The first heart transplant was done in 1967 in South Africa, and
the first one we did was in 1985 in our brand new job. We have
done about 660 heart transplants so far, and this number is up to
2016. There are two kinds of therapy when it comes to treating
Amos depression: induction therapy, which is usually given early
on a transplant, and maintenance therapy, which the patient will
go home on and take for a few days after surgery. Some of the
benefits of induction therapy are because it lasts for weeks, so
then you can start the calcineurin inhibitor later. There are also
benefits to prevention of rejection, but there are also potential
harms, such as increased risk of infections.
Cyclosporine is a drug that can be infused over a period of 12
hours, but it is usually administered over a six-hour period. It is
very expensive, so the nurse usually varies the dosage depending
on the patient's needs. Cyclosporine has a long half-life, meaning
it remains in the body for a long time. There are many drug
interactions with cyclosporine, and it is more likely to cause side
effects when it is used in combination with other drugs. Patients
may also experience gingival hyperplasia and neurotoxicity.
The next agent I am going to talk about is T cell proliferation.
Basically, this agent stops the cycle here. A pure analog than can
be incorporated into the DNA and disrupt the synthesis. An acyl
diagram is rarely used. If the patient cannot tolerate the mmf
witches, I will go over next. Usually, I will go into this agent and iv
Tpo (triptorelin) is one to two as well. There are multiple different
kinds of corticosteroid medications, methylprednisolone being
one of them. We use postop and then after for a few doses, and
then we'll compare them to a prednisone for maintenance
therapy. We generally try not to get been sufficient with
methylprednisolone being the most impressionable. You see right
there just coupes that be a yes. We don't do the auc (adjusted
Urine Concentration). With addition of sirolimus on to the
technical of us, you can potentially bring down the level of
tacrolimus and cost less. Additionally, it is thought that can be
prep an or help with the corner autograph so the other level may
also be improved. Somebody is coming in with cyclosporin, Mr.
Owens there. There is a major drug interaction with this
medication.