Septic Shock
What is septic shock?
Shock is a condition manifesting hemodynamic changes (e.g. hypotension,
tachycardia, low cardiac output [CO] and oliguria) caused by intravascular
volume deficit, myocardial pump failure (cardiogenic shock), or peripheral
vasodilation (septic, anaphylactic or neurogenic shock).
Septic shock is the shock that is accompanied by an infection (source of
infection). This shock occurs due to the spread or invasion of germs and their
toxins in the body which results in vasodilation. In hypoxic septic shock, the cells
that occur are not caused by decreased tissue perfusion but due to the inability of
cells to use oxygen due to germ toxins.
What is the cause of septic shock?
The greatest cause is gram-negative bacteria. The product that plays an important
role in sepsis is lipopolysaccharide (LPS), which is the outermost component of
gram-negative bacteria. LPS is the most common cause of sepsis, can directly
activate the cellular and humoral immune system, which can cause symptoms of
septicemia.
What are the symptoms?
It is usually preceded by fever, chills, and concomitant symptoms such as
weakness, malaise, restlessness or confusion. The most common sites of infection:
lung, digestive tract, urinary tract, skin, soft tissue, and central nervous system.
Sepsis symptoms will be more severe in the elderly, diabetics, cancer, major
organ failure, and patients with granulocytopenia. Signs of MODS with the
occurrence of complications:
a. Respiratory distress syndrome in adults
b. Intravascular coagulation
c. Acute renal failure
d. Intestinal bleeding
e. Liver failure
f. Central nervous system dysfunction
g. Heart failure
h. Death
What is septic shock?
Shock is a condition manifesting hemodynamic changes (e.g. hypotension,
tachycardia, low cardiac output [CO] and oliguria) caused by intravascular
volume deficit, myocardial pump failure (cardiogenic shock), or peripheral
vasodilation (septic, anaphylactic or neurogenic shock).
Septic shock is the shock that is accompanied by an infection (source of
infection). This shock occurs due to the spread or invasion of germs and their
toxins in the body which results in vasodilation. In hypoxic septic shock, the cells
that occur are not caused by decreased tissue perfusion but due to the inability of
cells to use oxygen due to germ toxins.
What is the cause of septic shock?
The greatest cause is gram-negative bacteria. The product that plays an important
role in sepsis is lipopolysaccharide (LPS), which is the outermost component of
gram-negative bacteria. LPS is the most common cause of sepsis, can directly
activate the cellular and humoral immune system, which can cause symptoms of
septicemia.
What are the symptoms?
It is usually preceded by fever, chills, and concomitant symptoms such as
weakness, malaise, restlessness or confusion. The most common sites of infection:
lung, digestive tract, urinary tract, skin, soft tissue, and central nervous system.
Sepsis symptoms will be more severe in the elderly, diabetics, cancer, major
organ failure, and patients with granulocytopenia. Signs of MODS with the
occurrence of complications:
a. Respiratory distress syndrome in adults
b. Intravascular coagulation
c. Acute renal failure
d. Intestinal bleeding
e. Liver failure
f. Central nervous system dysfunction
g. Heart failure
h. Death
