Pharm HESI - Med Surg II, Over 400 QA

Pharm HESI - Med Surg II, Over 400 QA This Anti-Parkinson's medication should be: • Taken orally • Not to be taken with B6 or tricyclic antidepressants • Take 30 min. before eating proteins Levodopa-Carbidopa (Sinemet) Anti-Parkinson's How does the Levidopa and Carbidopa compliment each other in the combined drug, Sinemet? • Levodopa is a precursor for dopamine and must be given in high doses because it is broken down outside the CNS • Carbidopa prevents the breakdown of Levodopa in the peripheral What is a dopamine replacement drug that is used in the later stages of Parkinson's? Levodopa-Carbidopa [Sinemet] How many times can Levodopa-Carbidopa [Sinemet] be halved? once (it is scored) After how many years (range) does the medication Levodopa-Carbidopa [Sinemet] become ineffective for Parkinson's? after 5 to 10 years What anti-Parkinson's drug is not to be used with narrow angle glaucoma or any undiagnosed sign problem because it activates malignant melanoma? Levodopa-Carbidopa [Sinemet] Name that anti-Parkinson's drug: • Only dopamine modulator • Was first an anti viral • Causes release of dopamine from storage in presynaptic fibers • Blocks reuptake of dopamine • Given in early stages of Parkinson's • Relieves dyskinesia symptoms Amantadine (Symmetrel) How long is Amantadine (Symmetrel) usually effective? 6 to 12 months What are some adverse effects of Amantadine (Symmetrel)? dizziness, insomnia, and nausea What anti-Parkinson's drug helps control the tremors, including muscle rigidity, because of both its dopaminergic and anticholinergic effect? Amantadine (Symmetrel) What is a COMT inhibitor? a drug that inhibits the action of catechol-O-methyl transferase. This enzyme is involved in degrading neurotransmitters. They are used in the treatment of Parkinson's disease. The following are advantages of what classification of drugs (Anti-Parkinson's)? • Blocks breakdown of catecholamines • 2 COMT inhibitors ( tolcopone and entapone) • Entapone prolongs the effects of levodopa