Chapter 8 practice questions metabolism and toxicology.

1. Oncogenes:
- can be mutated to form proto-oncogenes.
2. Which of the following is NOT one of the more common sources of DNA
damage?
- x-rays.
3. Which of the following pairs of DNA repair mechanisms is most likely to
introduce mutations into the genetic composition of an organism?
- homologous recombination and mismatch repair.
4. Which of the following DNA mutations would NOT be considered a frameshift
mutation?
- insertion of 7 nucleotides.
5. Which of the following base pair mutations is properly characterized as a
transversion mutation?
- G → A.
6. All of the following statements regarding nondisjunction during meiosis are
true EXCEPT:
- Nondisjunction events can happen during meiosis I or meiosis II.
7. Which of the following diseases does NOT have a recessive inheritance
pattern?
- sickle cell anemia.
8. What is the purpose of the Ames assay?
- to measure induction of phenotypic changes in Drosophila.
9. In mammalian cytogenic assays, chromosomal aberrations are measured after
treatment of the cells at which sensitive phase of the cell cycle?
- S phase.
10. Which of the following molecules is used to gauge the amount of a specific
gene being transcribed to mRNA?
- mRNA.