PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
L IM ITED S C L ERODERM A
CRES T S yndr ome Ra yna ud’s Phenomenon FIRS T
Anti-centr omer e THEN
Affects FA C E a nd DIS TA L L IM BS S LLLOOOOWWWW pr og r es s ion to CRES T
Ca lcinos is , Ra yna ud's Phenomenon, Es opha g ea l Dys motility, S cler oda ctyly, Tela ng iecta s ia
LOW s odium, g lucos e, BP
A ddis on’ s Dis e a s e
HIGH pota s s ium, pig menta tion
F - ema le
A - menor r hea (S econda r y)
A ut oim m une He pa t it is
L - FTs Abnor ma l
A - utoimmune Dis ea s e (DM, Thyr oid. Vitilig o)
SL E
Anti -dsD N A and Anti -Smi th
I ni ti al : AN A
Anti -hi stone D ru g - i nd u c e d L u pu s (e . g . H yd ra l a z i ne )
Anti -scl 70 S Y S T E M I C S C L E R OS I S
T ru nk and P ro xi ma l L i mb i nvol vement
Raynaud’s Phenomenon T x: N I F E D I PI N E
Anti -Jo1 P OL Y M Y OS I T I S
I ncreased Creati ne Ki nase
Symmetri cal , di f f used, proxi mal muscl e weaknes D x: M uscl e Bi opsy
S jog r e n’ s S y ndr om e
Anti-Ro a nd Anti-La
Anti-Ro (70%)
Anti-La (30%)
, PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
ALP i ncreased P ri M M M M M a ry B i l i a ry C i rrh o s i s
Sj ogren’s syndrome associ ati on
F emal e Anti -M i tochondri al Anti bodi es
Pruri tus I gM
Jaundi ce M i ddl e-aged F emal e
Anti body: T x: Ursodeoxychol i c Aci d
T x: (2) Chol estyrami ne
C - hur g S t r a us s ( EOS INOPHIL IC Gr a nulom a t os is )
p-ANCA U - lc e r a t iv e C olit is
P - r im a r y S C L EROS ING C hola ng it is
c-AN CA W e g e ne r’ s G ra nu l o ma t o s i s (w i t h P o l ya ng i t i s )
Anti -ti ssue T ransgl utami nase
Anti -Gl i adi n C E L I AC D I S E AS E
Anti -endomysi al
Arthral gi a
N on-erosi ve arthri ti s
Raynaud’s phenomenon SL E
Peri cardi ti s
Protei nuri a I ni ti al : AN A
D i f f use prol i f erati ve gl omerul onephri ti s Conf i rmatory: Anti -dsD N A
Large, mul ti pl e, mouth ul cers
Rel apsi ng and remi tti ng
Rai sed
S leep pr oblems E SR
(Hyper s omnia , Ins omnia )
Ar thr a lg iaN/Mya
ormocyti
lg ia c N ormochromi c Anemi a
LOW C3 and C4
Hea da ches C HRONIC FA TIGUE S YNDROM E
Pa inful lymph nodes WITHOUT enla r g ement
Difficulty thinking , ina bility to concentr a te, difficulties with wor d finding Tr ea tment? CBT a nd GRADED EXERCIS E THERAPY
Flu-like s ymptoms
Beg a n a fter a vir a l infection
All la bor a tor y wor kups NORMAL
Symmetri c Proxi mal M uscl e Weakness
P OL Y M Y AL G I A R H E U M AT I C A
T emporal arteri ti s
Creati ne Ki nase i s N ORM AL
I ni ti al D x: E SR
E SR >30
T x: PRE D N I SOLON E
CRP > 6
Keratoconj uncti vi ti s Si cca (I tchy eyes, sandy sensati on)
Low tear producti on
Rose Bengal Stai n: (+) Corneal ul cerati ons S j o g re n’ s S ynd ro me
D ysphagi a d/t dry mouth
Bi l ateral paroti d swel l i ng f rom Recurrent Paroti ti s
, PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
S ymmetr ica l pr oxima l mus cle wea knes s
Blur r y vis ion
Ja w Cla udica tion TEM PORA L A RTERITIS ( Gia nt C e ll A r t e r it is )
S ca lp Tender nes s Initia l Dx: ES R
Cr ea tine kina s e: NORMAL Confir ma tor y Dx: Tempor a l Ar ter y Biops y
ES R >30
CRP > 6
S yno vi a l F l u i d As pi ra t i o n
D i agnosti c T est f or GOUT
T x: 1) N SAI D s, 2) Col chi ci ne
Al l opuri nol gi ven 2 WE E KS AF T E R acute attack
S E P T I C AR T H R I T I S
M onoarthri ti s, l i mi ted ROM , hot to touch M ost common j oi nt: KN E E then SH OULD E RS
F ever
Wi th D M , H I V, RA, or on steroi ds M ost common bacteri a: S. aureus, N . Gonorrhea i f sexual l y acti ve
D x: Synovi al F l ui d Aspi rati on f or C&S, Bl ood Cul ture
T x: F LUCLOXACI LLI N x 4-6 weeks
R E AC T I VE AR T H R I T I S
Keratoderma bl enorrhagi ca
Urethri ti s
Rei ter’s T ri ad! !
