TEST BANK
ABRAMS’ CLINICAL DRUG THERAPY RATIONALES FOR NURSING
PRACTICE 12TH EDITION
GERALYN FRANDSEN
,Chapter 1, The Foundation of Pharmacology: Quality and Safety
1. A woman diagnosed with obsessive–compulsive disorder has been prescribed oral
paroxetine hydrochloride. What is the expected effect for this prescription?
A. Curative effect on symptoms
B. Systemic effect on symptoms
C. Local effect on symptoms
D. Parenteral effect on symptoms
ANS: B
Rationale: Drugs that produce systemic effects are taken into the body, circulated through
the bloodstream to their sites of action in various body tissues, and eventually eliminated
from the body. Curative agents are given to cure a disease process. In this case, paroxetine
hydrochloride will control the symptoms but not cure the disorder. Drugs with local effects,
such as sunscreen and local anesthetics, act mainly at the site of application. Paroxetine
hydrochloride is not administered parenterally. Parenteral agents are administered
subcutaneously, intramuscularly, or intravenously.
PTS: 1 REF: p. 3, Introduction OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
2. A client has been prescribed an antibiotic. This medication is a naturally occurring
substance that has been chemically modified. What is another name for this type of
medication?
A. Synthetic drug
B. Semisynthetic drug
C. Biotechnology drug
D. Prototype drug
ANS: B
Rationale: Semisynthetic drugs (e.g., many antibiotics) are naturally occurring substances
that have been chemically modified. Synthetic drugs are more standardized in their chemical
characteristics, more consistent in their effects, and less likely to produce allergic reactions.
Biotechnology drugs involve manipulating DNA and RNA and recombining genes into
hybrid molecules that can be inserted into living organisms. Prototype drugs are the first
drug of a particular group to be developed.
PTS: 1 REF: p. 3, Drug Sources OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
3. Which classification applies to morphine?
A. Central nervous system depressant
B. Central nervous system stimulant
C. Anti-inflammatory
D. Antihypertensive
ANS: A
Rationale: Drugs are classified according to their effects on particular body systems, their
therapeutic uses, and their chemical characteristics. Morphine is classified as a central
nervous system depressant and will produce this effect in the client. A central nervous
, system stimulant increases attention and raises mood. An anti-inflammatory agent decreases
inflammation at the site of tissue or joint inflammation. An antihypertensive agent reduces
blood pressure.
PTS: 1 REF: p. 3, Drug Classifications and Prototypes
OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Remember NOT: Multiple Choice
4. A client is administered amoxicillin. The generic name of this medication belongs to which
drug group?
A. Selective serotonin reuptake inhibitors
B. Diuretics
C. Penicillins
D. ACE inhibitors
ANS: C
Rationale: The generic name often indicates the drug group (e.g., drugs with generic names
ending in “cillin” are penicillins). Selective serotonin reuptake inhibitors are medications
that have antidepressant effects; SSRI is a broad classification, not a generic name. Diuretics
are medications that increase urine output; diuretic is a broad classification, not a generic
name. ACE inhibitor is the broad classification for the angiotensin receptor blockers, not the
generic name.
PTS: 1 REF: p. 3, Drug Names OBJ: 2
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
5. The administration of diphenhydramine is regulated by which U.S. government agency?
A. Public Health Service
B. Federal Trade Commission
C. Occupational Safety and Health Administration
D. Food and Drug Administration
ANS: D
Rationale: The Food and Drug Administration approves drugs for over-the-counter
availability, including the transfer of drugs from prescription to OTC status, and may
require clinical trials to determine the safety and effectiveness of OTC use. The Public
Health Service is regulated by the state to maintain the health of individual citizens of the
state. The Federal Trade Commission regulates imports and exports throughout the nation.
The Occupational Safety and Health Administration regulates safety within the workplace.
PTS: 1 REF: p. 4, Prescription and Nonprescription Drugs
OBJ: 4
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
6. In the U.S., the administration of anabolic steroids is regulated by which law?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Comprehensive Drug Abuse Prevention and Control Act
, C. The Harrison Narcotic Act
D. The Sherley Amendment
ANS: B
Rationale: The Comprehensive Drug Abuse Prevention and Control Act regulates the
manufacture and distribution of narcotics, stimulants, depressants, hallucinogens, and
anabolic steroids. The Food, Drug, and Cosmetic Act of 1938 revised and broadened FDA
powers and responsibilities, giving the FDA control over drug safety. The Harrison Narcotic
Act restricted the importation, manufacture, sale, and use of opium, cocaine, marijuana, and
other drugs that the act defined as narcotics. The Sherley Amendment of 1912 prohibited
fraudulent claims of drug effectiveness.
