White Blood Cell Disorder Study Guide 2023 with
complete solution
The production of RBCs and WBCs occurs in the
bone marrow
The maturation of T-cells occurs in the
thymus
Which of the following areas in a secondary lymphoid organ allows antigens in the blood
to come into contact with lymphocytes?
white pulp of the spleen
What are the cells of the myeloid lineage?
neutrophils (PMNs)
eosinophils
basophils
monocytes
mast cells
RBCs
platelets
What are the cells of the lymphoid lineage?
B-cells
T-cells
NK cells
plasma cells
What is the normal absolute value of neutrophils? What percentage of WBC do they
constitute?
1,800-8,500/uL
40-74%
Lymphadenopathy and splenomaegaly are examples of ____________________ of
lymphoid tissues
hyperplasia
Hyperplasia of granulocytes is called _____________, which is accompanied by
_____________ since they make the majority of granulocytes
granulocytosis
neutrophilia
Two ways to differentiate between hyperplasia and neoplasia (usually)?
1) hyperplasia usually reversible w/ removal of stimulus
2) hyperplastic cells are well-differentiated (neoplasias usually are less differentiated)
What two WBCs are hyperplastic in parasitic infections and allergies?
eosinophils (eosinophilia)
mast cells (mastocytosis)
Bacterial infections, burns, and large areas of necrosis cause hyperplasia of
, neutrophils (granulocytosis)
What granulocyte is hyperplastic in myeloproliferative disease?
basophils (basophilia)
Chronic infections are accompanied with hyperplasia of what WBCs?
monocytes (monocytosis)
lymphocytes (lymphocytosis)
Viral infections cause hyperplasia of what WBCs
lymphocytes (lymphocytosis)
T/F: Lymphadenopathy is inflammation of the lymph nodes
False; enlargement (inflammation is called lymphadenitis)
What MALT can be found in the oral cavity?
tonsils (Waldeyer ring)
6 clues that lymphadenopathy is reactive and not neoplastic?
- symptomatic/pain
- S&S of regional infection
- smaller (less than 2 cm)
- transient, if reaction is acute
- 4 signs of inflammation
- responds to antibiotics
T/F: Acute & chronic inflammation can cause lymphoid hyperplasia
True
A neutrophil count below ________________ constitutes neutropenia
If it is below ______________ then it is agranulocytosis
1500/uL or less
200/uL
3 most common causes for neutropenia
infections
drugs
radiation
African American male gets a CBC count with low numbers of neutrophils (1200/uL). Pt
shows NO clinical symptoms.
What is the likely dx?
benign ethnic neutropenia
What do ulcers look like in the oral cavity of a pt w/ neutropenia?
complete solution
The production of RBCs and WBCs occurs in the
bone marrow
The maturation of T-cells occurs in the
thymus
Which of the following areas in a secondary lymphoid organ allows antigens in the blood
to come into contact with lymphocytes?
white pulp of the spleen
What are the cells of the myeloid lineage?
neutrophils (PMNs)
eosinophils
basophils
monocytes
mast cells
RBCs
platelets
What are the cells of the lymphoid lineage?
B-cells
T-cells
NK cells
plasma cells
What is the normal absolute value of neutrophils? What percentage of WBC do they
constitute?
1,800-8,500/uL
40-74%
Lymphadenopathy and splenomaegaly are examples of ____________________ of
lymphoid tissues
hyperplasia
Hyperplasia of granulocytes is called _____________, which is accompanied by
_____________ since they make the majority of granulocytes
granulocytosis
neutrophilia
Two ways to differentiate between hyperplasia and neoplasia (usually)?
1) hyperplasia usually reversible w/ removal of stimulus
2) hyperplastic cells are well-differentiated (neoplasias usually are less differentiated)
What two WBCs are hyperplastic in parasitic infections and allergies?
eosinophils (eosinophilia)
mast cells (mastocytosis)
Bacterial infections, burns, and large areas of necrosis cause hyperplasia of
, neutrophils (granulocytosis)
What granulocyte is hyperplastic in myeloproliferative disease?
basophils (basophilia)
Chronic infections are accompanied with hyperplasia of what WBCs?
monocytes (monocytosis)
lymphocytes (lymphocytosis)
Viral infections cause hyperplasia of what WBCs
lymphocytes (lymphocytosis)
T/F: Lymphadenopathy is inflammation of the lymph nodes
False; enlargement (inflammation is called lymphadenitis)
What MALT can be found in the oral cavity?
tonsils (Waldeyer ring)
6 clues that lymphadenopathy is reactive and not neoplastic?
- symptomatic/pain
- S&S of regional infection
- smaller (less than 2 cm)
- transient, if reaction is acute
- 4 signs of inflammation
- responds to antibiotics
T/F: Acute & chronic inflammation can cause lymphoid hyperplasia
True
A neutrophil count below ________________ constitutes neutropenia
If it is below ______________ then it is agranulocytosis
1500/uL or less
200/uL
3 most common causes for neutropenia
infections
drugs
radiation
African American male gets a CBC count with low numbers of neutrophils (1200/uL). Pt
shows NO clinical symptoms.
What is the likely dx?
benign ethnic neutropenia
What do ulcers look like in the oral cavity of a pt w/ neutropenia?
