PHARMACOLOGY - GI DRUGS 2023
Pantoprazole
PPI with the least drug-drug interactions
Proximal small intestine/duodenum
Site of absorption of Proton pump inhibitors
Cimetidine
H2 blocker with CYP450 inhibition
Forms protective coating on ulcerated tissue
MOA of Bismuth subsalicylate
Bulk-forming laxative
MOA of Psyllium
Blocking D2 receptors
Metoclopramide and Domperidone act as prokinetic agents by
Senna (anthraquinone-containing laxatives)
Melanosis coli may occur as a result of taking
Stimulant (directly stimulates enteric nervous system)
Bisacodyl is what type of laxative
Ursodeoxycholic acid
Drug that may be used in the dissolution of small cholesterol gallstones
Vitamin B12 deficiency, pneumonia, small benign gastric fundic-gland polyps
Side effects with long term use of PPIs
Metoclopramide
Increase motility and resting tone of GIT for gastroparesis
Parkinsonian features, Tardive dyskinesia, Galactorrhea, Akathisia
Metoclopramide adverse effects
Hyoscine
Blocks muscarinic receptors for treatment of nausea and vomiting
Bloody, mucoid stools, Young children, Acute ulcerative colitis
Loperamide contraindications
Finasteride
Other drug that may be given to a patient with alopecia already given Minoxidil
· Promotes satiety via hypothalamic receptor · Slows down gastric emptying time
· Inhibits inappropriate secretion of glucagon
Effects of Pramlintide
· Steroids · Surgery · Immunomodulators
Management of Crohn's disease
Terlipressin
Drug effective in bleeding esophageal varices
Calcium channel blockers
Antihypertensive contraindicated in patients with bleeding esophageal varices
Diphenoxylate
Centrally acting acting anti-diarrheal agent
Osteoporosis and bone fracture, Hypomagnesemia, Eradicate H. pylori
Complications of long-term use of Omeprazole
Amylase, Lipase, Proteases
Pantoprazole
PPI with the least drug-drug interactions
Proximal small intestine/duodenum
Site of absorption of Proton pump inhibitors
Cimetidine
H2 blocker with CYP450 inhibition
Forms protective coating on ulcerated tissue
MOA of Bismuth subsalicylate
Bulk-forming laxative
MOA of Psyllium
Blocking D2 receptors
Metoclopramide and Domperidone act as prokinetic agents by
Senna (anthraquinone-containing laxatives)
Melanosis coli may occur as a result of taking
Stimulant (directly stimulates enteric nervous system)
Bisacodyl is what type of laxative
Ursodeoxycholic acid
Drug that may be used in the dissolution of small cholesterol gallstones
Vitamin B12 deficiency, pneumonia, small benign gastric fundic-gland polyps
Side effects with long term use of PPIs
Metoclopramide
Increase motility and resting tone of GIT for gastroparesis
Parkinsonian features, Tardive dyskinesia, Galactorrhea, Akathisia
Metoclopramide adverse effects
Hyoscine
Blocks muscarinic receptors for treatment of nausea and vomiting
Bloody, mucoid stools, Young children, Acute ulcerative colitis
Loperamide contraindications
Finasteride
Other drug that may be given to a patient with alopecia already given Minoxidil
· Promotes satiety via hypothalamic receptor · Slows down gastric emptying time
· Inhibits inappropriate secretion of glucagon
Effects of Pramlintide
· Steroids · Surgery · Immunomodulators
Management of Crohn's disease
Terlipressin
Drug effective in bleeding esophageal varices
Calcium channel blockers
Antihypertensive contraindicated in patients with bleeding esophageal varices
Diphenoxylate
Centrally acting acting anti-diarrheal agent
Osteoporosis and bone fracture, Hypomagnesemia, Eradicate H. pylori
Complications of long-term use of Omeprazole
Amylase, Lipase, Proteases
