Coagulation Final Review 2023 with complete solution
Tissue factor
Which of the following initiates in vivo coagulation by activation of factor VII?
Plasmin activator
Thrombomodulin
Protein C
Tissue factor
Sodium citrate
The anticoagulant of choice for most routine coagulation studies is:
Ethylenediaminetetraacetic acid (EDTA)
Sodium citrate
Heparin
Sodium oxalate
1:9
Which ratio of anticoagulant-to-blood is correct for coagulation procedures?
1:5
1:10
1:4
1:9
PT and APTT
Which test would be abnormal in a patient with factor X deficiency?
PT and APTT
PT only
APTT only
Thrombin time
Factor XIII
Which clotting factor is not measured by PT and APTT tests?
Factor XIII
,Factor VIII
Factor V
Factor IX
It is required for carboxylation of glutamate residues of some coagulation factors
Which of the following characterizes vitamin K?
Its activity is enhanced by heparin therapy
It is required for carboxylation of glutamate residues of some coagulation factors
It is required for biological activity of fibrinolysis
It is made by the endothelial cells
XII, XI, IX, VIII, X, V, II, I
Which of the following clotting factors are measured by the APTT test?
XII, VII, X, V, II, I
II, VII, IX, X
XII, XI, IX, VIII, X, V, II, I
VII, X, V, II, I
PT and APTT
Which coagulation test(s) would be abnormal in a vitamin K-deficient patient?
PT and APTT
Fibrinogen level
Thrombin time
PT only
It standardizes PT results
Which of the following is correct regarding the international normalized ratio (INR)?
It standardizes PT results
It is used to monitor heparin therapy
It standardizes APTT results
It uses the International Sensitivity Ratio (ISR)
,Reject the sample and request a new sample
A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the
laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the
following morning for a tonsillectomy. Which of the following is the necessary course of
action by the technologist?
Report the PT result
Report the APTT result
Run both tests in duplicate and report the average result
Reject the sample and request a new sample
Increased platelet aggregation and clotting
Thrombotic thrombocytopenic purpura (TTP) is characterized by:
Increased platelet aggregation and clotting
Thrombocytosis
Prolonged PT
Prolonged APTT
Hypersplenism
Thrombocytopenia may be associated with:
Hypersplenism
Increased proliferation of pluripotential stem cells
Acute blood loss
Postsplenectomy
Cyclo-oxygenase
Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?
Thromboxane A2 synthetase
Cyclo-oxygenase
Prostacyclin sythetase
Phospholipase
Glycoprotein Ib
Normal platelet adhesion depends upon:
, Glycoprotein Ib
Fibrinogen
Calcium
Glycoprotein IIb, IIIa complex
Platelet count
Which of the following test results is normal in a patient with classic von Willebrand's
disease?
Activated partial thromboplastin time
Platelet count
Factor VIII:C and von Willebrand's factor (VWF) levels
Bleeding time
Thrombocytopenia and giant platelets
Bernard-Soulier syndrome is associated with:
Thrombocytopenia and giant platelets
Decreased factor VIII assay
Decreased bleeding time
Abnormal platelet aggregation to ADP
Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and
epinephrine
Which set of platelet responses would be most likely associated with Glanzmann's
thrombasthenia?
Normal platelet aggregation to ADP and ristocetin; decreased aggregation to collagen
Normal platelet aggregation to collagen; decreased aggregation to ADP and ristocetin
Normal platelet aggregation to ADP; decreased aggregation to collagen and ristocetin
Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and
epinephrine
Spontaneous remission within a few weeks
Which of the following is a characteristic of acute immune thrombocytopenic purpura?
Insidious onset
Tissue factor
Which of the following initiates in vivo coagulation by activation of factor VII?
Plasmin activator
Thrombomodulin
Protein C
Tissue factor
Sodium citrate
The anticoagulant of choice for most routine coagulation studies is:
Ethylenediaminetetraacetic acid (EDTA)
Sodium citrate
Heparin
Sodium oxalate
1:9
Which ratio of anticoagulant-to-blood is correct for coagulation procedures?
1:5
1:10
1:4
1:9
PT and APTT
Which test would be abnormal in a patient with factor X deficiency?
PT and APTT
PT only
APTT only
Thrombin time
Factor XIII
Which clotting factor is not measured by PT and APTT tests?
Factor XIII
,Factor VIII
Factor V
Factor IX
It is required for carboxylation of glutamate residues of some coagulation factors
Which of the following characterizes vitamin K?
Its activity is enhanced by heparin therapy
It is required for carboxylation of glutamate residues of some coagulation factors
It is required for biological activity of fibrinolysis
It is made by the endothelial cells
XII, XI, IX, VIII, X, V, II, I
Which of the following clotting factors are measured by the APTT test?
XII, VII, X, V, II, I
II, VII, IX, X
XII, XI, IX, VIII, X, V, II, I
VII, X, V, II, I
PT and APTT
Which coagulation test(s) would be abnormal in a vitamin K-deficient patient?
PT and APTT
Fibrinogen level
Thrombin time
PT only
It standardizes PT results
Which of the following is correct regarding the international normalized ratio (INR)?
It standardizes PT results
It is used to monitor heparin therapy
It standardizes APTT results
It uses the International Sensitivity Ratio (ISR)
,Reject the sample and request a new sample
A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the
laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the
following morning for a tonsillectomy. Which of the following is the necessary course of
action by the technologist?
Report the PT result
Report the APTT result
Run both tests in duplicate and report the average result
Reject the sample and request a new sample
Increased platelet aggregation and clotting
Thrombotic thrombocytopenic purpura (TTP) is characterized by:
Increased platelet aggregation and clotting
Thrombocytosis
Prolonged PT
Prolonged APTT
Hypersplenism
Thrombocytopenia may be associated with:
Hypersplenism
Increased proliferation of pluripotential stem cells
Acute blood loss
Postsplenectomy
Cyclo-oxygenase
Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?
Thromboxane A2 synthetase
Cyclo-oxygenase
Prostacyclin sythetase
Phospholipase
Glycoprotein Ib
Normal platelet adhesion depends upon:
, Glycoprotein Ib
Fibrinogen
Calcium
Glycoprotein IIb, IIIa complex
Platelet count
Which of the following test results is normal in a patient with classic von Willebrand's
disease?
Activated partial thromboplastin time
Platelet count
Factor VIII:C and von Willebrand's factor (VWF) levels
Bleeding time
Thrombocytopenia and giant platelets
Bernard-Soulier syndrome is associated with:
Thrombocytopenia and giant platelets
Decreased factor VIII assay
Decreased bleeding time
Abnormal platelet aggregation to ADP
Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and
epinephrine
Which set of platelet responses would be most likely associated with Glanzmann's
thrombasthenia?
Normal platelet aggregation to ADP and ristocetin; decreased aggregation to collagen
Normal platelet aggregation to collagen; decreased aggregation to ADP and ristocetin
Normal platelet aggregation to ADP; decreased aggregation to collagen and ristocetin
Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and
epinephrine
Spontaneous remission within a few weeks
Which of the following is a characteristic of acute immune thrombocytopenic purpura?
Insidious onset
