BIOCHEM C785 Readiness Test (Answered) 2022/2023
Following transcription, what would be the resulting mRNA sequence
from this template strand: 5’-ACA GCT GTC-3’?
5' - ACA GCT GTC - 3'
5' - UGU CGA CAG - 3'
5' - GAC AGC UGU - 3'
5' - ACA GCU GUC - 3'
2
If the coding (non-template) DNA sequence of a normal gene is 5' GTC GCA TGG TGA 3',
which DNA sequence would represent a silent mutation?
5' ATC GCA TGG TGA 3'
5' GTC GCA TAG TGA 3'
5' GTC GCG TGG TGA 3'
None of the above.
3
A patient with xeroderma pigmentosum is prone to developing multiple skin cancers
starting in childhood. This occurs because of a mutation in a gene that codes for
enzymes that help repair DNA damage through the nucleotide excision repair (NER)
pathways. How does NER differ from other repair mechanisms? During NER:
Only one nucleotide is removed and DNA polymerase replaces the one abnormality
The error in one strand of DNA is removed as well as several nucleotides on either
side of the error. The gap that was removed is filled in by DNA polymerase
The entire homologous chromosome is used to repair the double stranded DNA error
The affected DNA strand and its complementary strand is discarded and a new
double stranded DNA is created
4
Select answer A this was a pedigree question
Sex-linked dominant
Autosomal Recessive
Sex-linked recessive
mitochondrial
5
The LCT gene codes for lactase, which is responsible for the breakdown of lactose.
Which of the following statements could explain how lactase activity is increased in the
presence of lactose?
Lactose blocks RNA polymerase from binding the promoter sequence, facilitating
transcription of the LCT gene.
This study source was downloaded by 100000851646087 from CourseHero.com on 11-28-2022 04:55:24 GMT -06:00
https://www.coursehero.com/file/67645680/Readiness-test-and-answersdocx/
, Lactose prevents binding of transcription factors at the transcription start site of the
LCT gene.
The presence of lactose causes nucleosomes to separate, exposing the LCT gene.
The presence of lactose causes nucleosomes to pack together tightly, exposing
the
LCT gene.
6
Assuming there is one copy of the target DNA sequence before PCR, how many copies of
DNA are there after 5 PCR cycles?
256
65,536
32
64
7
Interaction between the two amino acids shown below can help stabilize the structure
of a protein. In which interaction would these two amino acids participate?
Ionic bond
Hydrogen bond
Disulfide bond
Hydrophobic interaction
8
Which of the following statements about the different levels of protein structure is
true?
Two or more polypeptides each with their own secondary structures come together
to form a single larger tertiary structure of a protein
Peptide bonds between amino acids make up the secondary structure of a protein
The interactions between the side chains of the amino acids make up the secondary
level structure of a protein
The interactions between the side chains of the amino acids make up the tertiary
level structure of a protein
9
Aggregation of proteins is the primary cause of many neurodegenerative diseases.
Which of the following mutations is most likely to cause a neurodegenerative disease?
Replacing a positively charged amino acid with a negatively charged amino acid
Replacing a polar amino acid with a non polar amino acid
Replacing a polar amino acid with another polar amino acid
This study source was downloaded by 100000851646087 from CourseHero.com on 11-28-2022 04:55:24 GMT -06:00
https://www.coursehero.com/file/67645680/Readiness-test-and-answersdocx/
Following transcription, what would be the resulting mRNA sequence
from this template strand: 5’-ACA GCT GTC-3’?
5' - ACA GCT GTC - 3'
5' - UGU CGA CAG - 3'
5' - GAC AGC UGU - 3'
5' - ACA GCU GUC - 3'
2
If the coding (non-template) DNA sequence of a normal gene is 5' GTC GCA TGG TGA 3',
which DNA sequence would represent a silent mutation?
5' ATC GCA TGG TGA 3'
5' GTC GCA TAG TGA 3'
5' GTC GCG TGG TGA 3'
None of the above.
3
A patient with xeroderma pigmentosum is prone to developing multiple skin cancers
starting in childhood. This occurs because of a mutation in a gene that codes for
enzymes that help repair DNA damage through the nucleotide excision repair (NER)
pathways. How does NER differ from other repair mechanisms? During NER:
Only one nucleotide is removed and DNA polymerase replaces the one abnormality
The error in one strand of DNA is removed as well as several nucleotides on either
side of the error. The gap that was removed is filled in by DNA polymerase
The entire homologous chromosome is used to repair the double stranded DNA error
The affected DNA strand and its complementary strand is discarded and a new
double stranded DNA is created
4
Select answer A this was a pedigree question
Sex-linked dominant
Autosomal Recessive
Sex-linked recessive
mitochondrial
5
The LCT gene codes for lactase, which is responsible for the breakdown of lactose.
Which of the following statements could explain how lactase activity is increased in the
presence of lactose?
Lactose blocks RNA polymerase from binding the promoter sequence, facilitating
transcription of the LCT gene.
This study source was downloaded by 100000851646087 from CourseHero.com on 11-28-2022 04:55:24 GMT -06:00
https://www.coursehero.com/file/67645680/Readiness-test-and-answersdocx/
, Lactose prevents binding of transcription factors at the transcription start site of the
LCT gene.
The presence of lactose causes nucleosomes to separate, exposing the LCT gene.
The presence of lactose causes nucleosomes to pack together tightly, exposing
the
LCT gene.
6
Assuming there is one copy of the target DNA sequence before PCR, how many copies of
DNA are there after 5 PCR cycles?
256
65,536
32
64
7
Interaction between the two amino acids shown below can help stabilize the structure
of a protein. In which interaction would these two amino acids participate?
Ionic bond
Hydrogen bond
Disulfide bond
Hydrophobic interaction
8
Which of the following statements about the different levels of protein structure is
true?
Two or more polypeptides each with their own secondary structures come together
to form a single larger tertiary structure of a protein
Peptide bonds between amino acids make up the secondary structure of a protein
The interactions between the side chains of the amino acids make up the secondary
level structure of a protein
The interactions between the side chains of the amino acids make up the tertiary
level structure of a protein
9
Aggregation of proteins is the primary cause of many neurodegenerative diseases.
Which of the following mutations is most likely to cause a neurodegenerative disease?
Replacing a positively charged amino acid with a negatively charged amino acid
Replacing a polar amino acid with a non polar amino acid
Replacing a polar amino acid with another polar amino acid
This study source was downloaded by 100000851646087 from CourseHero.com on 11-28-2022 04:55:24 GMT -06:00
https://www.coursehero.com/file/67645680/Readiness-test-and-answersdocx/
