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How does the immune system recognize and respond to foreign pathogens to protect the body from infection?

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Lecture notes of 3 pages for the course BI2024 at College Of Medicine And Jnm Hospital (.)

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How does the immune system recognize and respond to foreign pathogens to protect the
body from infection?"

Ans.
The immune system is an incredibly complex and intricate network of cells, tissues, and
organs that work together to protect the body from infection and disease. Its primary function
is to identify and eliminate foreign pathogens, such as bacteria, viruses, and other
microorganisms, that can cause harm to the body. This process involves several steps,
including recognition, activation, and elimination, and is critical to maintaining overall health
and wellbeing.

Recognition

The first step in the immune response to a foreign pathogen is recognition. The immune
system is able to distinguish between self and non-self cells, meaning it can identify cells
that are part of the body and those that are not. This recognition process is carried out by
various cells of the immune system, including macrophages, dendritic cells, and B and T
lymphocytes.

Macrophages and dendritic cells are specialized cells that are able to detect and engulf
foreign pathogens. When a foreign pathogen enters the body, these cells will recognize its
unique molecular patterns, known as antigens, and initiate an immune response. They will
then present these antigens to other cells of the immune system, such as B and T
lymphocytes, in order to activate an immune response.

B and T lymphocytes are white blood cells that are responsible for mounting an immune
response against foreign pathogens. They are able to recognize and respond to specific
antigens, and can differentiate between self and non-self cells. B lymphocytes produce
antibodies, which are proteins that bind to and neutralize foreign pathogens, while T
lymphocytes directly attack and destroy infected cells.

Activation

Once a foreign pathogen has been recognized, the immune system will begin to activate an
immune response. This process involves the activation and proliferation of B and T
lymphocytes, as well as the production of cytokines, which are signaling molecules that help
to coordinate the immune response.

B lymphocytes are activated when they encounter a specific antigen that matches their
antigen receptor. Once activated, they will begin to divide and differentiate into plasma cells,
which are specialized cells that produce antibodies. These antibodies will then bind to the
antigens on the surface of the pathogen, marking it for destruction by other cells of the
immune system.

T lymphocytes are activated when they encounter a foreign pathogen that has been
presented to them by macrophages or dendritic cells. Once activated, they will divide and
differentiate into various types of T cells, including cytotoxic T cells, helper T cells, and
regulatory T cells. Cytotoxic T cells are able to directly attack and destroy infected cells,

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