Conj uncti vi ti s, Uvei ti s
M i gratory Ol i goarthri ti s of Knees and Ankl es
T x: N SAI D s, Sul f asal az i ne, M ethotrexate
E rythema N odosum
Ci rni cate bal ani ti s
Rarel y l asts more than 12 months
p-AN CA (+)
E osi nophi l i a C H U R G S T R AU S S
I N CRE ASE D E SR, CRP, I gE OR
E OS I N OP H I L I C G R AN U L OM AT OS I S W I T H P OL Y AN G I I T I S
CT Scan: Ground-gl ass attenuati on
Asthma
Al l ergi c Rhi ni ti s
N asal Pol yps C H U R G S T R AU S S
E osi nophi l i a
Ski n N odul es
Si nusi ti s
N asal Septum Perf orati on
W E G E N E R ’ S G R AN U L OM AT OS I S
E pi staxi s
N asal Crusti ng
Bl eedi ng: N ose, l ungs, ki dneys
H ematuri a
H emoptysi s
Y oung man
AN K Y L OS I N G S P ON D Y L I T I S
Uvei ti s
Aorti c Regurgi tati on
D x: Sacro-i l i ac Joi nt X-Ray
Low back pai n
M orni ng sti f f ness
T x: N SAI D s, Anti -T N F T herapy
Sacro-i l i ac Joi nt T E N D E RN E SS
, PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
H ypercal cemi a
F ever
S AR C OI D OS I S
E rythema N odosum
Lof gren’s Syndrome - Acute F orm!
Pol yarthral gi a
Bi l ateral hi l ar l ymphadenopathy
Persi stent Sore T hroat T ON S I L L AR C AR C I N OM A
Progressi ve H oarseness
Odynophagi a Spreads to?
Anterol ateral neck l ump M AN D I BLE
Pai nl ess upper neck LN swel l i ng
Oti ti s M edi a N AS OP H AR Y N G E AL C AR C I N OM A
Recurrent E pi staxi s Common RF s?
Conducti ve H eari ng Loss E BV, Smoki ng, Al cohol
T i nni tus
Otal gi a
D ri ppi ng of Sal i va
QU I N S Y / P E R I T ON S I L L AR AB S C E S S
Uvul ar D evi ati on
H ot Potato Voi ce
P L U M M E R VI N S ON S Y N D R OM E
Gl ossi ti s D ysphagi a i s due to E sophageal Webs
D ysphagi a
I ron D ef i ci ency Anemi a Ri sk F actor f or Oropharyngeal CA
Postmenopausal Woman
Common i n post-menopausal women
T x: I ron suppl ementati on and Bal l oon D i l ati on
E pi phora
N asal Obstructi on
Bl oody N asal D i scharge
P AR AN AS AL S I N U S T U M OR
H x of Chroni c Si nusi ti s
D i pl opi a
Cheek and Upper T eeth tenderness and swel l i ng
Submandi bul ar swel l i ng and tenderness, promi nent upon chewi ng
Sour taste i n mouth
D ry mouth
C H R ON I C S I AL AD E N I T I S
D ecreased j aw mobi l i ty
F ever
Ri gors
Symmetri cal sal i vary gl and enl argement
Parchment-l i ke mouth dryness M I K U L I C Z S Y N D R OM E
N arrowi ng of pal pebral f i ssures
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
L IM ITED S C L ERODERM A
CRES T S yndr ome Ra yna ud’s Phenomenon FIRS T
Anti-centr omer e THEN
Affects FA C E a nd DIS TA L L IM BS S LLLOOOOWWWW pr og r es s ion to CRES T
Ca lcinos is , Ra yna ud's Phenomenon, Es opha g ea l Dys motility, S cler oda ctyly, Tela ng iecta s ia
LOW s odium, g lucos e, BP
A ddis on’ s Dis e a s e
HIGH pota s s ium, pig menta tion
F - ema le
A - menor r hea (S econda r y)
A ut oim m une He pa t it is
L - FTs Abnor ma l
A - utoimmune Dis ea s e (DM, Thyr oid. Vitilig o)
SL E
Anti -dsD N A and Anti -Smi th
I ni ti al : AN A
Anti -hi stone D ru g - i nd u c e d L u pu s (e . g . H yd ra l a z i ne )
