NR566 Final (Advanced Pharmacology for Care of the Family
1. Anti-Androgens: Finasteride
(Propecia) Leuprolide (Eligard,
Lupron, Lupron Depot)
Spironolactone (Aldactone)
2. Finasteride (Propecia, Proscar): blocks conversion of
testosterone to dihydro- testerone
Used to tx:
-BPH
-male pattern baldness
3 months of therapy need to see
benefits Stopping, reverses effect
w/in 12 months
Adverse side effects:
- Decreased libido
-Impotence
3. dutasteride (Avodart): 5-alpha
reductase inhibitor used to tx:
BPH
Can stay in serum up to 6 mon after
discontinuing can be absorbed through skin
pregnant woman shouldn't handle
capsules (fetal anomaly in male
fetus)
Adverse
Effects
decreased
libido
Impotence
4. Leuprolide Acetate (Lupron): Luteinizing hormone
- releasing agonist create reversible:
-orchiectomy state
,-oophorectomy state
Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
, - polycystic ovarian disease
- central precocious puberty in peds
5. Flutamide (Eulexin, Euflex): Truly
non-steroidal agent Used to tx:
-Advanced prostate cancer
-female androgen excess syndrome
Adverse Effects in males
- gynecomastia
-reversible liver toxicity
Black Box Warning
-hepatic failure
-hepatic encephalopathy
Basline/monthly liver function test for 1st 4 months
6. Spironolactone (Aldactone):
aldosterone antagonist potassium sparing
diuretic
used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d)
Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
- Urticaria
Black Box Warning
Tumorigenicity in
animals
Should not be used during pregnancy
7. Androgen: Testosterone
1. Anti-Androgens: Finasteride
(Propecia) Leuprolide (Eligard,
Lupron, Lupron Depot)
Spironolactone (Aldactone)
2. Finasteride (Propecia, Proscar): blocks conversion of
testosterone to dihydro- testerone
Used to tx:
-BPH
-male pattern baldness
3 months of therapy need to see
benefits Stopping, reverses effect
w/in 12 months
Adverse side effects:
- Decreased libido
-Impotence
3. dutasteride (Avodart): 5-alpha
reductase inhibitor used to tx:
BPH
Can stay in serum up to 6 mon after
discontinuing can be absorbed through skin
pregnant woman shouldn't handle
capsules (fetal anomaly in male
fetus)
Adverse
Effects
decreased
libido
Impotence
4. Leuprolide Acetate (Lupron): Luteinizing hormone
- releasing agonist create reversible:
-orchiectomy state
,-oophorectomy state
Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
, - polycystic ovarian disease
- central precocious puberty in peds
5. Flutamide (Eulexin, Euflex): Truly
non-steroidal agent Used to tx:
-Advanced prostate cancer
-female androgen excess syndrome
Adverse Effects in males
- gynecomastia
-reversible liver toxicity
Black Box Warning
-hepatic failure
-hepatic encephalopathy
Basline/monthly liver function test for 1st 4 months
6. Spironolactone (Aldactone):
aldosterone antagonist potassium sparing
diuretic
used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d)
Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
- Urticaria
Black Box Warning
Tumorigenicity in
animals
Should not be used during pregnancy
7. Androgen: Testosterone
