MSN 611- final exam with verified solutions and a grade of A+

acyclovir - ANSantiviral: tx of hsv, varicella, herpes zoster, CMV MOA: interferes w/ viral synthesis of DNA CI: renal/hepatic disease, caution w/ electrolyte imbalance, seizure disorder, breastfeeding, children AE: n/v, anorexia, diarrhea, lethargy, rash, pruritis, increased bleeding time, phlebitis, nephrotoxicity, neuropathy, thrombocytopenia DI: aminoglycosides, amphotericin B, probenecid, interferon, decreases effect of phenytoin monitor: renal function notes: lowers seizure threshold, safe with pregnancy, monitor for AKI amoxicillin/ amoxil - ANSbroad spectrum penicillin: tx of lower resp infection, UTI, otitis media, sinusitis, pharyngitis/strep, CAP MOA: bactericidal AE: n/v/d, urticaria, rash, inc AST/ALT, BUNC/Cr, superinfections, blood dyscrasias, hemolytic anemia, bone marrow depression CI: renal impairment, caution w/ sensitivity to cephalosporins DI: aspirin, probenecid, tetracycline, erythromycin notes: monitor creatinine amoxicillin clavulanate/ augmentin - ANSbeta-lactam inhibitor: CAP, sinusitis, uncomplicated UTI, otitis media, skin and soft tissue infections MOA: broad spectrum beta-lactam bactericidal AE: n/v/d, rash, candidiasis, hepatitis, seizures CI: hepatic/renal impairment, hypersensitivity DI: probenecid, oral anticoagulants, allopurinol, oral contraceptives notes: monitor creatinine, increased LFTs, c diff; addition of clavulanate increases spectrum to MSSA amphotericin B / ambisome - ANSantifungal: tx of invasive fungal infections; candidiasis, tx of persistently febrile neutropenic host MOA: fungicidal and/or fungistatic AE: fever, rigors, h/a, hypotension, dec potassium and mag, tachypnea, n/v, nephrotoxicity, anaphylaxis CI: anaphylaxis, renal impairment, electrolyte abnormalities, nephrotoxic drugs, steroid use d/t hypokalemia risk, simultaneous granulocyte infusion DI: steroids, granulocytes, nephrotoxic meds notes: monitor electrolytes, infusion-related toxicity, renal toxicity azithromycin / zithromax - ANSmacrolide antibiotic: otitis media, exacerbation of COPD, strep pharyngitis, CAP, chlamydia, MAC infection MOA: bacteriostatic agent AE: QT prolongation, hepatotoxicity, n/d, dizziness, SJS, c diff CI: hypersensitivity, first gen antipsychotic pimozide, QT prolonging meds, hepatic impairment, cardiac issues DI: pimozide, colchicine notes: d/c if signs of hepatotoxicity