College 1 Pathogens: Lines of defense against pathogens: B & T cells
Immuunsysteem: - virus 1. barriers (mucosal tissue) - unique receptor (clones) - BCR & TCR
- innate (+ - bacterium - skin, lungs, intestines - unique receptor expression (clonal selection)
complement - fungus 2. innate made in thymus & bone marrow
system) - parasite - inflammation, phagocytosis - expansion (clonal expansion)
- adaptive } extra or intracellulair 3. adaptive immune system
w w
- antibodies, lymphocytes } Lymphocytes (naive B and T cells) recirculate
No memory - memory
Antigen + epitope between secondary lymphoid organs (lymph
Cells of the immuun system: fluid) and blood to find antigen
L
Depends on lymphoid organs
- Lymphoid cells (Adaptive - NK cell) - primary generation
- Myeloid cells (Innate + NK-cell) - secondary activation —> B and T cells go to different areas in lymph
- Granulocytes (leukocytes = witte bloedcel) nodes
- neutrophil (killing extracellulair bacteria) B humoral response
L
—> migration into tissue
- eosinophil intact Ag
- basophil —> antibodies
- macrofagen } phagocytosis + synthese cytokines Dendritic cells form the link between innate and T cellular response
- cytokines (cell division) + chemokines (migration) adaptive immune system! processed Ag
—> CD8 T & CD4 T
Complement system:
- classical pathway 3 IgM antibodies + CRP Neutrophils:
Antibodies:
- lectin pathway 2 mannose binding (MBL) - made in bone marrow
1. neutralization
- alternative pathway 1 Spontaneous activation - most prominent in body
2. opsonaztion
- signaled by chemokines
} C3 (= meeting point) —> C3b (complement fixation: lysis) —> short life
C3a (anaphylatoxins: attract) (degraded by macrofagen) BCR:
- Y-shaped
1. C3a —> Inflammation —> phagocytosis - two identical binding sites
2. Opsonization via C3b: phagocytosis - membrane bound + secreted form
3. membranen attack complex leads membrane lesions: lysis TCR:
—> death of pathogen - one binding site
- only membrane bound
Inflammation causes acute phase response:
- not an immunoglobulin
IL-6 —> liver } synthesis of CRP and MBL
: acts as opsonin + complement activator
Immuunsysteem: - virus 1. barriers (mucosal tissue) - unique receptor (clones) - BCR & TCR
- innate (+ - bacterium - skin, lungs, intestines - unique receptor expression (clonal selection)
complement - fungus 2. innate made in thymus & bone marrow
system) - parasite - inflammation, phagocytosis - expansion (clonal expansion)
- adaptive } extra or intracellulair 3. adaptive immune system
w w
- antibodies, lymphocytes } Lymphocytes (naive B and T cells) recirculate
No memory - memory
Antigen + epitope between secondary lymphoid organs (lymph
Cells of the immuun system: fluid) and blood to find antigen
L
Depends on lymphoid organs
- Lymphoid cells (Adaptive - NK cell) - primary generation
- Myeloid cells (Innate + NK-cell) - secondary activation —> B and T cells go to different areas in lymph
- Granulocytes (leukocytes = witte bloedcel) nodes
- neutrophil (killing extracellulair bacteria) B humoral response
L
—> migration into tissue
- eosinophil intact Ag
- basophil —> antibodies
- macrofagen } phagocytosis + synthese cytokines Dendritic cells form the link between innate and T cellular response
- cytokines (cell division) + chemokines (migration) adaptive immune system! processed Ag
—> CD8 T & CD4 T
Complement system:
- classical pathway 3 IgM antibodies + CRP Neutrophils:
Antibodies:
- lectin pathway 2 mannose binding (MBL) - made in bone marrow
1. neutralization
- alternative pathway 1 Spontaneous activation - most prominent in body
2. opsonaztion
- signaled by chemokines
} C3 (= meeting point) —> C3b (complement fixation: lysis) —> short life
C3a (anaphylatoxins: attract) (degraded by macrofagen) BCR:
- Y-shaped
1. C3a —> Inflammation —> phagocytosis - two identical binding sites
2. Opsonization via C3b: phagocytosis - membrane bound + secreted form
3. membranen attack complex leads membrane lesions: lysis TCR:
—> death of pathogen - one binding site
- only membrane bound
Inflammation causes acute phase response:
- not an immunoglobulin
IL-6 —> liver } synthesis of CRP and MBL
: acts as opsonin + complement activator
