TEST BANK
ABRAMS’ CLINICAL DRUG THERAPY RATIONALES FOR NURSING
PRACTICE 12TH EDITION
GERALYN FRANDSEN
,Test Generator Questions, Chapter 1, The Foundation of
Pharmacology: Quality and Safety
1. A woman diagnosed with obsessive–compulsive disorder has been prescribed
oral paroxetine hydrochloride. What is the expected effect for this prescription?
A. Curative effect on symptoms
B. Systemic effect on symptoms
C. Local effect on symptoms
D. Parenteral effect on symptoms
Answer: B
Rationale: Drugs that produce systemic effects are taken into the body, circulated
through the bloodstream to their sites of action in various body tissues, and
eventually eliminated from the body. Curative agents are given to cure a disease
process. In this case, paroxetine hydrochloride will control the symptoms but not
cure the disorder. Drugs with local effects, such as sunscreen and local anesthetics,
act mainly at the site of application. Paroxetine hydrochloride is not administered
parenterally. Parenteral agents are administered subcutaneously, intramuscularly,
or intravenously.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 1
Reference: p. 3, Introduction
2. A client has been prescribed an antibiotic. This medication is a naturally
occurring substance that has been chemically modified. What is another name for
this type of medication?
A. Synthetic drug
B. Semisynthetic drug
C. Biotechnology drug
D. Prototype drug
,Answer: B
Rationale: Semisynthetic drugs (e.g., many antibiotics) are naturally occurring
substances that have been chemically modified. Synthetic drugs are more
standardized in their chemical characteristics, more consistent in their effects, and
less likely to produce allergic reactions. Biotechnology drugs involve manipulating
DNA and RNA and recombining genes into hybrid molecules that can be inserted
into living organisms. Prototype drugs are the first drug of a particular group to be
developed.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 1
Reference: p. 3, Drug Sources
3. Which classification applies to morphine?
A. Central nervous system depressant
B. Central nervous system stimulant
C. Anti-inflammatory
D. Antihypertensive
Answer: A
Rationale: Drugs are classified according to their effects on particular body
systems, their therapeutic uses, and their chemical characteristics. Morphine is
classified as a central nervous system depressant and will produce this effect in the
client. A central nervous system stimulant increases attention and raises mood. An
anti-inflammatory agent decreases inflammation at the site of tissue or joint
inflammation. An antihypertensive agent reduces blood pressure.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Remember
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 1
Reference: p. 3, Drug Classifications and Prototypes
,4. A client is administered amoxicillin. The generic name of this medication belongs
to which drug group?
A. Selective serotonin reuptake inhibitors
B. Diuretics
C. Penicillins
D. ACE inhibitors
Answer: C
Rationale: The generic name often indicates the drug group (e.g., drugs with
generic names ending in “cillin” are penicillins). Selective serotonin reuptake
inhibitors are medications that have antidepressant effects; SSRI is a broad
classification, not a generic name. Diuretics are medications that increase urine
output; diuretic is a broad classification, not a generic name. ACE inhibitor is the
broad classification for the angiotensin receptor blockers, not the generic name.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 2
Reference: p. 3, Drug Names
5. The administration of diphenhydramine is regulated by which U.S. government
agency?
A. Public Health Service
B. Federal Trade Commission
C. Occupational Safety and Health Administration
D. Food and Drug Administration
Answer: D
Rationale: The Food and Drug Administration approves drugs for over-the-counter
availability, including the transfer of drugs from prescription to OTC status, and
,may require clinical trials to determine the safety and effectiveness of OTC use. The
Public Health Service is regulated by the state to maintain the health of individual
citizens of the state. The Federal Trade Commission regulates imports and exports
throughout the nation. The Occupational Safety and Health Administration regulates
safety within the workplace.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 4
Reference: p. 4, Prescription and Nonprescription Drugs
6. In the U.S., the administration of anabolic steroids is regulated by which law?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Comprehensive Drug Abuse Prevention and Control Act
C. The Harrison Narcotic Act
D. The Sherley Amendment
Answer: B
Rationale: The Comprehensive Drug Abuse Prevention and Control Act regulates the
manufacture and distribution of narcotics, stimulants, depressants, hallucinogens,
and anabolic steroids. The Food, Drug, and Cosmetic Act of 1938 revised and
broadened FDA powers and responsibilities, giving the FDA control over drug
safety. The Harrison Narcotic Act restricted the importation, manufacture, sale, and
use of opium, cocaine, marijuana, and other drugs that the act defined as narcotics.
