372 CAB01 Action Potential
PSL
on channels
specializedmacromoleculartransmembraneproteins
importantforbidirectionaltransportof lipidinsolubleions
requiredto generate
11 membranepotential dmaintaincellvolume
excitablea nonexcitablecells
21 actionpotentials excitablecells
s importantproperties
in ionconduction rapidrateacrossmembrane
21 selectivity ion specificity
31 gating openclosetospecificstimuli
voltagegatedligandgated mechanically gated
Membrane Potential cum definedrelativetocellexterior
dependson
D iondistributionacrossmembrane Ict Nat l l canbedescribedbyGoldman Hodgkin Katz eq
Membranepemeabilitytodifferentions y Um It
Kt o Pna that lot paler
In Pic
p piety t pna that sit PatelJi
iii
at restingmp.hr
membraneismostlypermeableto k t cplat p pNat
man
Inotvoltagegated voltagerequiredto maintaina particular is gradient
Kt Nat
Ewat t60mV
Cl outside
Ext goMV
11 kt ions Ear 70mV inside
since Kt s E KtJo Kttravelsoutward Iet out
KY
insidebecomesmorenegativerelative to outside redarrows Ex
Eventually Iactout Iactin duetoelectricalgradient
equilibriumpotential cent somv Rmp 70mV
4 depictedby Nernstear
in ex o
Ex
II ex
21 Nations
Natso s Nat
inwardNatcurrent
wever permeability to wat cats is
antetype
si et ions
TenTo s tri
pet isverysmall
Targe c
ilychafedproteinsinsidecellkeeps a
ionsoutside
PSL
on channels
specializedmacromoleculartransmembraneproteins
importantforbidirectionaltransportof lipidinsolubleions
requiredto generate
11 membranepotential dmaintaincellvolume
excitablea nonexcitablecells
21 actionpotentials excitablecells
s importantproperties
in ionconduction rapidrateacrossmembrane
21 selectivity ion specificity
31 gating openclosetospecificstimuli
voltagegatedligandgated mechanically gated
Membrane Potential cum definedrelativetocellexterior
dependson
D iondistributionacrossmembrane Ict Nat l l canbedescribedbyGoldman Hodgkin Katz eq
Membranepemeabilitytodifferentions y Um It
Kt o Pna that lot paler
In Pic
p piety t pna that sit PatelJi
iii
at restingmp.hr
membraneismostlypermeableto k t cplat p pNat
man
Inotvoltagegated voltagerequiredto maintaina particular is gradient
Kt Nat
Ewat t60mV
Cl outside
Ext goMV
11 kt ions Ear 70mV inside
since Kt s E KtJo Kttravelsoutward Iet out
KY
insidebecomesmorenegativerelative to outside redarrows Ex
Eventually Iactout Iactin duetoelectricalgradient
equilibriumpotential cent somv Rmp 70mV
4 depictedby Nernstear
in ex o
Ex
II ex
21 Nations
Natso s Nat
inwardNatcurrent
wever permeability to wat cats is
antetype
si et ions
TenTo s tri
pet isverysmall
Targe c
ilychafedproteinsinsidecellkeeps a
ionsoutside
