NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
57 year old man - radiation therapy for squamous cell carcinoma of the lung.
Despite therapy, tumor increases in size and he dies 6 months later. The
progressive tumor growth is due to a defect in cell cycle arrest in which of the
following phases of cell cycle? -Answer= G1
28 year old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 -
imaging shows bilateral hydroureter and hydronephrosis. Biopsy shows marked
fibrosis and scattered granulomas. DX? -Answer= Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and
man has two gene deletion. If the two gene is trans - what percentage of offspring
will have a two gene deletion?
-Answer= 50%
previously healthy 40 year brought to emergency department by her husband -
2 day history of fever, lethargy, confusion. PE shows scattered petechiae and
ecchymoses over the lower extremities - 3+ polychromasia and 3+ schistocytes
and Low platelets Dx? -Answer= Thrombotic Thrombocytopenia Purpura
16 year old boy - is admitted to the ER because of a knife wound to the left side
of his chest. An X- ray of the chest shows an air-fluid level in the left side of the
chest, partial collapse of the left lung, and the elevation of the stomach bubble.
The mediastinum is midline. DX? -Answer= Hemopneumpothorax under tension
49 year old woman - coronary artery disease - BP 140/90 - High Cholesterol, High
LDL (190), High triglycerides (350) - TX with atorvastatin and losartan. What are
the effects on HDL and Triglycerides? -Answer= HDL increased
Triglycerides Decreased
73 yeare old - diffuse weakness and tingling of her arms and legs. Sensation and
vibration and position is decreased in all extremities. What vitamin deficiency? -
Answer= Vitamin B12 - (cyanocobalamin)
Tea and Toast - low B12 in diet
15 year old girl - 3 month history of acne - which is the underlying cause of the
patients acne? -
Answer= Stimulation of Sebaceous Glands by
androgens b. ACNE = Propionibacterium ACNE
4 year old from Brazil - PE shows single 12x10cm lesion in the right side of jaw
with diffuse regular edges. Photomicrographs of an incisional biopsy (looks like
Burkitts Lymphoma/ Starry night) - which of the processes most likely to occur in
the region indicated by the arrow? -Answer=
Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion,
puffy face).
,NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
51 year old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass
on apex of tongue. It is most appropriate to evaluate which lymph nodes first for
evidence of metastasis? -Answer= Submental
15 year old boy - ER - 2 hour history of confusion and agitation - fever, headache,
stiff neck, and vomiting - since returned from summer camp - patient is
hallucinating - lumbar puncture - shows cysts and trophozoites- most likely
pathogen? -Answer= a. Olfactory Nerve
Naegleria fowleri
17 year old - ED - 30 minutes after being found with a blank stare. Physical exam
shows rigidity. During exam he becomes hostile and assaults physician - Pt
ingested which drug? -Answer= PCP
Placebo controlled clinical trial - 5000 pts with essential hypertension. 2500
patients receive new drug and 2500 patients receive placebo. If alpha is set at
0.01 instead of 0.05, which of the following is most likely result? -Answer=
Significant findings can be reported with greater confidence
17 year old - gymnast - comes to hospital because of lack of menstrual period for
6 months. BMI 15 Which is the cause of the amenorrhea? -Answer=
Hypogonadotropic Hypogonadism
A male stillborn is delivered at 32 weeks - Oligohydramnios - absence of a urethral
opening. Which is most likely finding? -Answer= Pulmonary Hypoplasia
A 6 day old - breast fed boy in ED - poor weight gain and irritability since delivery
- Physical exam shows jaundice and hepatomegaly. The concentration of which of
the following metabolites is most likely increased? -Answer= a. Galactose - 1 -
phosphate
b. Congenital intolerance to breast milk
A 25-year-old man - comes to ED - severe muscle pain, diffuse, painful
swelling of his neck, underarms, and groin after camping in New Mexico
Generalized scattered black maculae.
Examination of the right upper extremity shows erythematous, solid, tender mass.
Mass is draining blood and necrotic material. The most effective antibiotic for
patient disorder will interfere with which of the following processes? -Answer= a.
