Dispensing and Adverse Drug Reactions Questions and Answers 2023 with complete solution

Dispensing and Adverse Drug Reactions Questions and
Answers 2023 with complete solution
Drugs bound to plasma proteins are considered:
A. Pharmacologically active
B. Pharmacologically inactive
C. Free drugs
B. Bioavailable drugs
B. Pharmacologically inactive
Alkaline salts like Potassium penicillin when placed in an acidic solution can result in:
A. conversion into free acid
B. precipitation of penicillin
C. insolubility
D. all of the above
D. all of the above
In metabolizing a standard dose of INH, Filipinos are considered:
A. fast acetylators
B. slow acetylators
C. neither slow or fast
D. same as the Caucasians
A. fast acetylators
The following are true regarding incompatibilities except:
A. problems arising during compounding, dispensing and drug administration
B. easier to correct than to prevent
C. maybe intentional or unintentional
D. must be recognized by pharmacist
B. easier to correct than to prevent
The following are guidelines for reducing drug interactions except:
A. employ combination therapy
B. identify patient risk factors
C. educate the patient
D. know properties of drugs
A. employ combination therapy
Enzyme inhibition of coumarin can lead to:
A. hypoglycemia
B. profuse bleeding
C. blood clotting
D. convulsion
B. profuse bleeding
Anaphylaxis is a:
A. type A ADR
B. type B ADR
C. type E ADR
D. type F ADR
B. type B ADR

,Oxidizing agents are incompatible with reducing agents. This is a:
A. physical incompatibility
B. therapeutic incompatibility
C. chemical incompatibility
D. both a and b
C. chemical incompatibility
The following are manifestations of chemical incompatibilities, except:
A. immiscibility
B. photolysis
C. gel formation
D. evolution of gas
A. immiscibility
Teratogenicity is a/an:
A. type A ADR
B. type B ADR
C. type C ADR
D. type D ADR
D. type D ADR
Any drug reaction which does not necessarily have casual relationship with the
treatment is called an:
A. adverse drug reaction
B. therapeutic incompatibility
C. adverse drug event
D. none of the above
C. adverse drug event
The precipitation of organic substance from a saturated solution when highly soluble
salts are added is known as:
A. Polymorphism
B. salting dash out
C. racemization
D. eutexia
B. salting dash out
Acacia in the presence of Bismuth salts can form a "cake" at the bottom of the
container. This manifestation is known as:
A. gelatinization
B. hydrolysis
C. emulsification
D. cementation
D. cementation
Sudden withdrawal of steroids can result in:
A. anemia
B. hypertension
C. Parkinson's disease
D. Addison's disease
D. Addison's disease

,A mathematical model for potentiating drug effect:
A. 1+1=2
B. 1+1=3
C. 0+1=2
D. 1+1=0
C. 0+1=2
A remedy for tablet granulations containing vitamin C:
A. prepare by dry granulation
B. used pre-coated ascorbic acid granules
C. both a&b
D. none
C. both a&b
Chloramphenicol palmitate exist in 3 different polymorphs, each differ in the following
properties except:
A. solubility
B. free energy
C. melting point
D. none of the above
D. none of the above
The following are the physiologic effects of food on drug action except:
A. reduces gastric emptying rate
B. milk reduces absorption of tetracycline
C. tea increases absorption of paracetamol
D. vegetables potentiate anticoagulants
D. vegetables potentiate anticoagulants
Important characteristics of idiosyncratic drug reactions, except:
A. congenital hypersensitivities
B. genetic or hereditary in origin
C. metabolic abnormality
D. none of the above
D. none of the above
Monoamine oxidase inhibitors (MAOI) and foods rich in tyramine like cheese will lead to:
A. accumulation of pressor amines
B. increase in blood pressure
C. non-metabolism of tyramine
D. all of the above
D. all of the above
The following condition/s will amplify the activity of cardiac glycosides:
A. hypercalcemia
B. hypokalemia
C. both a&b
D. none of the above
C. both a&b
Drug-drug interactions that occur when one drug alters the absorption, distribution,
metabolism and excretion of the other drug:
A. pharmacokinetic interactions

, B. pharmacologic interactions
C. pharmacodynamic interactions
D. all of the above
A. pharmacokinetic interactions
Displacement of plasma-protein bound drug such as in Warfarin phenylbutazone
interactions results in:
A. hemorrhage
B. increased concentration of Warfarin
C. decreased activity of Warfarin
D. all
D. all
Tobacco and cigarettes are potent enzyme inducers. As a consequence:
A. one needs to increase dose of drug
B. this leads to drug tolerance
C. this is an ADR
D. all
D. all
A drug-induced hypersensitivity reaction caused by sulfonamides:
A. Parkinson's disease
B. Steven-Johnson's syndrome
C. hypertension
D. contact dermatitis
B. Steven-Johnson's syndrome
The following are true regarding excretion of acidic drugs except:
A. exist in the ionized state in alkaline urine
B. exist in the non-ionized form in acidic urine
C. acidic urine increases drug action
D. none of the above
D. none of the above
Phenobarbital and griseofulvine are ___________ of coumarin:
A. enzyme inducers
B. enzyme inhibitor
C. antagonists
D. agonists
A. enzyme inducers
Type F ADRs can occur as a result of the following except:
A. antimicrobial drug resistance
B. patient compliance
C. counterfeit drugs
D. drug instability
B. patient compliance
Chloramphenicol can lead to this untoward drug reaction:
A. agranulocytosis
B. Gray syndrome
C. both a&b
D. none of the above