching for a PhD at Sheffield University.

Philip L. Bonner went to school in Coventry, West Midlands, before
graduating from the University of Sussex in 1978 with an honours degree in
biochemistry. He then worked as a research assistant at Glaxo plc on
Merseyside before leaving to take up a Research Assistant/Demonstrator
post at Trent Polytechnic, where he obtained a PhD for research concerning
enzymes associated with seed germination. Several postdoctoral
appointments followed, at Bristol, Lancaster and Central Lancashire
Universities, working on a variety of topics including relaxin, aspartate
kinase and phospholipase C, before he was appointed as Senior Lecturer at
Nottingham Trent University in 1991. There, he has maintained his research
interests in enzymology and analytical biochemistry, working on the role of
transglutaminase in plant/animal tissue and methods to isolate and
characterise post-translationally-modified MHC peptides. His first single-
author book, on protein purification, was published in 2007. His wife, Liz, is
a manager of an occupational therapist team in Nottingham and their
daughter, Francesca, is at junior school.

, ENZYMES:
Biochemistry, Biotechnology and Clinical Chemistry
Second Edition




Trevor Palmer, BA, PhD, CBiol, FIBiol, FIBMS, FHEA
Emeritus Professor in Life Sciences
Nottingham Trent University



Philip L. Bonner, BSc, PhD
Senior Lecturer in Biochemistry
Nottingham Trent University




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