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Histological features include epithelial tubules, areas of necrosis, immature glomerular
structures, stroma with spindle cells and small cell blastomatous tissues resembling the
metanephric blastema
,Question 1 of 104
A 27-year-old man is investigated for haemoptysis. He is a non-smoker and has no respiratory history
of note. Whilst awaiting a bronchoscopy he becomes lethargic and anorexic. Blood tests show the
following:
Na+ 141 mmol/l
K+ 5.3 mmol/l
Urea 16.7 mmol/l
Creatinine 271 µmol/l
A renal biopsy is performed and shows linear IgG deposits along the basement membrane
What type of antibodies are most likely to cause this type of presentation?
cANCA
IgA
pANCA
Anti-nuclear antibodies (ANA)
Anti-glomerular basement membrane (anti-GBM) antibodies
,Question 1 of 104
A 27-year-old man is investigated for haemoptysis. He is a non-smoker and has no respiratory history
of note. Whilst awaiting a bronchoscopy he becomes lethargic and anorexic. Blood tests show the
following:
Na+ 141 mmol/l
K+ 5.3 mmol/l
Urea 16.7 mmol/l
Creatinine 271 µmol/l
A renal biopsy is performed and shows linear IgG deposits along the basement membrane.
What type of antibodies are most likely to cause this type of presentation?
cANCA
IgA
pANCA
Anti-nuclear antibodies (ANA)
Anti-glomerular basement membrane (anti-GBM) antibodies
Goodpasture's syndrome
IgG deposits on renal biopsy
anti-GBM antibodies
tsis, renal failure and linear IgG deposits points to a diagnosis of
Goodpasture's syndrome.
-related nephropathies are associated with crescentic glomerulonephritis.
Discuss and give feedback
Goodpasture's syndrome
, Question 2 of 104
A 24-year-old woman is diagnosed as having nephrotic syndrome after being investigated for
proteinuria. A diagnosis of minimal change glomerulonephritis is made. What is the most
appropriate initial treatment to reduce proteinuria?
Protein restriction in diet
No treatment shown to effective
Angiotensin-converting-enzyme inhibitor
Diuretic
Prednisolone
Histological features include epithelial tubules, areas of necrosis, immature glomerular
structures, stroma with spindle cells and small cell blastomatous tissues resembling the
metanephric blastema
,Question 1 of 104
A 27-year-old man is investigated for haemoptysis. He is a non-smoker and has no respiratory history
of note. Whilst awaiting a bronchoscopy he becomes lethargic and anorexic. Blood tests show the
following:
Na+ 141 mmol/l
K+ 5.3 mmol/l
Urea 16.7 mmol/l
Creatinine 271 µmol/l
A renal biopsy is performed and shows linear IgG deposits along the basement membrane
What type of antibodies are most likely to cause this type of presentation?
cANCA
IgA
pANCA
Anti-nuclear antibodies (ANA)
Anti-glomerular basement membrane (anti-GBM) antibodies
,Question 1 of 104
A 27-year-old man is investigated for haemoptysis. He is a non-smoker and has no respiratory history
of note. Whilst awaiting a bronchoscopy he becomes lethargic and anorexic. Blood tests show the
following:
Na+ 141 mmol/l
K+ 5.3 mmol/l
Urea 16.7 mmol/l
Creatinine 271 µmol/l
A renal biopsy is performed and shows linear IgG deposits along the basement membrane.
What type of antibodies are most likely to cause this type of presentation?
cANCA
IgA
pANCA
Anti-nuclear antibodies (ANA)
Anti-glomerular basement membrane (anti-GBM) antibodies
Goodpasture's syndrome
IgG deposits on renal biopsy
anti-GBM antibodies
tsis, renal failure and linear IgG deposits points to a diagnosis of
Goodpasture's syndrome.
-related nephropathies are associated with crescentic glomerulonephritis.
Discuss and give feedback
Goodpasture's syndrome
, Question 2 of 104
A 24-year-old woman is diagnosed as having nephrotic syndrome after being investigated for
proteinuria. A diagnosis of minimal change glomerulonephritis is made. What is the most
appropriate initial treatment to reduce proteinuria?
Protein restriction in diet
No treatment shown to effective
Angiotensin-converting-enzyme inhibitor
Diuretic
Prednisolone
