SKIP
TO:
BLOCK
1
BLOCK
2
NBME 2 BLOCK 1-4
BLOCK
3
BLOCK
4
,*Lipopolysacharides(Bacteria)
LPS bind to "Toll-like receptor"(TLR) (a single Transmembrane receptor)------> activation of
Inhibitory kappa B kinase (IKB kinase)------->
Note: NF-kB is a transcription Factor that exist in cytoplasm bound to Inhibitory kappa B
(IKB) protein in Inactive form [NF-kB=IKB]
so continuing the above sequence ..
LPS----> TLR---->+IKB kinase----->phosphorylation of IKB of the complex[NF-kB=IKB] and
now this phosphorylated IKB get degraded and NF-kB is released----->NF-kB move to Nucleus
where it upregulate gene expression of TNF------>Sepsis
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,
TO:
BLOCK
1
BLOCK
2
NBME 2 BLOCK 1-4
BLOCK
3
BLOCK
4
,*Lipopolysacharides(Bacteria)
LPS bind to "Toll-like receptor"(TLR) (a single Transmembrane receptor)------> activation of
Inhibitory kappa B kinase (IKB kinase)------->
Note: NF-kB is a transcription Factor that exist in cytoplasm bound to Inhibitory kappa B
(IKB) protein in Inactive form [NF-kB=IKB]
so continuing the above sequence ..
LPS----> TLR---->+IKB kinase----->phosphorylation of IKB of the complex[NF-kB=IKB] and
now this phosphorylated IKB get degraded and NF-kB is released----->NF-kB move to Nucleus
where it upregulate gene expression of TNF------>Sepsis
,Loading...
,
