General Pediatrics Genetics
22 types are present from:
A- messenger RNA
B- ribosomal RNA
C- transfer RNA
D- hetergenous RNA
Types of RNA include all of the following except (Dec 2016)
A- messenger RNA
B- heterogenous RNA
C- mitochondrial RNA
D- transfer RNA
E- ribosomal RNA
Transcription means: (2013) (2014) (Oct 2018)
A- Replication of DNA
B- DNA sequence of each gene converted into mRNA strand
C- Joining of amino acids into a specific proteins
D- None of the above
Removing the non functional introns from mRNA is called (Dec 2015)
A- transcription
B- processing
C- translation
D- deletion
E- none of the above
Meiotic division is characterized by:
A- No synapses occur
B- Number of chromosomes is not affected
C- Occur only in germ cells
D- Presence of extra Barr body
Compared with meiosis, mitotic division (Oct 2016)
A- occurs only in germ cells
B- leads to separation of alleles
C- result in reduction of chromosomal numbers
D- all of the above
E- none of the above
( 30-31-32-33-34 )
, General Pediatrics Genetics
Genomic imprinting is an example of multi-factorial mode of inheritance ( F ) (2018)
In X linked recessive, the father never transmit the disease to his son ( T ) (Oct 2018)
X linked dominant is a disease of male ( F ) (Oct 2018)
Autosomal dominant is common in congangious marriage ( F ) (Dec 2019)
Mode of Prader Willi syndrome inheritance is (2013)
A- Multifactorial B- Mendelian inheritance
C- Maternal inheritance D- Genomic imprinting
A male patient 1 year old present to you with acute weakness of left side, vomiting
& Kaussmaul breathing. This disease is inherited as (A- mitochondrial inheritance)
A mentally retarded 4 year old, who was noted to be hypotonic at birth and had failure
to thrive in infancy, now has a tremendous appetite, obesity, hypogonadism and small
hands & feet. This disease is inherited as (Oct 2016)
A- Mitochondrial inheritance B- Mosaicism
C- Genomic imprinting D- Sex chromosomal imbalance
Recurrence risk in autosomal recessive disease is (2013)
A- 75% B- 25% C- 50% D- 100%
The following are inherited in an X linked manner, except (Oct 2013)
A- Duchene muscular dystrophy B- Hemophilia
C- Hunter disease D- Cystic fibrosis
The following are inherited in an X linked manner, except (Dec 2016)
A- familial hypophosphatemic rickets B- hemophilia A
C- favism D- thalassemia E- none of above
Which of the following is inherited as autosomal dominant trait (2014)
A- Hemophilia A B- Albinism
C- Achondroplasia D- Phenylketonuria
The following conditions have autosomal dominant inheritance, except
A- Achondroplasia B- Huntington chorea
C- Christmas disease D- Myotonia dystrophica E- Tuberous sclerosis
In X linked dominant disease, if mother is affected which is true (2014)
A- 100% children affected B- 25% female & 75% male child affected
C- 50% female & 50% male affected D- only 50% male child affected
Characteristic features of autosomal recessive inheritance include (Oct 2014)
A- 50% recurrence risk B- Both parents can be normal
C- More males are affected D- Consangious marriage is not a feature
A hemophilic father and free mother has on girl (Iman). Iman married to a free male,
Iman delivered a male child, she asked you to make circumcision, What will be your
answer? (Dec 2015)
A- Immediately B- After test for hemophilia
C- When become adult D- Circumcision is against law
Autosomal dominant disease (Dec 2015) (Dec 2019)
A- occur more in male B- usually result from consangious marriage
C- no carrier state present D- none of the above
Regarding Mendelian inheritance (Dec 2018)
A- AD is common in consangious marriage B- XD is a disease of male
C- In XR father never transmit to his son D- Mitochondrial inheritance is Mendelian
A genetic condition which is lethal in infancy is most likely to be
A- X linked structural protein defect B- Autosomal recessive enzyme deficiency
C- Autosomal dominant enzyme deficiency D- Autosomal dominant structural protein defect