Ribosomal Assembly
b. Yersenia Pestis
45 year old - progressive weakness - muscle fasciculations of the upper extremities
and weakness of the lower extremity - What additional findings? -Answer= Atrophy
b. ALS = Lou Gherig
A new severe respiratory illness - Why use a killed vaccine vs a live vaccine? -
Answer= Avoids Concerns of reversion to virulence
b. Killed vaccines - avoids reversion to virulence
c. live vaccines - can (but rarely do) cause the disease they're designed to prevent
,NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
A 33 year old - keratinizing squamous cell carcinoma of cervix. Which of the
following describes pathogenesis of this patient's disease? -Answer= Inactivation of
Cellular P53
b. p53 protein = tumor suppressor (it activates apoptosis) - most human cancer
A 54 year old - 40 year history of T1DM - receiving hemodialysis for end stage
renal disease while awaiting a kidney transplant. Receives a drug that induces
reticulocyte release from bone marrow and stimulates a cytokine receptor that
signals Jak/Stat pathway? -Answer= Erythropoietin
Jak Stat - erythropoietin
During a clinical study examining the effects of exercise. The average pulse is
175/min. Compared with measurement before the session, which is most likely
decreased? -Answer= Total Peripheral Resistance
An 8-year-old boy - 3-day history of fever, sore throat, and itchy eyes. Returned
from week long summer camp that includes hiking trips and swimming - PE shows
conjunctival injection and oropharyngeal edema - Outbreak among other campers.
Which is most likely cause of this patient's symptoms? -Answer= Adenovirus
Fever+ Sore Throat + Itchy
Eyes transmitted via
swimming pools
Conjunctivitis Viral =
adenovirus
44-year-old woman - 10 month history of wide red streaks over her lower trunk
(striae) and weight gain in face (moonface). Which additional findings? -Answer=
Hypertension and muscle weakness b. Cushing - hypertension and muscle
weakness
12 year old boy - pain below left knee -unable to play soccer - An x-ray shown -
Which structures attached to the abnormal anterior tibial area? -Answer= patellar
ligament
b. Osgood-Schlatter
A 65-year-old health maintenance exams - He lives is a single-family home with
his cat and dog. He spend much of his time in his basement woodworking shop.
This patient is increased risk for lung cancer due to which of the following
environmental exposures? -Answer= Radon
54- year-old man - intense overwhelming fear. Which portion of brain stimulated? -
Answer=
Amygdala
b. Fear = amygdala
30 year old woman - recurrent URI - Sweat is Salty- Genetic testing for 36 most
common mutations shows detectable G551D in one allele of CFTR - What is patients
clinical phenotype? -Answer= The Second CFTR Gene was not detected by the
testing obtained
, NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
74 year old - COPD - "I enjoy coming to see you because you remind me of my
daughter. She died 35 years ago". Which is most appropriate response by physician?
-Answer= You must miss your daughter very much. Tell me about her.
ANSWERS 2022 UPDATE
57 year old man - radiation therapy for squamous cell carcinoma of the lung.
Despite therapy, tumor increases in size and he dies 6 months later. The
progressive tumor growth is due to a defect in cell cycle arrest in which of the
following phases of cell cycle? -Answer= G1
28 year old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 -
imaging shows bilateral hydroureter and hydronephrosis. Biopsy shows marked
fibrosis and scattered granulomas. DX? -Answer= Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and
man has two gene deletion. If the two gene is trans - what percentage of offspring
will have a two gene deletion?
-Answer= 50%
previously healthy 40 year brought to emergency department by her husband -
2 day history of fever, lethargy, confusion. PE shows scattered petechiae and
ecchymoses over the lower extremities - 3+ polychromasia and 3+ schistocytes
and Low platelets Dx? -Answer= Thrombotic Thrombocytopenia Purpura
16 year old boy - is admitted to the ER because of a knife wound to the left side
of his chest. An X- ray of the chest shows an air-fluid level in the left side of the
chest, partial collapse of the left lung, and the elevation of the stomach bubble.
The mediastinum is midline. DX? -Answer= Hemopneumpothorax under tension
49 year old woman - coronary artery disease - BP 140/90 - High Cholesterol, High
LDL (190), High triglycerides (350) - TX with atorvastatin and losartan. What are
the effects on HDL and Triglycerides? -Answer= HDL increased
Triglycerides Decreased
73 yeare old - diffuse weakness and tingling of her arms and legs. Sensation and
vibration and position is decreased in all extremities. What vitamin deficiency? -
Answer= Vitamin B12 - (cyanocobalamin)
Tea and Toast - low B12 in diet
15 year old girl - 3 month history of acne - which is the underlying cause of the
patients acne? -
Answer= Stimulation of Sebaceous Glands by
androgens b. ACNE = Propionibacterium ACNE
4 year old from Brazil - PE shows single 12x10cm lesion in the right side of jaw
with diffuse regular edges. Photomicrographs of an incisional biopsy (looks like
Burkitts Lymphoma/ Starry night) - which of the processes most likely to occur in
the region indicated by the arrow? -Answer=
Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion,
puffy face).
,NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
51 year old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass
on apex of tongue. It is most appropriate to evaluate which lymph nodes first for
evidence of metastasis? -Answer= Submental
15 year old boy - ER - 2 hour history of confusion and agitation - fever, headache,
stiff neck, and vomiting - since returned from summer camp - patient is
hallucinating - lumbar puncture - shows cysts and trophozoites- most likely
pathogen? -Answer= a. Olfactory Nerve
Naegleria fowleri
17 year old - ED - 30 minutes after being found with a blank stare. Physical exam
shows rigidity. During exam he becomes hostile and assaults physician - Pt
ingested which drug? -Answer= PCP
Placebo controlled clinical trial - 5000 pts with essential hypertension. 2500
patients receive new drug and 2500 patients receive placebo. If alpha is set at
0.01 instead of 0.05, which of the following is most likely result? -Answer=
Significant findings can be reported with greater confidence
17 year old - gymnast - comes to hospital because of lack of menstrual period for
6 months. BMI 15 Which is the cause of the amenorrhea? -Answer=
Hypogonadotropic Hypogonadism
A male stillborn is delivered at 32 weeks - Oligohydramnios - absence of a urethral
opening. Which is most likely finding? -Answer= Pulmonary Hypoplasia
A 6 day old - breast fed boy in ED - poor weight gain and irritability since delivery
- Physical exam shows jaundice and hepatomegaly. The concentration of which of
the following metabolites is most likely increased? -Answer= a. Galactose - 1 -
phosphate
b. Congenital intolerance to breast milk
A 25-year-old man - comes to ED - severe muscle pain, diffuse, painful
swelling of his neck, underarms, and groin after camping in New Mexico
Generalized scattered black maculae.
Examination of the right upper extremity shows erythematous, solid, tender mass.
Mass is draining blood and necrotic material. The most effective antibiotic for
patient disorder will interfere with which of the following processes? -Answer= a.
Ribosomal Assembly
b. Yersenia Pestis
45 year old - progressive weakness - muscle fasciculations of the upper extremities
and weakness of the lower extremity - What additional findings? -Answer= Atrophy
b. ALS = Lou Gherig
A new severe respiratory illness - Why use a killed vaccine vs a live vaccine? -
Answer= Avoids Concerns of reversion to virulence
b. Killed vaccines - avoids reversion to virulence
c. live vaccines - can (but rarely do) cause the disease they're designed to prevent
,NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
A 33 year old - keratinizing squamous cell carcinoma of cervix. Which of the
following describes pathogenesis of this patient's disease? -Answer= Inactivation of
Cellular P53
b. p53 protein = tumor suppressor (it activates apoptosis) - most human cancer
A 54 year old - 40 year history of T1DM - receiving hemodialysis for end stage
renal disease while awaiting a kidney transplant. Receives a drug that induces
reticulocyte release from bone marrow and stimulates a cytokine receptor that
signals Jak/Stat pathway? -Answer= Erythropoietin
Jak Stat - erythropoietin
During a clinical study examining the effects of exercise. The average pulse is
175/min. Compared with measurement before the session, which is most likely
decreased? -Answer= Total Peripheral Resistance
An 8-year-old boy - 3-day history of fever, sore throat, and itchy eyes. Returned
from week long summer camp that includes hiking trips and swimming - PE shows
conjunctival injection and oropharyngeal edema - Outbreak among other campers.
Which is most likely cause of this patient's symptoms? -Answer= Adenovirus
Fever+ Sore Throat + Itchy
Eyes transmitted via
swimming pools
Conjunctivitis Viral =
adenovirus
44-year-old woman - 10 month history of wide red streaks over her lower trunk
(striae) and weight gain in face (moonface). Which additional findings? -Answer=
Hypertension and muscle weakness b. Cushing - hypertension and muscle
weakness
12 year old boy - pain below left knee -unable to play soccer - An x-ray shown -
Which structures attached to the abnormal anterior tibial area? -Answer= patellar
ligament
b. Osgood-Schlatter
A 65-year-old health maintenance exams - He lives is a single-family home with
his cat and dog. He spend much of his time in his basement woodworking shop.
This patient is increased risk for lung cancer due to which of the following
environmental exposures? -Answer= Radon
54- year-old man - intense overwhelming fear. Which portion of brain stimulated? -
Answer=
Amygdala
b. Fear = amygdala
30 year old woman - recurrent URI - Sweat is Salty- Genetic testing for 36 most
common mutations shows detectable G551D in one allele of CFTR - What is patients
clinical phenotype? -Answer= The Second CFTR Gene was not detected by the
testing obtained
, NURS 706 NBME EXAM TEST QUESTIONS WITH
ANSWERS 2022 UPDATE
74 year old - COPD - "I enjoy coming to see you because you remind me of my
daughter. She died 35 years ago". Which is most appropriate response by physician?
-Answer= You must miss your daughter very much. Tell me about her.
