Lab report
Abstract: Experiments performed to investigate neurotransmission at the neuromuscular junction.
Acknowledgement: In order to obtain the data for this experiment # collected the data as labpartner.
Introduction: Drugs affecting cholinergic neurotransmission can be divided into drugs that act directly and
drugs that act indirectly. The direct acting binds to the muscarinic receptors (M1,M2,M3,M4 or N) and activates
it (agonistic). While the indirect acting drugs increase the levels/availability of ACh by different target actions.
Another way to categorize the drugs are drugs that causes depolarization and drugs that do not cause
depolarization (non-depolarizing drugs).
Figure of the cholinergic neurotransmission from: Wilkinson, David & Francis, Paul & Schwam, Elias & Payne-Parrish,
Jennifer. (2004). Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between
pharmacological effects and clinical efficacy. Drugs & aging. 21. 453-78.
Illustration depicting the synthesis, degradation and actions of acetylcholine (ACh) on target receptors.
1
Abstract: Experiments performed to investigate neurotransmission at the neuromuscular junction.
Acknowledgement: In order to obtain the data for this experiment # collected the data as labpartner.
Introduction: Drugs affecting cholinergic neurotransmission can be divided into drugs that act directly and
drugs that act indirectly. The direct acting binds to the muscarinic receptors (M1,M2,M3,M4 or N) and activates
it (agonistic). While the indirect acting drugs increase the levels/availability of ACh by different target actions.
Another way to categorize the drugs are drugs that causes depolarization and drugs that do not cause
depolarization (non-depolarizing drugs).
Figure of the cholinergic neurotransmission from: Wilkinson, David & Francis, Paul & Schwam, Elias & Payne-Parrish,
Jennifer. (2004). Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between
pharmacological effects and clinical efficacy. Drugs & aging. 21. 453-78.
Illustration depicting the synthesis, degradation and actions of acetylcholine (ACh) on target receptors.
1