The Sherley Amendment of 1912 prohibited fraudulent claims of drug effectiveness.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Remember
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 3
Reference: p. 4, Prescription and Nonprescription Drugs
7. A nurse is responsible for maintaining an accurate count and record of the
controlled substances on the nursing division. This nursing action is regulated by
, which U.S. law or agency?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Public Health Service
C. The Drug Enforcement Administration
D. The Sherley Amendment
Answer: C
Rationale: The Drug Enforcement Administration enforces the Controlled
Substances Act. Under this enforcement, nurses are responsible for storing
controlled substances in locked containers, administering them only to the people
for whom they are prescribed, recording each dose given, and maintaining an
accurate inventory. The Food, Drug, and Cosmetic Act of 1938 revised and
broadened FDA powers and responsibilities, giving the FDA control over drug
safety. The Public Health Service is regulated by the state to maintain the health of
individual citizens of the state. The Sherley Amendment of 1912 prohibited
fraudulent claims of drug effectiveness.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 4
Reference: p. 7, Testing Procedure
8. In Phase 1 clinical trials, the potential uses and effects of a new drug are
determined by which method?
A. Administering doses to healthy volunteers
B. Administering doses to people with the disease
C. Administering in placebo-controlled design
D. Calculating the risk-to-benefit ratio
Answer: A
Rationale: Phase 1 studies allow for the administration of the medication to healthy
volunteers to determine safe dosages, routes of administration, absorption,
metabolism, excretion, and toxicity. In Phase 2 studies, a few doses are given to a
certain number of subjects with the disease or symptom for which the drug is being
ABRAMS’ CLINICAL DRUG THERAPY RATIONALES FOR NURSING
PRACTICE 12TH EDITION
GERALYN FRANDSEN
,Test Generator Questions, Chapter 1, The Foundation of
Pharmacology: Quality and Safety
1. A woman diagnosed with obsessive–compulsive disorder has been prescribed
oral paroxetine hydrochloride. What is the expected effect for this prescription?
A. Curative effect on symptoms
B. Systemic effect on symptoms
C. Local effect on symptoms
D. Parenteral effect on symptoms
Answer: B
Rationale: Drugs that produce systemic effects are taken into the body, circulated
through the bloodstream to their sites of action in various body tissues, and
eventually eliminated from the body. Curative agents are given to cure a disease
process. In this case, paroxetine hydrochloride will control the symptoms but not
cure the disorder. Drugs with local effects, such as sunscreen and local anesthetics,
act mainly at the site of application. Paroxetine hydrochloride is not administered
parenterally. Parenteral agents are administered subcutaneously, intramuscularly,
or intravenously.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 1
Reference: p. 3, Introduction
2. A client has been prescribed an antibiotic. This medication is a naturally
occurring substance that has been chemically modified. What is another name for
this type of medication?
A. Synthetic drug
B. Semisynthetic drug
C. Biotechnology drug
D. Prototype drug
,Answer: B
Rationale: Semisynthetic drugs (e.g., many antibiotics) are naturally occurring
substances that have been chemically modified. Synthetic drugs are more
standardized in their chemical characteristics, more consistent in their effects, and
less likely to produce allergic reactions. Biotechnology drugs involve manipulating
DNA and RNA and recombining genes into hybrid molecules that can be inserted
into living organisms. Prototype drugs are the first drug of a particular group to be
developed.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 1
Reference: p. 3, Drug Sources
3. Which classification applies to morphine?
A. Central nervous system depressant
B. Central nervous system stimulant
C. Anti-inflammatory
D. Antihypertensive
Answer: A
Rationale: Drugs are classified according to their effects on particular body
systems, their therapeutic uses, and their chemical characteristics. Morphine is
classified as a central nervous system depressant and will produce this effect in the
client. A central nervous system stimulant increases attention and raises mood. An
anti-inflammatory agent decreases inflammation at the site of tissue or joint
inflammation. An antihypertensive agent reduces blood pressure.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Remember
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 1
Reference: p. 3, Drug Classifications and Prototypes
,4. A client is administered amoxicillin. The generic name of this medication belongs
to which drug group?
