investigati
on of
Typhoid
Fever
, 1)Culture
A) Blood culture
• Results of blood cultures are positive in 40-60% of the patients seen early in the course of the
disease
• However, the sensitivity of blood cultures in diagnosing typhoid fever in many parts of the
developing world is limited because widespread liberal antibiotic use may render bacteriologic
confirmation difficult.
B) Stool & urine culture
• Stool and urine culture results become positive after the 1st week
• The stool culture result is also occasionally positive during the incubation period.
C) Bone marrow culture
• Although bone marrow cultures may increase the likelihood of bacteriologic confirmation of
typhoid, collection of the specimens is difficult and relatively invasive.