Anti -scl 70 S Y S T E M I C S C L E R OS I S
T ru nk and P ro xi ma l L i mb i nvol vement
Raynaud’s Phenomenon T x: N I F E D I PI N E
Anti -Jo1 P OL Y M Y OS I T I S
I ncreased Creati ne Ki nase
Symmetri cal , di f f used, proxi mal muscl e weaknes D x: M uscl e Bi opsy
S jog r e n’ s S y ndr om e
Anti-Ro a nd Anti-La
Anti-Ro (70%)
Anti-La (30%)
, PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
ALP i ncreased P ri M M M M M a ry B i l i a ry C i rrh o s i s
Sj ogren’s syndrome associ ati on
F emal e Anti -M i tochondri al Anti bodi es
Pruri tus I gM
Jaundi ce M i ddl e-aged F emal e
Anti body: T x: Ursodeoxychol i c Aci d
T x: (2) Chol estyrami ne
C - hur g S t r a us s ( EOS INOPHIL IC Gr a nulom a t os is )
p-ANCA U - lc e r a t iv e C olit is
P - r im a r y S C L EROS ING C hola ng it is
c-AN CA W e g e ne r’ s G ra nu l o ma t o s i s (w i t h P o l ya ng i t i s )
Anti -ti ssue T ransgl utami nase
Anti -Gl i adi n C E L I AC D I S E AS E
Anti -endomysi al
Arthral gi a
N on-erosi ve arthri ti s
Raynaud’s phenomenon SL E
Peri cardi ti s
Protei nuri a I ni ti al : AN A
D i f f use prol i f erati ve gl omerul onephri ti s Conf i rmatory: Anti -dsD N A
Large, mul ti pl e, mouth ul cers
Rel apsi ng and remi tti ng
Rai sed
S leep pr oblems E SR
(Hyper s omnia , Ins omnia )
Ar thr a lg iaN/Mya
ormocyti
lg ia c N ormochromi c Anemi a
LOW C3 and C4
Hea da ches C HRONIC FA TIGUE S YNDROM E
Pa inful lymph nodes WITHOUT enla r g ement
Difficulty thinking , ina bility to concentr a te, difficulties with wor d finding Tr ea tment? CBT a nd GRADED EXERCIS E THERAPY
Flu-like s ymptoms
Beg a n a fter a vir a l infection
All la bor a tor y wor kups NORMAL
Symmetri c Proxi mal M uscl e Weakness
P OL Y M Y AL G I A R H E U M AT I C A
T emporal arteri ti s
Creati ne Ki nase i s N ORM AL
I ni ti al D x: E SR
E SR >30
T x: PRE D N I SOLON E
CRP > 6
Keratoconj uncti vi ti s Si cca (I tchy eyes, sandy sensati on)
Low tear producti on
Rose Bengal Stai n: (+) Corneal ul cerati ons S j o g re n’ s S ynd ro me
D ysphagi a d/t dry mouth
Bi l ateral paroti d swel l i ng f rom Recurrent Paroti ti s
, PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
S ymmetr ica l pr oxima l mus cle wea knes s
Blur r y vis ion
Ja w Cla udica tion TEM PORA L A RTERITIS ( Gia nt C e ll A r t e r it is )
S ca lp Tender nes s Initia l Dx: ES R
Cr ea tine kina s e: NORMAL Confir ma tor y Dx: Tempor a l Ar ter y Biops y
ES R >30
CRP > 6
S yno vi a l F l u i d As pi ra t i o n
D i agnosti c T est f or GOUT
T x: 1) N SAI D s, 2) Col chi ci ne
Al l opuri nol gi ven 2 WE E KS AF T E R acute attack
S E P T I C AR T H R I T I S
M onoarthri ti s, l i mi ted ROM , hot to touch M ost common j oi nt: KN E E then SH OULD E RS
F ever
Wi th D M , H I V, RA, or on steroi ds M ost common bacteri a: S. aureus, N . Gonorrhea i f sexual l y acti ve
D x: Synovi al F l ui d Aspi rati on f or C&S, Bl ood Cul ture
T x: F LUCLOXACI LLI N x 4-6 weeks
R E AC T I VE AR T H R I T I S
Keratoderma bl enorrhagi ca
Urethri ti s
Rei ter’s T ri ad! !