PTS: 1 REF: p. 4, Prescription and Nonprescription Drugs
OBJ: 3
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Remember NOT: Multiple Choice
7. A nurse is responsible for maintaining an accurate count and record of the controlled
substances on the nursing division. This nursing action is regulated by which U.S. law or
agency?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Public Health Service
C. The Drug Enforcement Administration
D. The Sherley Amendment
ANS: C
Rationale: The Drug Enforcement Administration enforces the Controlled Substances Act.
Under this enforcement, nurses are responsible for storing controlled substances in locked
containers, administering them only to the people for whom they are prescribed, recording
each dose given, and maintaining an accurate inventory. The Food, Drug, and Cosmetic Act
of 1938 revised and broadened FDA powers and responsibilities, giving the FDA control
over drug safety. The Public Health Service is regulated by the state to maintain the health
of individual citizens of the state. The Sherley Amendment of 1912 prohibited fraudulent
claims of drug effectiveness.
PTS: 1 REF: p. 7, Testing Procedure OBJ: 4
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
8. In Phase 1 clinical trials, the potential uses and effects of a new drug are determined by
which method?
A. Administering doses to healthy volunteers
B. Administering doses to people with the disease
C. Administering in placebo-controlled design
D. Calculating the risk-to-benefit ratio
ANS: A
Rationale: Phase 1 studies allow for the administration of the medication to healthy
volunteers to determine safe dosages, routes of administration, absorption, metabolism,
excretion, and toxicity. In Phase 2 studies, a few doses are given to a certain number of
subjects with the disease or symptom for which the drug is being studied and responses are
compared with those of healthy subjects. Placebo-controlled designs are used in Phase 3
ABRAMS’ CLINICAL DRUG THERAPY RATIONALES FOR NURSING
PRACTICE 12TH EDITION
GERALYN FRANDSEN
,Chapter 1, The Foundation of Pharmacology: Quality and Safety
1. A woman diagnosed with obsessive–compulsive disorder has been prescribed oral
paroxetine hydrochloride. What is the expected effect for this prescription?
A. Curative effect on symptoms
B. Systemic effect on symptoms
C. Local effect on symptoms
D. Parenteral effect on symptoms
ANS: B
Rationale: Drugs that produce systemic effects are taken into the body, circulated through
the bloodstream to their sites of action in various body tissues, and eventually eliminated
from the body. Curative agents are given to cure a disease process. In this case, paroxetine
hydrochloride will control the symptoms but not cure the disorder. Drugs with local effects,
such as sunscreen and local anesthetics, act mainly at the site of application. Paroxetine
hydrochloride is not administered parenterally. Parenteral agents are administered
subcutaneously, intramuscularly, or intravenously.
PTS: 1 REF: p. 3, Introduction OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
2. A client has been prescribed an antibiotic. This medication is a naturally occurring
substance that has been chemically modified. What is another name for this type of
medication?
A. Synthetic drug
B. Semisynthetic drug
C. Biotechnology drug
D. Prototype drug
ANS: B
Rationale: Semisynthetic drugs (e.g., many antibiotics) are naturally occurring substances
that have been chemically modified. Synthetic drugs are more standardized in their chemical
characteristics, more consistent in their effects, and less likely to produce allergic reactions.
Biotechnology drugs involve manipulating DNA and RNA and recombining genes into
hybrid molecules that can be inserted into living organisms. Prototype drugs are the first
drug of a particular group to be developed.
PTS: 1 REF: p. 3, Drug Sources OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
3. Which classification applies to morphine?
A. Central nervous system depressant
B. Central nervous system stimulant
C. Anti-inflammatory
D. Antihypertensive
ANS: A
Rationale: Drugs are classified according to their effects on particular body systems, their
therapeutic uses, and their chemical characteristics. Morphine is classified as a central
nervous system depressant and will produce this effect in the client. A central nervous
, system stimulant increases attention and raises mood. An anti-inflammatory agent decreases
inflammation at the site of tissue or joint inflammation. An antihypertensive agent reduces
blood pressure.
