PHARM 180 WEEK 2 QUIZ REVIEW| VERIFIED GUIDE

PHARM 180 WEEK 2 QUIZ REVIEW● Drugs for Peptic Ulcer Disease ○ ulcer/erosion that occurs in esophagus, stomach, duodenum (most common area) ○ Forms when : mucosal layer breaks down, insufficient buffers in intestine to neutralize stomach, defective sphincter muscles (upper and lower) , hypermotility of stomach ○ Spicy, alco, nicotine use can put pt more at risk Histamine2-receptor antagonists – famotidine (Pepcid) ● Therapeutic use: Treat gastric and duodenal ulcers, heartburn and dyspepsia, GERD, aspiration pneumonitis ● Also treat hypersecretory dz: zollinger-ellison syndrome (increases production of gastric=increase production of histamine ○ Prototype: famotidine (pepcid) - Classification: Histamine H2 Antagonists ○ Pharmacological Action ■ block histamine receptors in the stomach that are responsible for secreting stomach acid. Increase pH ○ Complications ■ Impotence, gynecomastia, reduced libido, N/V/D, constipation, dizzy ■ may occur - confusion, arrhythmias, agranulocytosis, aplastic anemia ○ Administration ■ Orally, intramuscularly, or IV ■ With or without food bc no difference in absorption, daily at bedtime ○ Interaction : No antacids potential decrease absorption of H2 antagonists. No smoking bc of decreased effectiveness ○ Nursing Considerations: ■ Avoid - smoking. alcohol, aspirin, monitor for GI irritation ○ Contraindications/ precautions