Conj uncti vi ti s, Uvei ti s
M i gratory Ol i goarthri ti s of Knees and Ankl es
T x: N SAI D s, Sul f asal az i ne, M ethotrexate
E rythema N odosum
Ci rni cate bal ani ti s
Rarel y l asts more than 12 months
p-AN CA (+)
E osi nophi l i a C H U R G S T R AU S S
I N CRE ASE D E SR, CRP, I gE OR
E OS I N OP H I L I C G R AN U L OM AT OS I S W I T H P OL Y AN G I I T I S
CT Scan: Ground-gl ass attenuati on
Asthma
Al l ergi c Rhi ni ti s
N asal Pol yps C H U R G S T R AU S S
E osi nophi l i a
Ski n N odul es
Si nusi ti s
N asal Septum Perf orati on
W E G E N E R ’ S G R AN U L OM AT OS I S
E pi staxi s
N asal Crusti ng
Bl eedi ng: N ose, l ungs, ki dneys
H ematuri a
H emoptysi s
Y oung man
AN K Y L OS I N G S P ON D Y L I T I S
Uvei ti s
Aorti c Regurgi tati on
D x: Sacro-i l i ac Joi nt X-Ray
Low back pai n
M orni ng sti f f ness
T x: N SAI D s, Anti -T N F T herapy
Sacro-i l i ac Joi nt T E N D E RN E SS
, PLAB 1 by DT N
Study this set o nline at: https://www.cram.co m/flashcards/plab-1-1330 258 6
H ypercal cemi a
F ever
S AR C OI D OS I S
E rythema N odosum
Lof gren’s Syndrome - Acute F orm!
Pol yarthral gi a
Bi l ateral hi l ar l ymphadenopathy
Persi stent Sore T hroat T ON S I L L AR C AR C I N OM A
Progressi ve H oarseness
Odynophagi a Spreads to?
Anterol ateral neck l ump M AN D I BLE
Pai nl ess upper neck LN swel l i ng
Oti ti s M edi a N AS OP H AR Y N G E AL C AR C I N OM A
Recurrent E pi staxi s Common RF s?
Conducti ve H eari ng Loss E BV, Smoki ng, Al cohol
T i nni tus
Otal gi a
D ri ppi ng of Sal i va
QU I N S Y / P E R I T ON S I L L AR AB S C E S S
Uvul ar D evi ati on
H ot Potato Voi ce
P L U M M E R VI N S ON S Y N D R OM E
Gl ossi ti s D ysphagi a i s due to E sophageal Webs
D ysphagi a
I ron D ef i ci ency Anemi a Ri sk F actor f or Oropharyngeal CA
Postmenopausal Woman
Common i n post-menopausal women
T x: I ron suppl ementati on and Bal l oon D i l ati on
E pi phora
N asal Obstructi on
Bl oody N asal D i scharge
P AR AN AS AL S I N U S T U M OR
H x of Chroni c Si nusi ti s
D i pl opi a
Cheek and Upper T eeth tenderness and swel l i ng
Submandi bul ar swel l i ng and tenderness, promi nent upon chewi ng
Sour taste i n mouth
D ry mouth
C H R ON I C S I AL AD E N I T I S
D ecreased j aw mobi l i ty
F ever
Ri gors
Symmetri cal sal i vary gl and enl argement
Parchment-l i ke mouth dryness M I K U L I C Z S Y N D R OM E
N arrowi ng of pal pebral f i ssures