( 35-36-37 )
22 types are present from:
A- messenger RNA
B- ribosomal RNA
C- transfer RNA
D- hetergenous RNA
Types of RNA include all of the following except (Dec 2016)
A- messenger RNA
B- heterogenous RNA
C- mitochondrial RNA
D- transfer RNA
E- ribosomal RNA
Transcription means: (2013) (2014) (Oct 2018)
A- Replication of DNA
B- DNA sequence of each gene converted into mRNA strand
C- Joining of amino acids into a specific proteins
D- None of the above
Removing the non functional introns from mRNA is called (Dec 2015)
A- transcription
B- processing
C- translation
D- deletion
E- none of the above
Meiotic division is characterized by:
A- No synapses occur
B- Number of chromosomes is not affected
C- Occur only in germ cells
D- Presence of extra Barr body
Compared with meiosis, mitotic division (Oct 2016)
A- occurs only in germ cells
B- leads to separation of alleles
C- result in reduction of chromosomal numbers
D- all of the above
E- none of the above
( 30-31-32-33-34 )
, General Pediatrics Genetics
Genomic imprinting is an example of multi-factorial mode of inheritance ( F ) (2018)
In X linked recessive, the father never transmit the disease to his son ( T ) (Oct 2018)
X linked dominant is a disease of male ( F ) (Oct 2018)
Autosomal dominant is common in congangious marriage ( F ) (Dec 2019)
Mode of Prader Willi syndrome inheritance is (2013)
A- Multifactorial B- Mendelian inheritance
C- Maternal inheritance D- Genomic imprinting
A male patient 1 year old present to you with acute weakness of left side, vomiting
& Kaussmaul breathing. This disease is inherited as (A- mitochondrial inheritance)
A mentally retarded 4 year old, who was noted to be hypotonic at birth and had failure
to thrive in infancy, now has a tremendous appetite, obesity, hypogonadism and small
hands & feet. This disease is inherited as (Oct 2016)
A- Mitochondrial inheritance B- Mosaicism
C- Genomic imprinting D- Sex chromosomal imbalance
Recurrence risk in autosomal recessive disease is (2013)
A- 75% B- 25% C- 50% D- 100%
The following are inherited in an X linked manner, except (Oct 2013)
A- Duchene muscular dystrophy B- Hemophilia
C- Hunter disease D- Cystic fibrosis
The following are inherited in an X linked manner, except (Dec 2016)
A- familial hypophosphatemic rickets B- hemophilia A
C- favism D- thalassemia E- none of above
Which of the following is inherited as autosomal dominant trait (2014)
A- Hemophilia A B- Albinism
C- Achondroplasia D- Phenylketonuria
The following conditions have autosomal dominant inheritance, except
A- Achondroplasia B- Huntington chorea
C- Christmas disease D- Myotonia dystrophica E- Tuberous sclerosis
In X linked dominant disease, if mother is affected which is true (2014)
A- 100% children affected B- 25% female & 75% male child affected
C- 50% female & 50% male affected D- only 50% male child affected
Characteristic features of autosomal recessive inheritance include (Oct 2014)
A- 50% recurrence risk B- Both parents can be normal
C- More males are affected D- Consangious marriage is not a feature
A hemophilic father and free mother has on girl (Iman). Iman married to a free male,
Iman delivered a male child, she asked you to make circumcision, What will be your
answer? (Dec 2015)
A- Immediately B- After test for hemophilia
C- When become adult D- Circumcision is against law
Autosomal dominant disease (Dec 2015) (Dec 2019)
A- occur more in male B- usually result from consangious marriage
C- no carrier state present D- none of the above
Regarding Mendelian inheritance (Dec 2018)
A- AD is common in consangious marriage B- XD is a disease of male
C- In XR father never transmit to his son D- Mitochondrial inheritance is Mendelian
A genetic condition which is lethal in infancy is most likely to be
A- X linked structural protein defect B- Autosomal recessive enzyme deficiency
C- Autosomal dominant enzyme deficiency D- Autosomal dominant structural protein defect
( 35-36-37 )