A. Selective serotonin reuptake inhibitors
B. Diuretics
C. Penicillins
D. ACE inhibitors
Answer: C
Rationale: The generic name often indicates the drug group (e.g., drugs with
generic names ending in “cillin” are penicillins). Selective serotonin reuptake
inhibitors are medications that have antidepressant effects; SSRI is a broad
classification, not a generic name. Diuretics are medications that increase urine
output; diuretic is a broad classification, not a generic name. ACE inhibitor is the
broad classification for the angiotensin receptor blockers, not the generic name.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 2
Reference: p. 3, Drug Names
5. The administration of diphenhydramine is regulated by which U.S. government
agency?
A. Public Health Service
B. Federal Trade Commission
C. Occupational Safety and Health Administration
D. Food and Drug Administration
Answer: D
Rationale: The Food and Drug Administration approves drugs for over-the-counter
availability, including the transfer of drugs from prescription to OTC status, and
,may require clinical trials to determine the safety and effectiveness of OTC use. The
Public Health Service is regulated by the state to maintain the health of individual
citizens of the state. The Federal Trade Commission regulates imports and exports
throughout the nation. The Occupational Safety and Health Administration regulates
safety within the workplace.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 4
Reference: p. 4, Prescription and Nonprescription Drugs
6. In the U.S., the administration of anabolic steroids is regulated by which law?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Comprehensive Drug Abuse Prevention and Control Act
C. The Harrison Narcotic Act
D. The Sherley Amendment
Answer: B
Rationale: The Comprehensive Drug Abuse Prevention and Control Act regulates the
manufacture and distribution of narcotics, stimulants, depressants, hallucinogens,
and anabolic steroids. The Food, Drug, and Cosmetic Act of 1938 revised and
broadened FDA powers and responsibilities, giving the FDA control over drug
safety. The Harrison Narcotic Act restricted the importation, manufacture, sale, and
use of opium, cocaine, marijuana, and other drugs that the act defined as narcotics.
The Sherley Amendment of 1912 prohibited fraudulent claims of drug effectiveness.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Remember
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 3
Reference: p. 4, Prescription and Nonprescription Drugs
7. A nurse is responsible for maintaining an accurate count and record of the
controlled substances on the nursing division. This nursing action is regulated by
, which U.S. law or agency?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Public Health Service
C. The Drug Enforcement Administration
D. The Sherley Amendment
Answer: C
Rationale: The Drug Enforcement Administration enforces the Controlled
Substances Act. Under this enforcement, nurses are responsible for storing
controlled substances in locked containers, administering them only to the people
for whom they are prescribed, recording each dose given, and maintaining an
accurate inventory. The Food, Drug, and Cosmetic Act of 1938 revised and
broadened FDA powers and responsibilities, giving the FDA control over drug
safety. The Public Health Service is regulated by the state to maintain the health of
individual citizens of the state. The Sherley Amendment of 1912 prohibited
fraudulent claims of drug effectiveness.
Question format: Multiple Choice
Chapter 1: The Foundation of Pharmacology: Quality and Safety
Cognitive Level: Understand
Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
Integrated Process: Nursing process
Objective: 4
Reference: p. 7, Testing Procedure
8. In Phase 1 clinical trials, the potential uses and effects of a new drug are
determined by which method?
A. Administering doses to healthy volunteers
B. Administering doses to people with the disease
C. Administering in placebo-controlled design
D. Calculating the risk-to-benefit ratio
Answer: A
Rationale: Phase 1 studies allow for the administration of the medication to healthy
volunteers to determine safe dosages, routes of administration, absorption,
metabolism, excretion, and toxicity. In Phase 2 studies, a few doses are given to a
certain number of subjects with the disease or symptom for which the drug is being
