Summary Addison’s Disease vs Cushing’s Disease.

Addison’s Disease vs Cushing’s Disease




ADDISON’S DISEASE CUSHING’S DISEASE


Hyposecretion of adrenocortical hormones
leading to:



● Metabolic disturbances (sugar)
Hypersecretion of
Definition ● Fluid and electrolyte imbalances
adrenocortical hormone
(salt)
● Deficiency of neuromuscular
function (salt and sex)

, 1. Hyperplasia of
Adrenal gland
Predisposing
2. Tubercular infection
Factors
1. Atrophy of the Adrenal gland (MILIARY – TB to
2. Fungal infections adjacent organs)




1. hypoglycemia (TIRED)
1. Hyperglycemia à
○ Tremors and
can lead to DM
tachycardia
1. Polyuria
○ Irritability
2. Polydipsi
○ Restlessness
a
○ Extreme fatigue
3. Polyphag
○ Diaphoresis and
ia
depression
4. Wt. Gain
2. Decreased tolerance to stress
5. Glucosuri
(d/t decreased cortisol) à
a
Signs and Addisonian Crisis
2. Increased
3. Hyponatremia
susceptibility to
Symptoms ○ Hypotension
infection (Reverse
○ Signs of dehydration
isolation!)
○ Weight loss
3. Hypernatremia
4. Hyperkalemia
1. HPN
○ Irritability and
2. Edema
agitation
3. Wt. gain
○ Diarrhea
4. Moonface
○ Arrhythmias
appearance, buffalo
5. Decreased Libido
hump, obese trunk,
6. Loss of pubic and axillary hair
pendulous
7. Bronze-like skin pigmentation
abdomen, thin
d/t decreased cortisolà
extremities
stimulation of MSH from
5. Hypokalemia
pituitary gland