Psychopharmacology
& Psychopathology
SOW-PSB3BC16E
Part 1: Principles of psychopharmacology
Pharmacokinetics &
Pharmacogenetics
Hanneke den Ouden
, Questions from Monday
§ Can agonists be irreversible?
§ Yes!
§ Oxymorphazone: Analgesic, potent and long acting μ-opioid agonist which binds irreversibly
§ … in practice, the distinction may be more a matter of degree, in which the binding affinity of an
irreversible agonist is some orders of magnitude greater than that of an agonist (oxymorphazone
48hrs)
§ Are neurotransmitters promiscuous at receptors?
§ Yes!
§ E.g. noradrenaline can bind to D2,D3,D4 receptors
2
, DRUG
The importance of pharmacokinetics
EFFECT
4
, 71 get drug into your system
2) drug gets ready for absorption ( lg pill
. breaks down)
3) pharmacokinetic phase
DRUG
Disintegration of the
applied compound
Dissolving of the I Pharmaceutical phase
drug
Drug available for absorption
Absorption
Distribution
Metabolism
Elimination
} important 4
steps !
II Pharmacokinetics
Drug available for action
Drug-receptor
interaction III Pharmacodynamics
EFFECT
5
& Psychopathology
SOW-PSB3BC16E
Part 1: Principles of psychopharmacology
Pharmacokinetics &
Pharmacogenetics
Hanneke den Ouden
, Questions from Monday
§ Can agonists be irreversible?
§ Yes!
§ Oxymorphazone: Analgesic, potent and long acting μ-opioid agonist which binds irreversibly
§ … in practice, the distinction may be more a matter of degree, in which the binding affinity of an
irreversible agonist is some orders of magnitude greater than that of an agonist (oxymorphazone
48hrs)
§ Are neurotransmitters promiscuous at receptors?
§ Yes!
§ E.g. noradrenaline can bind to D2,D3,D4 receptors
2
, DRUG
The importance of pharmacokinetics
EFFECT
4
, 71 get drug into your system
2) drug gets ready for absorption ( lg pill
. breaks down)
3) pharmacokinetic phase
DRUG
Disintegration of the
applied compound
Dissolving of the I Pharmaceutical phase
drug
Drug available for absorption
Absorption
Distribution
Metabolism
Elimination
} important 4
steps !
II Pharmacokinetics
Drug available for action
Drug-receptor
interaction III Pharmacodynamics
EFFECT
5
