Hypersensitivity & autoimmune diseases
1- A patient develops hemolytic anaemia which is thought to be due to long term penicillin treatment which
is the correct type of hypersensitivity reactions:
a. Type I
b. Type II
c. Type III
d. Type IV
2- Type IV hypersensitivity response:
a. Are mediated by Ag-Ab complex
b. Occur within few hours after Ag contact
c. Occur in contact dermatitis
d. Occur in hay fever
3- 14 years old girl complains that every time she wears her new metal watch, the area of skin in contact with
the watch reveals: redness, edema, itchy vesicles within 12-24 hrs. This condition is mediated by:
a. Complement
b. IgE
c. IgM
d. Natural killer
e. T lymphocytes & MQs
4- You are performing a test on a fetus in its 7th month of gestation for possibility of erythroblastosis fetalis.
What ingredients would be necessary to perform this procedure: يشرح مع العملي
a. RBCs of fetus + Coomb's reagent
b. RBCs of fetus + mother's serum
c. Serum of fetus + RBCs of mother
d. Serum of baby + Coomb's reagent
5- Which is involved in post-streptococcal GN pathogenesis:
a. Ag-Ab complex , neutrophils & complement
b. Sensitized Th cells to glomerular basement membrane
c. Cytotoxic T cells reacting with glomerular basement membrane
d. IgE mediating eosinophil degranulation
6- 10 year old boy receives monthly injection of penicillin for management of rheumatic fever. This month
immediately within minutes of injection he develops difficulity in breathing, elevated itchy rash allover ! body,
vascular collapse, how can you explain this?
a. Arthus
b. Atopy
c. Cytotoxic hypersensitivity
d. Systemic anaphylaxis
e. Serum sickness
7- Serum sickness is mediated by:
a. Cytotoxic T cells
b. IgM , IgG & complement
c. Th cells
d. MQs
1 2 3 4 5 6 7
b c e a a d b
, 8- In tuberculin test, Induration & erythema reaction has a nodule filled with:
a. Mast cells
b. Oesinophils
c. Lymphocytes & MQs
d. Neutrophils
e. Edema fluid
9- A nodule containing phagocytic cell which have undigested foreign matter (such as microorganism)
surrounded by lymphocytes & fibroblasts:
a. Lymph nodules
b. Lymph nodes
c. Phagosome
d. Granuloma
10- Immunological blood disorders of newborn are an example of which type of hypersensitivity:
a. Cytotoxic
b. Delayed
c. Immediate
d. Immune complex
11- Atopic diseases:
a. Caused by complement deficiency
b. Occur in compromised host
c. Allergies involving autoimmunity
d. Tendency to acquire them is genetically determined
12- Which of the following mediators is 1ry responsible for initial rapid reaction of anaphylaxis:
a. Prostaglandins
b. Leukotrienes
c. IL1
d. Histamine
13- Delayed type hypersensitivity works because of:
a. Development of cytotoxic T cells which are allergen specific
b. Depletion of IgE
c. Production of IgM against the allergen
d. High titer of blocking IgG
14- Urticaria is which type of hypersensitivity:
a. Cytotoxic
b. Immune complex
c. Delayed type
d. Immediate type
15- Mast cells & basophils differ from each other in which one of the following characteristics:
a. Inflammatory mediators are found in their granules
b. Immunological reactions in which they participate
c. Their site
d. Their ability to synthesize lipid mediators
8 9 10 11 12 13 14 15
c d a d d a d c
1- A patient develops hemolytic anaemia which is thought to be due to long term penicillin treatment which
is the correct type of hypersensitivity reactions:
a. Type I
b. Type II
c. Type III
d. Type IV
2- Type IV hypersensitivity response:
a. Are mediated by Ag-Ab complex
b. Occur within few hours after Ag contact
c. Occur in contact dermatitis
d. Occur in hay fever
3- 14 years old girl complains that every time she wears her new metal watch, the area of skin in contact with
the watch reveals: redness, edema, itchy vesicles within 12-24 hrs. This condition is mediated by:
a. Complement
b. IgE
c. IgM
d. Natural killer
e. T lymphocytes & MQs
4- You are performing a test on a fetus in its 7th month of gestation for possibility of erythroblastosis fetalis.
What ingredients would be necessary to perform this procedure: يشرح مع العملي
a. RBCs of fetus + Coomb's reagent
b. RBCs of fetus + mother's serum
c. Serum of fetus + RBCs of mother
d. Serum of baby + Coomb's reagent
5- Which is involved in post-streptococcal GN pathogenesis:
a. Ag-Ab complex , neutrophils & complement
b. Sensitized Th cells to glomerular basement membrane
c. Cytotoxic T cells reacting with glomerular basement membrane
d. IgE mediating eosinophil degranulation
6- 10 year old boy receives monthly injection of penicillin for management of rheumatic fever. This month
immediately within minutes of injection he develops difficulity in breathing, elevated itchy rash allover ! body,
vascular collapse, how can you explain this?
a. Arthus
b. Atopy
c. Cytotoxic hypersensitivity
d. Systemic anaphylaxis
e. Serum sickness
7- Serum sickness is mediated by:
a. Cytotoxic T cells
b. IgM , IgG & complement
c. Th cells
d. MQs
1 2 3 4 5 6 7
b c e a a d b
, 8- In tuberculin test, Induration & erythema reaction has a nodule filled with:
a. Mast cells
b. Oesinophils
c. Lymphocytes & MQs
d. Neutrophils
e. Edema fluid
9- A nodule containing phagocytic cell which have undigested foreign matter (such as microorganism)
surrounded by lymphocytes & fibroblasts:
a. Lymph nodules
b. Lymph nodes
c. Phagosome
d. Granuloma
10- Immunological blood disorders of newborn are an example of which type of hypersensitivity:
a. Cytotoxic
b. Delayed
c. Immediate
d. Immune complex
11- Atopic diseases:
a. Caused by complement deficiency
b. Occur in compromised host
c. Allergies involving autoimmunity
d. Tendency to acquire them is genetically determined
12- Which of the following mediators is 1ry responsible for initial rapid reaction of anaphylaxis:
a. Prostaglandins
b. Leukotrienes
c. IL1
d. Histamine
13- Delayed type hypersensitivity works because of:
a. Development of cytotoxic T cells which are allergen specific
b. Depletion of IgE
c. Production of IgM against the allergen
d. High titer of blocking IgG
14- Urticaria is which type of hypersensitivity:
a. Cytotoxic
b. Immune complex
c. Delayed type
d. Immediate type
15- Mast cells & basophils differ from each other in which one of the following characteristics:
a. Inflammatory mediators are found in their granules
b. Immunological reactions in which they participate
c. Their site
d. Their ability to synthesize lipid mediators
8 9 10 11 12 13 14 15
c d a d d a d c