PTS: 1 REF: p. 3, Drug Classifications and Prototypes
OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Remember NOT: Multiple Choice
4. A client is administered amoxicillin. The generic name of this medication belongs to which
drug group?
A. Selective serotonin reuptake inhibitors
B. Diuretics
C. Penicillins
D. ACE inhibitors
ANS: C
Rationale: The generic name often indicates the drug group (e.g., drugs with generic names
ending in “cillin” are penicillins). Selective serotonin reuptake inhibitors are medications
that have antidepressant effects; SSRI is a broad classification, not a generic name. Diuretics
are medications that increase urine output; diuretic is a broad classification, not a generic
name. ACE inhibitor is the broad classification for the angiotensin receptor blockers, not the
generic name.
PTS: 1 REF: p. 3, Drug Names OBJ: 2
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
5. The administration of diphenhydramine is regulated by which U.S. government agency?
A. Public Health Service
B. Federal Trade Commission
C. Occupational Safety and Health Administration
D. Food and Drug Administration
ANS: D
Rationale: The Food and Drug Administration approves drugs for over-the-counter
availability, including the transfer of drugs from prescription to OTC status, and may
require clinical trials to determine the safety and effectiveness of OTC use. The Public
Health Service is regulated by the state to maintain the health of individual citizens of the
state. The Federal Trade Commission regulates imports and exports throughout the nation.
The Occupational Safety and Health Administration regulates safety within the workplace.
PTS: 1 REF: p. 4, Prescription and Nonprescription Drugs
OBJ: 4
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
6. In the U.S., the administration of anabolic steroids is regulated by which law?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Comprehensive Drug Abuse Prevention and Control Act
, C. The Harrison Narcotic Act
D. The Sherley Amendment
ANS: B
Rationale: The Comprehensive Drug Abuse Prevention and Control Act regulates the
manufacture and distribution of narcotics, stimulants, depressants, hallucinogens, and
anabolic steroids. The Food, Drug, and Cosmetic Act of 1938 revised and broadened FDA
powers and responsibilities, giving the FDA control over drug safety. The Harrison Narcotic
Act restricted the importation, manufacture, sale, and use of opium, cocaine, marijuana, and
other drugs that the act defined as narcotics. The Sherley Amendment of 1912 prohibited
fraudulent claims of drug effectiveness.
PTS: 1 REF: p. 4, Prescription and Nonprescription Drugs
OBJ: 3
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Remember NOT: Multiple Choice
7. A nurse is responsible for maintaining an accurate count and record of the controlled
substances on the nursing division. This nursing action is regulated by which U.S. law or
agency?
A. The Food, Drug, and Cosmetic Act of 1938
B. The Public Health Service
C. The Drug Enforcement Administration
D. The Sherley Amendment
ANS: C
Rationale: The Drug Enforcement Administration enforces the Controlled Substances Act.
Under this enforcement, nurses are responsible for storing controlled substances in locked
containers, administering them only to the people for whom they are prescribed, recording
each dose given, and maintaining an accurate inventory. The Food, Drug, and Cosmetic Act
of 1938 revised and broadened FDA powers and responsibilities, giving the FDA control
over drug safety. The Public Health Service is regulated by the state to maintain the health
of individual citizens of the state. The Sherley Amendment of 1912 prohibited fraudulent
claims of drug effectiveness.
PTS: 1 REF: p. 7, Testing Procedure OBJ: 4
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integrated Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
8. In Phase 1 clinical trials, the potential uses and effects of a new drug are determined by
which method?
A. Administering doses to healthy volunteers
B. Administering doses to people with the disease
C. Administering in placebo-controlled design
D. Calculating the risk-to-benefit ratio
ANS: A
Rationale: Phase 1 studies allow for the administration of the medication to healthy
volunteers to determine safe dosages, routes of administration, absorption, metabolism,
excretion, and toxicity. In Phase 2 studies, a few doses are given to a certain number of
subjects with the disease or symptom for which the drug is being studied and responses are
compared with those of healthy subjects. Placebo-controlled designs are used in Phase 3
