IMMUNOLOGY
,B cell activation and differentiation
, T cell types | Helper T cells and cytotoxic T cells
The development of the immune system relies heavily on the role of T cells. This is made
possible through the interaction between T cells and antigen-presenting cells.In a talk by Samos
Baldacci, different types of T cells and their associated functions will be discussed. One
important type is the killer T cell, which targets infected or abnormal cells in the body.When a
pathogen infects a cell, the killer T cell identifies it and starts secreting chemical factors such as
perfins and granzymes. These chemicals create pores in the infected cell's membrane, leading
to its death.T helper 1 and T helper 2 are involved in the activation and proliferation of B cells,
while cytotoxic T cells can directly interact with infected cells and cause them to go through
programmed cell death.
Helper T cells Cytotoxic T cells
Helper T cells (Th cells) have a different Cytotoxic T cells (Tc cells) have a
co-receptor called CD4 on their cell surface co-receptor called CD8 on their cell
surface.
CD4 also partners with the T cell receptor but CD8 partners with the T cell receptor and
interacts with MHC class II molecules with MHC class I molecules, acting as a
instead of MHC class I molecules. sort of bridge.
When helper T cells recognize a peptide on When the cytotoxic T cell recognizes the
an antigen presenting cell, they become infected cell, it becomes activated and
activated and begin to produce molecules produces molecules that kill the infected
called cytokines that signal to other immune cell, destroying the pathogen in the
cells. process.
,B cell activation and differentiation
, T cell types | Helper T cells and cytotoxic T cells
The development of the immune system relies heavily on the role of T cells. This is made
possible through the interaction between T cells and antigen-presenting cells.In a talk by Samos
Baldacci, different types of T cells and their associated functions will be discussed. One
important type is the killer T cell, which targets infected or abnormal cells in the body.When a
pathogen infects a cell, the killer T cell identifies it and starts secreting chemical factors such as
perfins and granzymes. These chemicals create pores in the infected cell's membrane, leading
to its death.T helper 1 and T helper 2 are involved in the activation and proliferation of B cells,
while cytotoxic T cells can directly interact with infected cells and cause them to go through
programmed cell death.
Helper T cells Cytotoxic T cells
Helper T cells (Th cells) have a different Cytotoxic T cells (Tc cells) have a
co-receptor called CD4 on their cell surface co-receptor called CD8 on their cell
surface.
CD4 also partners with the T cell receptor but CD8 partners with the T cell receptor and
interacts with MHC class II molecules with MHC class I molecules, acting as a
instead of MHC class I molecules. sort of bridge.
When helper T cells recognize a peptide on When the cytotoxic T cell recognizes the
an antigen presenting cell, they become infected cell, it becomes activated and
activated and begin to produce molecules produces molecules that kill the infected
called cytokines that signal to other immune cell, destroying the pathogen in the
cells. process.
