NURS 3365 CONCEPT MAP

NURS 3365 CONCEPT MAP • How well they block JUST 1 in the heart • Non-selective affect beta 1 & 2. • Can be lost at higher doses • Lipid soluble eliminated by liver • Water soluble eliminated by kidneys • CNS side effects worse in lipid soluble • Metabolized by P450 enzyme caused CYP3A4, drugs & grapefruit juice inhibit CYP3A4 • Inhibits first pass affect & increases bioavailability • Verapamil & Diltiazem have moderate CYP2A4 inhibition Metabolism Afterload – resistance to pump blood out. Related to total peripheral vascular resistance Pain radiates to the arm, neck jaw, shoulder & back Due to lack of blood supply going to systemic circulation