NR 566 Week 6 Discussion Quiz Writer (Summer Term)

NR 566 Week 6 Discussion Quiz Writer (Summer Term)/WEEK 6QUIZ WRITERWhat are the mild symptoms of Alzheimer disease? Select all that apply.a.Problem with routine tasksb.Confusion and memory lossc.Wandering, pacingd.Difficulty recognizing friends and familye.Disorientation, getting lost in familiar surroundings Melinda a 75-year-old Caucasian female was prescribed by her nurse practitioner Donepezil.Patient wanted to know which medication can interact with this medication. Which of thefollowing medication can block the cholinergic receptors and reduce the therapeutic effects ofDonepezil?a.Diphenhydramineb.Metoprololc.Eliquisd.Atorvastatin A nurse practitioner is giving education to a patient that is recently prescribed with Tolcapone (Tasmar). What laboratory tests should the nurse practitioner monitor for this patient?a.CBCb.Liver Enzymesc.CMPd.All of the above Which of the following medication can cause aplastic anemia?a.Felbamateb.Lacosamidec.Topamaxd.PregabalinWhich of the following patients should avoid taking Ergot Alkaloids? Select all that apply.a.A 63-year-old female that is on hemodialysisb.A 78-year-old male that recently diagnosed with multi-vessel diseasec.A 47-year-old male with hypertensiond.An 86-year-old female with liver diseasee.A 38-year-old female with hyperlipidemiaANSWERS1.A,B,E (1,2,5) 2.A (1)3.B (2)4.A (1) 5.A,b,d (1,2,4)Response:Hello Diana,You have responded to all my questions correctly. I agree with all your rationales, and they haveexplained the answers very well. You have explained the importance of monitoring the liverenzymes of the medication Tolcapone (Tasmar). NP's should educate patients taking thismedication about the importance of how often they have to monitor their AST and ALT to avoidliver injury. It is the NP's responsibility that the patient verbally understands the instructionsprovided to them during their primary care visits.1. what are the 2 classes of drug classes used to treat Alzheimer's disease?A.NMDA Receptor antagonistB. COMP InhibitorsC. Ergot derivativeD.Cholinesterase inhibitorsE. Answers: A. NMDA Receptor antagonist & D. Cholinesterase inhibitorsRATIONALE:According to Rosenthal & Burchum (2021), the mechanism of action of cholinesterase inhibitors(AChE) is to prevent the breakdown of acetylcholine by acetylcholinesterase. In patients withmild Alzheimer's disease (AD), it enhances the transmission by the central cholinergic neuronsthat have not been destroyed. Cholinesterase inhibitors (AChE) are not a cure for AD, but theywill slow down AD progression. On the other hand, NMDA is a receptor antagonist used formoderate to severe AD patients to treat their symptoms. The mechanism of action of Memantine(NMDA receptor antagonist) modulates the effects of glutamate, which plays an essential role inlearning and memory. Patients with AD have a slow, steady leakage of glutamate from thepresynaptic neuron and surrounding glia which impairs the patient's memory and learning(Rosenthal & Burchum, 2021). 2. Drugs that decrease the beneficial effects of levodopa:A.AmantadineB. CarbidopaC. Antipsychotic drugsD.MAO inhibitors.Answer: C. Antipsychotic drugsRationale: According to Rosenthal & Burchum (2021), first-generation antipsychotic drugs likeHaldol and chlorpromazine blocks receptors for dopamine and can decrease the effects oflevodopa. However, the second-generation antipsychotic drugs do not block the dopaminereceptors and can be used for patients with Parkinson's Disease Rosenthal & Burchum (2021).