1
MCQs of Antiseizure
(Anti Epileptic)
001. The mechanism of action of antiseizure drugs is:
a) Enhancement of GABAergic (inhibitory) transmission
b) Diminution of excitatory (usually glutamatergic) transmission
c) Modification of ionic conductance
d) All of the above mechanisms
Answer d
002. Which of the following antiseizure drugs produces enhancement of GABA-mediated inhibition?
a) Ethosuximide
b) Carbamazepine
c) Phenobarbital
d) Lamotrigine
Answer c
003. Indicate an antiseizure drug, which has an impotent effect on the T-type calcium channels in
thalamic neurons?
a) Carbamazepin
b) Lamotrigine
c) Ethosuximide
d) Phenytoin
Answer c
004. Which of the following antiseizure drugs produces a voltage-dependent inactivation of sodium
channels?
a) Lamotrigine
b) Carbamazepin
c) Phenytoin
d) All of the above
Answer d
005. Indicate an antiseizure drug, inhibiting central effects of excitatory amino acids:
a) Ethosuximide
b) Lamotrigine
c) Diazepam
d) Tiagabine
Answer b
By Abdulogy www.md.ly
Libyan Medical Network
, 2
006. The drug for partial and generalized tonic-clonic seizures is:
a) Carbamazepine
b) Valproate
c) Phenytoin
d) All of the above
Answer d
007. Indicate an anti-absence drug:
a) Valproate
b) Phenobarbital
c) Carbamazepin
d) Phenytoin
Answer a
008. The drug against myoclonic seizures is:
a) Primidone
b) Carbamazepine
c) Clonazepam
d) Phenytoin
Answer c
009. The most effective drug for stopping generalized status epilepticus in adults is:
a) Lamotrigine
b) Ethosuximide
c) Diazepam
d) Zonisamide
Answer c
010. Select the appropriate consideration for phenytoin:
a) It blocks sodium channels
b) It binds to an allosteric regulatory site on the GABA-BZ receptor and prolongs the openings of
the Cl-channels
c) It effects on Ca2+ currents, reducing the low-threshold (T-type) current
d) It inhibits GABA-transaminase, which catalyzes the breakdown of GABA
Answer a
011. Phenytoin is used in the treatment of:
a) Petit mal epilepsy
b) Grand mal epilepsy
c) Myoclonic seizures
d) All of the above
Answer b
012. Dose-related adverse effect caused by phenytoin is:
a) Physical and psychological dependence
b) Exacerbated grand mal epilepsy
c) Gingival hyperplasia
d) Extrapyramidal symptoms
Answer c
By Abdulogy www.md.ly
Libyan Medical Network
MCQs of Antiseizure
(Anti Epileptic)
001. The mechanism of action of antiseizure drugs is:
a) Enhancement of GABAergic (inhibitory) transmission
b) Diminution of excitatory (usually glutamatergic) transmission
c) Modification of ionic conductance
d) All of the above mechanisms
Answer d
002. Which of the following antiseizure drugs produces enhancement of GABA-mediated inhibition?
a) Ethosuximide
b) Carbamazepine
c) Phenobarbital
d) Lamotrigine
Answer c
003. Indicate an antiseizure drug, which has an impotent effect on the T-type calcium channels in
thalamic neurons?
a) Carbamazepin
b) Lamotrigine
c) Ethosuximide
d) Phenytoin
Answer c
004. Which of the following antiseizure drugs produces a voltage-dependent inactivation of sodium
channels?
a) Lamotrigine
b) Carbamazepin
c) Phenytoin
d) All of the above
Answer d
005. Indicate an antiseizure drug, inhibiting central effects of excitatory amino acids:
a) Ethosuximide
b) Lamotrigine
c) Diazepam
d) Tiagabine
Answer b
By Abdulogy www.md.ly
Libyan Medical Network
, 2
006. The drug for partial and generalized tonic-clonic seizures is:
a) Carbamazepine
b) Valproate
c) Phenytoin
d) All of the above
Answer d
007. Indicate an anti-absence drug:
a) Valproate
b) Phenobarbital
c) Carbamazepin
d) Phenytoin
Answer a
008. The drug against myoclonic seizures is:
a) Primidone
b) Carbamazepine
c) Clonazepam
d) Phenytoin
Answer c
009. The most effective drug for stopping generalized status epilepticus in adults is:
a) Lamotrigine
b) Ethosuximide
c) Diazepam
d) Zonisamide
Answer c
010. Select the appropriate consideration for phenytoin:
a) It blocks sodium channels
b) It binds to an allosteric regulatory site on the GABA-BZ receptor and prolongs the openings of
the Cl-channels
c) It effects on Ca2+ currents, reducing the low-threshold (T-type) current
d) It inhibits GABA-transaminase, which catalyzes the breakdown of GABA
Answer a
011. Phenytoin is used in the treatment of:
a) Petit mal epilepsy
b) Grand mal epilepsy
c) Myoclonic seizures
d) All of the above
Answer b
012. Dose-related adverse effect caused by phenytoin is:
a) Physical and psychological dependence
b) Exacerbated grand mal epilepsy
c) Gingival hyperplasia
d) Extrapyramidal symptoms
Answer c
By Abdulogy www.md.ly
Libyan Medical Network
