NR 507 Week 4 Midterm Study Guides
NR 507: Advanced Pathophysiology
Verified And Correct Answers
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, Midterm Study Guide
Pulmonary:
Review concepts related to anticholinergic drugs and the treatment for
asthma
o (Block acetylcholine binding (primarily in lung) ->
bronchodilation through decreased parasympathetic response
Tiotropium, Ipratropium
o Short-acting beta-adrenergic agonists (SABA) – activate beta
receptors primarily in the lung -> bronchodilation through
increased sympathetic response
Albuterol
o Oral corticosteroids – inhibit inflammatory cells and chemical
production -> reduce inflammatory process
Prednisone, prednisolone, methylprednisolone
o Long acting:
Inhaled corticosteroids
Beclomethasone, triamcinolone
Mast cell stabilizers
Cromolyn
Leukotriene modifiers
Zafirlukast, Montelukast
Long acting beta2 adrenergic agonists
Salmeterol
Methylxanthines
Theophylline
Monoclonal antibodies
Omalizumab
Bronchitis and associated pathogenesis
o In bronchitis, inspired irritants promote bronchial inflammation,
causing bronchial edema, increases the size and number of
mucous glands and goblet cells in the airway epithelium, smooth
muscle hypertrophy with fibrosis, and narrowing of the airways.
o Hypersecretion of thick, tenacious mucus occurs and cannot be
cleared because of impaired ciliary function. The lung’s defense
mechanisms are therefore compromised, increasing
susceptibility to pulmonary infection, which contributes to airway
injury and ineffective repair.
o Frequent infectious exacerbations from bacterial colonization of
damaged airways are complicated by bronchospasm with
dyspnea and productive cough.
Chronic bronchitis and related acid/base disturbances, perfusion, blood
flow between the heart and lungs
NR 507: Advanced Pathophysiology
Verified And Correct Answers
Best document for Exam
Secure Better Grades
, Midterm Study Guide
Pulmonary:
Review concepts related to anticholinergic drugs and the treatment for
asthma
o (Block acetylcholine binding (primarily in lung) ->
bronchodilation through decreased parasympathetic response
Tiotropium, Ipratropium
o Short-acting beta-adrenergic agonists (SABA) – activate beta
receptors primarily in the lung -> bronchodilation through
increased sympathetic response
Albuterol
o Oral corticosteroids – inhibit inflammatory cells and chemical
production -> reduce inflammatory process
Prednisone, prednisolone, methylprednisolone
o Long acting:
Inhaled corticosteroids
Beclomethasone, triamcinolone
Mast cell stabilizers
Cromolyn
Leukotriene modifiers
Zafirlukast, Montelukast
Long acting beta2 adrenergic agonists
Salmeterol
Methylxanthines
Theophylline
Monoclonal antibodies
Omalizumab
Bronchitis and associated pathogenesis
o In bronchitis, inspired irritants promote bronchial inflammation,
causing bronchial edema, increases the size and number of
mucous glands and goblet cells in the airway epithelium, smooth
muscle hypertrophy with fibrosis, and narrowing of the airways.
o Hypersecretion of thick, tenacious mucus occurs and cannot be
cleared because of impaired ciliary function. The lung’s defense
mechanisms are therefore compromised, increasing
susceptibility to pulmonary infection, which contributes to airway
injury and ineffective repair.
o Frequent infectious exacerbations from bacterial colonization of
damaged airways are complicated by bronchospasm with
dyspnea and productive cough.
Chronic bronchitis and related acid/base disturbances, perfusion, blood
flow between the heart and lungs
