conformation and configuration
,Three-Dimensional Structure Is Described by Configuration and Confor
• The covalent bonds and functional groups of a biomolecule ar
course, central to its function, but so also is the arrangement o
molecule’s constituent atoms in three-dimensional space
stereochemistry.
• Carbon containing compounds commonly exist as stereoisom
molecules with the same chemical bonds and same chemical for
but different configuration, the fixed spatial arrangement of a
Interactions between biomolecules are invariably stereospe
requiring specific configurations in the interacting molecules.
, Configuration is conferred by the presence of either
(1) double bonds, around which there is little or no freedom of rotation,
(2) chiral centers, around which substituent groups are arranged in a
orientation.
The identifying characteristic of stereoisomers is that they can
interconverted without temporarily breaking one or more covalent
shows the configurations of maleic acid and its isomer, fumaric acid.
These compounds are geometric or isomers, or cis-trans isomers; the
in the arrangement of their substituent groups with respect to the non
double bond (Latin cis, “on this side”-groups on the same side of the
bond; trans, “across”-groups on opposite sides)
,Three-Dimensional Structure Is Described by Configuration and Confor
• The covalent bonds and functional groups of a biomolecule ar
course, central to its function, but so also is the arrangement o
molecule’s constituent atoms in three-dimensional space
stereochemistry.
• Carbon containing compounds commonly exist as stereoisom
molecules with the same chemical bonds and same chemical for
but different configuration, the fixed spatial arrangement of a
Interactions between biomolecules are invariably stereospe
requiring specific configurations in the interacting molecules.
, Configuration is conferred by the presence of either
(1) double bonds, around which there is little or no freedom of rotation,
(2) chiral centers, around which substituent groups are arranged in a
orientation.
The identifying characteristic of stereoisomers is that they can
interconverted without temporarily breaking one or more covalent
shows the configurations of maleic acid and its isomer, fumaric acid.
These compounds are geometric or isomers, or cis-trans isomers; the
in the arrangement of their substituent groups with respect to the non
double bond (Latin cis, “on this side”-groups on the same side of the
bond; trans, “across”-groups on opposite sides)
