Cellular and Molecular Immunology 9th Edition Abbas Test Bank

Harvard-MIT Division of Health Sciences and Technology
HST.176: Cellular and Molecular Immunology
Course Director: Dr. Shiv Pillai




T CELL MEDIATED IMMUNITY
(CMI)

NK CELLS




Role of Cell-Mediated Immunity

• Adaptive immune responses to intracellular
microbes that are inaccessible to antibodies.
– Microbes that are internalized and confined to
phagosomes
– Viruses in the cytoplasm
• Pathologic responses
– Autoimmunity
– Graft rejection)




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, Experimental protocol for determining role of T cells and antibodies
in immunity to an infection




See Immunobiology, by Janeway,C., Travers,P., Walport,M. and Capra, J., Garland Publishing, 5th edition, 2001 &
Cellular amd Molecular Immunolgy by Abbas,A., Pober,J., and Lichtman, A., W B Saunders; 4th edition, 2000.




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, Cell mediated immunity to Listeria monocytogenes




See Immunobiology, by Janeway,C., Travers,P., Walport,M. and Capra, J., Garland Publishing, 5th edition, 2001 &
Cellular amd Molecular Immunolgy by Abbas,A., Pober,J., and Lichtman, A., W B Saunders; 4th edition, 2000.




Properties of Cell-Mediated Immunity

• T cells recognize and respond to foreign protein
antigens only when a peptide fragment of the
antigen is presented in a complex with an MHC
molecule on the surface of an APC.




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, Properties of Cell-Mediated Immunity

• T cells recognize and respond to foreign protein
antigens only when a peptide fragment of the
antigen is presented in a complex with an MHC
molecule on the surface of an APC.

• Therefore, cell mediated immunity is directed at
cells that have intracellular antigens which are
processed and presented as peptide-MHC
complexes on their surface.




Types of Cell-Mediated Immune Responses


• CD4+ TH1/delayed type hypersensitivity
(DTH) responses

• Th2 responses

• Cytolytic T lymphocyte responses




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